Results 221 to 230 of about 3,932,956 (396)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Biophysical and Functional Characterization of a Thermally Stable Bifunctional Serine Protease Inhibitor from <i>Cleome viscosa</i> Seeds. [PDF]

Int J Mol Sci
Radhakrishnan M, Senthilvadivelu V, Nadendla EK, Sivashanmugan K, Krishnasamy G.   +4 more
europepmc   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

The diagnostic value of serum cysteine protease inhibitor (CST4) in colorectal cancer: a preliminary study. [PDF]

BMC Gastroenterol
Lan Y, Zhang L, Li R.
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Production of human cathepsins using Expi293™ mammalian cell expression system for off-target activity of cysteine protease inhibitor screening. [PDF]

Protein Sci
Turner Z, Arutyunova E, Bui DT, Han L, Kandadai AS, Bai B, Young HS, Mahal LK, Klassen JS, Lemieux MJ.   +9 more
europepmc   +1 more source

Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032)

Antimicrobial Agents and Chemotherapy, 2012
F. Mcphee, A. Sheaffer, J. Friborg, D. Hernandez, P. Falk, G. Zhai, Steven M. Levine, Susan Chaniewski, Fei Yu, D. Barry, Chaoqun Chen, Min S. Lee, Kathy Mosure, Li-Qiang Sun, M. Sinz, N. Meanwell, R. Colonno, J. Knipe, P. Scola   +18 more
semanticscholar   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Immunoregulation mediated by the enzyme inhibitory activity of helminth-derived serine protease inhibitor affects the protective efficiency of vaccines. [PDF]

Virulence
Shi W, Liu Y, Bai X, Liang Y, Zhang S, Sun L, Lin W, Liu X, Xu N.   +8 more
europepmc   +1 more source

In Silico Optimization of Inhibitors of the 3-Chymotrypsin-like Protease of SARS-CoV-2

Issouf Fofana, Brice Dali, Mawa Koné, Katarina Sujova, Eugene Megnassan, Stanislav Miertus, Vladimir Frecer   +6 more
openalex   +1 more source