Results 41 to 50 of about 3,573,509 (380)

Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against Mpro and cathepsin L

Science Advances, 2020
X-ray crystal structures of SARS-CoV-2 Mpro with dual inhibitors provide a new direction for the designing of COVID-19 antivirals. The main protease (Mpro) of SARS-CoV-2 is a key antiviral drug target. While most Mpro inhibitors have a γ-lactam glutamine
M. Sacco, Chunlong Ma, Panagiotis Lagarias, A. Gao, J. A. Townsend, Xiangzhi Meng, P. Dube, Xiujun Zhang, Yanmei Hu, Naoya Kitamura, B. Hurst, Bart Tarbet, M. Marty, A. Kolocouris, Y. Xiang, Yu Chen, Jun Wang   +16 more
semanticscholar   +1 more source

The protease inhibitors

Primary Care Update for OB/GYNS, 2001
With the advent of newer antiretroviral agents for the treatment of patients with human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS), health care providers are faced with many options to optimize their patients' therapy.
College of Medicine, University of Florida, Gainesville, Florida, USA ( host institution ), Tapp Alter, Karen   +1 more
openaire   +4 more sources

Phenotypic hypersusceptibility to multiple protease inhibitors and low replicative capacity in patients who are chronically infected with human immunodeficiency virus type 1 [PDF]

, 2005
Increased susceptibility to the protease inhibitors saquinavir and amprenavir has been observed in human immunodeficiency virus type 1 (HIV-1) with specific mutations in protease (V82T and N88S).
Clotet, B, Frost, SDW, Leigh Brown, AJ, Martinez-Picado, J, Parkin, NT, Petropoulos, CJ, Ruiz, L, Wrin, T   +7 more
core   +2 more sources

Differences in the Inhibitory Specificity Distinguish the Efficacy of Plant Protease Inhibitors on Mouse Fibrosarcoma

Plants, 2021
Metastasis, the primary cause of death from malignant tumors, is facilitated by multiple protease-mediated processes. Thus, effort has been invested in the development of protease inhibitors to prevent metastasis.
Sonia Yoo Im, Camila Ramalho Bonturi, Adriana Miti Nakahata, Clóvis Ryuichi Nakaie, Arnildo Pott, Vali Joana Pott, Maria Luiza Vilela Oliva   +6 more
doaj   +1 more source

Putative Inhibitors of SARS-CoV-2 Main Protease from A Library of Marine Natural Products: A Virtual Screening and Molecular Modeling Study

Marine Drugs, 2020
The current emergency due to the worldwide spread of the COVID-19 caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a great concern for global public health.
Davide Gentile, Vincenzo Patamia, A. Scala, M. Sciortino, A. Piperno, A. Rescifina   +5 more
semanticscholar   +1 more source

Serpins : form, function and dysfunction [PDF]

, 2013
The serpin superfamily of serine protease inhibitors is one of the most ubiquitous and successful classes of inhibitors in the living world. Their unique mechanism of suicide inhibition has led to much research and several important discoveries.
Cassar, Nicholas J., Hunter, Gary J.
core   +1 more source

An investigation into the identification of potential inhibitors of SARS-CoV-2 main protease using molecular docking study

Journal of Biomolecular Structure and Dynamics, 2020
A new strain of a novel infectious disease affecting millions of people, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently been declared as a pandemic by the World Health Organization (WHO).
Sourav Das, Sharat Sarmah, Sona Lyndem, Atanu Singha Roy   +3 more
semanticscholar   +1 more source

Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]

, 2003
Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Brew K., Kitts P.A., Kos J., Kotzsch M., Lah T.T., Magdolen U., Possee R.D., Rabbani S.A., Reuning U., Stetler-Stevenson W.G., Szpaderska A.M., Thomas C.J.   +11 more
core   +2 more sources

High failure rates of protease inhibitor-based antiretroviral treatment in rural Tanzania - A prospective cohort study.

PLoS ONE, 2020
BACKGROUND:Poor adherence to antiretroviral drugs and viral resistance are the main drivers of treatment failure in HIV-infected patients. In sub-Saharan Africa, avoidance of treatment failure on second-line protease inhibitor therapy is critical as ...
Rahel E Bircher, Alex J Ntamatungiro, Tracy R Glass, Dorcas Mnzava, Amina Nyuri, Herry Mapesi, Daniel H Paris, Manuel Battegay, Thomas Klimkait, Maja Weisser, KIULARCO study group   +10 more
doaj   +1 more source

Interspecific differences between D. pulex and D. magna in tolerance to cyanobacteria with protease inhibitors. [PDF]

PLoS ONE, 2013
It is known that cyanobacteria negatively affect herbivores due to their production of toxins such as protease inhibitors. In the present study we investigated potential interspecific differences between two major herbivores, Daphnia magna and Daphnia ...
Christian J Kuster, Eric Von Elert
doaj   +1 more source