Results 41 to 50 of about 3,925 (50)

Hepatitis C Virus NS3/4A Protease Inhibitors: A Light at the End of the Tunnel

Viruses, 2010
Hepatitis C virus (HCV) infection is a serious and growing threat to human health. The current treatment provides limited efficacy and is poorly tolerated, highlighting the urgent medical need for novel therapeutics.
Laurent Chatel-Chaix, Daniel Lamarre, Martin Baril   +2 more
doaj   +1 more source

Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening

Nature Communications
Variants of SARS-CoV-2 have continued to emerge across the world and cause hundreds of deaths each week. Due to the limited efficacy of vaccines against SARS-CoV-2 and resistance to current therapies, additional anti-viral therapeutics with pan ...
Hengrui Liu, Arie Zask, Farhad Forouhar, Sho Iketani, Alana Williams, Daniel R. Vaz, Dahlya Habashi, Karenna Choi, Samuel J. Resnick, Seo Jung Hong, David H. Lovett, Tian Bai, Alejandro Chavez, David D. Ho, Brent R. Stockwell   +14 more
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Exploring the Potential of Bacillus Species Secondary Metabolites as SARS-CoV-2 Protease Inhibitors

Journal of Pure and Applied Microbiology
Virus has the ability to cause health problems and even death in humans. Therefore, this review aims to assess the potential of metabolites derived from Bacillus species as viral protease inhibitors, specifically targeting Mpro/3CLpro and PLpro, in SARS ...
Yuniar Mulyani, Yeni Mulyani, Mochamad Untung K. Agung, Dian Yuni Pratiwi   +3 more
doaj   +1 more source

The use of telaprevir for the treatment of hepatitis C in patients undergoing liver transplantation (Literature review and clinical experience)

Трансплантология (Москва), 2016
Authors reviewed published data concerning antiviral treatment of liver transplant recipients with 1st generation HCV protease inhibitors (telaprevir and boceprevir).
M. Sh. Khubutiya, V. E. Syutkin, N. I. Geyvandova, A. A. Salienko, T. V. Gudzovskaya, M. S. Novruzbekov   +5 more
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Role of Gag in HIV Resistance to Protease Inhibitors

Viruses, 2010
Cleavage of Gag and Gag-Pol precursors by the viral protease is an essential step in the replication cycle of HIV. Protease inhibitors, which compete with natural cleavage sites, strongly impair viral infectivity and have proven to be highly valuable in ...
Fabrizio Mammano, François Clavel
doaj   +1 more source

Direct-Acting Antivirals for the Treatment of Chronic Hepatitis C: Open Issues and Future Perspectives

The Scientific World Journal, 2013
Currently, two direct-acting antivirals (DAAs) show well-established efficacy against hepatitis C virus (HCV), namely, first-wave protease inhibitors telaprevir and boceprevir. Most clinical trials have examined DAAs in combination with standard of care (
Hee Bok Chae, Seon Mee Park, Sei Jin Youn   +2 more
doaj   +1 more source

Tick cysteine protease inhibitors suppress immune responses in mannan-induced psoriasis-like inflammation

Frontiers in Immunology
Protease inhibitors regulate various biological processes and prevent host tissue/organ damage. Specific inhibition/regulation of proteases is clinically valuable for treating several diseases.
Huimei Wu, Huimei Wu, Mohamed Amine Jmel, Jinwei Chai, Maolin Tian, Xueqing Xu, Xueqing Xu, Yuan Hui, Kutty Selva Nandakumar, Kutty Selva Nandakumar, Michail Kotsyfakis, Michail Kotsyfakis   +11 more
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HIV protease inhibitors: a review of molecular selectivity and toxicity

HIV/AIDS: Research and Palliative Care, 2015
Zhengtong Lv,* Yuan Chu,* Yong Wang Department of Immunology, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China *Both authors contributed equally to this work ...
Lv Z, Chu Y, Wang Y
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The Place of protease inhibitors in antiretroviral treatment

Brazilian Journal of Infectious Diseases
With the introduction of highly active antiretroviral therapy, a number of drugs have been developed. The best choice concerning which antiretroviral analogs to start is always under discussion, especially in the choice between non-nucleoside reverse ...
S.B. Tenore, P.R.A. Ferreira
doaj   +1 more source

The effects of protease inhibitors on basal and insulin-stimulated lipid metabolism, insulin binding, and signaling

Journal of Lipid Research, 2003
The objective of our research was to investigate the effects of the protease inhibitors ritonavir, saquinavir, and indinavir on triglyceride synthesis, lipolysis, insulin binding, and signaling in differentiating 3T3 L1 pre-adipocytes.
Catarina Cammalleri, Ralph J. Germinario
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