Results 21 to 30 of about 943,189 (296)
Frontiers in Cellular and Infection Microbiology, 2023 IntroductionPseudomonas aeruginosa causes vision threatening keratitis. The LasR transcription factor regulates virulence factors in response to the quorum sensing molecule N-3-oxo-dodecanoyl-L-homoserine lactone. P.
Robert M. Q. Shanks +16 more
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Cis-Allosteric Regulation of HIV-1 Reverse Transcriptase by Integrase
Viruses, 2022 Reverse transcriptase (RT) and integrase (IN) are encoded tandemly in the pol genes of retroviruses. We reported recently that HIV-1 RT and IN need to be supplied as the pol precursor intermediates, in which RT and IN are in fusion form (RTIN) to exert ...
Takao Masuda +5 more
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Proteases as therapeutics [PDF]
Biochemical Journal, 2011 Proteases are an expanding class of drugs that hold great promise. The U.S. FDA (Food and Drug Administration) has approved 12 protease therapies, and a number of next generation or completely new proteases are in clinical development. Although they are a well-recognized class of targets for inhibitors, proteases themselves have not typically been ...
Michael J. Page +2 more
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Cases inefficient antiretroviral therapy for HIV-1 in children
Журнал инфектологии, 2017 Aim. Study cases virologic failure ART HIV-1 in children.Materials and methods. The blood plasma samples of 6 patients with HIV infection were used, identified under 1 year of life, from the North-West Federal District of the Russian Federation, received
Yu. V. Ostankova +3 more
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Endocan in Acute Leukemia: Current Knowledge and Future Perspectives
Biomolecules, 2022 Endocan is a soluble dermatan sulfate proteoglycan expressed by endothelial cells and detected in serum/plasma. Its expression is increased in tumors/tumor vessels in several human malignancies, and high expression (high serum/plasma levels or tumor ...
Håkon Reikvam +5 more
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Dermatophyte infection: from fungal pathogenicity to host immune responses
Frontiers in Immunology, 2023 Dermatophytosis is a common superficial infection caused by dermatophytes, a group of pathogenic keratinophilic fungi. Apart from invasion against skin barrier, host immune responses to dermatophytes could also lead to pathologic inflammation and tissue ...
Ruixin Deng +11 more
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Proteases, Protease-Activated Receptors, and Atherosclerosis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2018 Coagulation activation by the TF (tissue factor) pathway plays pivotal roles in triggering platelets and precipitating acute coronary syndromes. Although dual antiplatelet therapy is effective in secondary cardiovascular prevention, combining platelet antagonism with low-dose aspirin and the oral coagulation FXa antagonist rivaroxaban has a synergistic
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eLife, 2019 The secretion of peptides and proteins is essential for survival and ecological adaptation of bacteria. Dual-functional ATP-binding cassette transporters export antimicrobial or quorum signaling peptides in Gram-positive bacteria.
Silvia C Bobeica +7 more
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Nature CommunicationsBronchopulmonary dysplasia (BPD) is a chronic lung disease of prematurity. Exposure to noxious stimuli such as hyperoxia, volutrauma, and infection in infancy can have long-reaching impacts on lung health and predispose towards the development of ...
Teodora Nicola +14 more
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Biology, 2020 An increased need by the green industry for enzymes that can be exploited for eco-friendly industrial applications led us to isolate and identify a unique protease obtained from a proteolytic Bacillus megaterium-TK1 strain from a seawater source.
Tamilvendan Manavalan +3 more
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