Results 21 to 30 of about 580,293 (310)
The endothelial glycocalyx in critical illness: A pediatric perspective
Matrix Biology Plus, 2022 The vascular endothelium is the interface between circulating blood and end organs and thus has a critical role in preserving organ function. The endothelium is lined by a glycan-rich glycocalyx that uniquely contributes to endothelial function through ...
Robert P. Richter +4 more
doaj
Foods, 2018 Effects of proteolytic (Neutrase, Bacillus subtilis-originate, 0.20 (P1) and 0.40 g 100 L−1 (P2)) and lipolytic (Piccantase A, Mucor miehei-originated, 0.05 (L1) and 0.10 g 100 L−1 (L2)) enzyme supplementations to cheese milk on lipolysis and
Oya Berkay Karaca, Mehmet Güven
doaj +1 more source
Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24. [PDF]
, 2016 Off-target binding of hydrophobic drugs can lead to unwanted side effects, either through specific or non-specific binding to unintended membrane protein targets.
Carpenter, Elisabeth P +7 more
core +2 more sources
Journal of Biological Researches, 2012 Protein on stored milks spoiled due to protease activities of Pseudomonas fluorescens. To know protease effect on milks, protease activities of semi-purified P. fluorescens on protein degradation in stored pasteurized milks were detected.
Tatik Khusniati, Irma Normalia
doaj +1 more source
Biomedical and Biotechnology Research Journal, 2022 Background: The contemporary usage of leather products has established large number of tanneries worldwide and increased the production of leather goods, releasing huge solid and liquid tannery waste.
Saranya Nachimuthu +2 more
doaj +1 more source
Convergent dynamics in the protease enzymatic superfamily [PDF]
J. Am. Chem. Soc. 128, 9766-9772 (2006), 2006 Proteases regulate various aspects of the life cycle in all organisms by cleaving specific peptide bonds. Their action is so central for biochemical processes that at least 2% of any known genome encodes for proteolytic enzymes. Here we show that selected proteases pairs, despite differences in oligomeric state, catalytic residues and fold, share a ...
arxiv +1 more source
IUBMB Life, 2009 AbstractOver one third of all known proteolytic enzymes are serine proteases. Among these, the trypsins underwent the most predominant genetic expansion yielding the enzymes responsible for digestion, blood coagulation, fibrinolysis, development, fertilization, apoptosis, and immunity.
openaire +4 more sources
Properdin oligomers adopt rigid extended conformations supporting function
eLife, 2021 Properdin stabilizes convertases formed upon activation of the complement cascade within the immune system. The biological activity of properdin depends on the oligomerization state, but whether properdin oligomers are rigid and how their structure links
Dennis V Pedersen +6 more
doaj +1 more source
Predictability of IL-28B-polymorphism on protease-inhibitor-based triple-therapy in chronic HCV-genotype-1 patients: A meta-analysis [PDF]
World Journal of Hepatology, 6(10):759-765, 2014, 2014 AIM: To investigate the predictability of interleukin-28B single nucleotide polymorphism rs12979860 with respect to sustained virological response (SVR) in chronically hepatitis C virus (HCV) genotype-1 patients treated with a protease-inhibitor and pegylated interferon-$\alpha$ (Peg-INF-$\alpha$) based triple-therapy.
arxiv +1 more source
In vivo imaging of protease activity by Probody therapeutic activation. [PDF]
, 2016 Probody™ therapeutics are recombinant, proteolytically-activated antibody prodrugs, engineered to remain inert until activated locally by tumor-associated proteases.
Craik, Charles S +4 more
core +1 more source