Molecular Therapy: Oncolytics, 2023 Glioblastoma (GBM) is the most common aggressive malignant brain cancer and is chemo- and radioresistant, with poor therapeutic outcomes. The “double-edged sword” of virus-induced cell death could be a potential solution if the oncolytic virus ...
Yu-Ting Kao +5 more
doaj +1 more source
Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors
Nature Communications, 2020 The pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to expand. Papain-like protease (PLpro) is one of two SARS-CoV-2 proteases potentially targetable with antivirals.
J. Osipiuk +20 more
semanticscholar +1 more source
Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease
Nature Communications, 2020 COVID-19 was declared a pandemic on March 11 by WHO, due to its great threat to global public health. The coronavirus main protease (Mpro, also called 3CLpro) is essential for processing and maturation of the viral polyprotein, therefore recognized as an
L. Fu +15 more
semanticscholar +1 more source
ClgR regulation of chaperone and protease systems is essential for Mycobacterium tuberculosis parasitism of the macrophage [PDF]
, 2010 Chaperone and protease systems play essential roles in cellular homeostasis and have vital functions in controlling the abundance of specific cellular proteins involved in processes such as transcription, replication, metabolism and virulence.
Butler, R.E. +7 more
core +6 more sources
Phenotypic hypersusceptibility to multiple protease inhibitors and low replicative capacity in patients who are chronically infected with human immunodeficiency virus type 1 [PDF]
, 2005 Increased susceptibility to the protease inhibitors saquinavir and amprenavir has been observed in human immunodeficiency virus type 1 (HIV-1) with specific mutations in protease (V82T and N88S).
Clotet, B +7 more
core +2 more sources
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease
Nature Communications, 2020 COVID-19, caused by SARS-CoV-2, lacks effective therapeutics. Additionally, no antiviral drugs or vaccines were developed against the closely related coronavirus, SARS-CoV-1 or MERS-CoV, despite previous zoonotic outbreaks.
A. Douangamath +33 more
semanticscholar +1 more source
Structure of protease-cleaved escherichia coliα-2-macroglobulin reveals a putative mechanism of conformational activation for protease entrapment [PDF]
, 2015 Bacterial -2-macroglobulins have been suggested to function in defence as broad-spectrum inhibitors of host proteases that breach the outer membrane.
Burchmore, R.J.S. +9 more
core +2 more sources
Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
Nature Communications, 2020 The main protease, Mpro (or 3CLpro) in SARS-CoV-2 is a viable drug target because of its essential role in the cleavage of the virus polypeptide. Feline infectious peritonitis, a fatal coronavirus infection in cats, was successfully treated previously ...
Wayne Vuong +13 more
semanticscholar +1 more source
Frontiers in Molecular Biosciences, 2021 Rising antibiotic resistance urgently calls for the discovery and evaluation of novel antibiotic classes and unique antibiotic targets. The caseinolytic protease Clp emerged as an unprecedented target for antibiotic therapy 15 years ago when it was ...
Heike Brötz-Oesterhelt +2 more
doaj +1 more source
Viruses, 2022 Alphaviruses are positive-strand RNA viruses, mostly being mosquito-transmitted. Cells infected by an alphavirus become resistant to superinfection due to a block that occurs at the level of RNA replication. Alphavirus replication proteins, called nsP1-4,
Liubov Cherkashchenko +4 more
doaj +1 more source