Results 21 to 30 of about 793,529 (384)

Protease inhibitors targeting coronavirus and filovirus entry. [PDF]

, 2015
In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases.
Agudelo, Juliet, Barnard, Dale, Carrion, Ricardo, Lu, Kai, McKerrow, James H, Nunneley, Jerritt W, Pöhlmann, Stefan, Renslo, Adam R, Simmons, Graham, Vedantham, Punitha, Zhou, Yanchen   +10 more
core   +1 more source

SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties. [PDF]

, 2018
BackgroundSerine proteases are important virulence factors for many pathogens. Recently, we discovered a group of trypsin-like serine proteases with domain organization unique to flatworm parasites and containing a thrombospondin type 1 repeat (TSR-1 ...
Caffrey, Conor R, Chanová, Marta, Craik, Charles S, Dvořák, Jan, Fajtová, Pavla, Horn, Martin, Hubálek, Martin, Jiang, Zhenze, Leontovyč, Adrian, Mareš, Michael, Marešová, Lucie, O'Donoghue, Anthony J, Ulrychová, Lenka, Vondrášek, Jiří   +13 more
core   +7 more sources

Effect of accumulated resistance genes to Puccinia triticina on transfer of seed proteins [PDF]

Ratarstvo i Povrtarstvo, 2013
Eighteen wheat lines and varieties were classified in four groups according to different reactions to Puccinia triticina isolate of the race 77 at seedlings.
Jerković Zoran, Prijić Željana, Đurić Veselinka   +2 more
doaj   +1 more source

Pollens destroy respiratory epithelial cell anchors and drive alphaherpesvirus infection [PDF]

, 2019
Pollens are well-known triggers of respiratory allergies and asthma. The pollen burden in today's ambient air is constantly increasing due to rising climate change and air pollution.
Gevaert, Kris, Impens, Francis, Laval, Kathlyn, Nauwynck, Hans, Poelaert, Katrien, Van Cleemput, Jolien, Van Den Broeck, Wim   +6 more
core   +3 more sources

Tumor-Associated Macrophages Derived from Circulating Inflammatory Monocytes Degrade Collagen through Cellular Uptake

Cell Reports, 2017
Physiologic turnover of interstitial collagen is mediated by a sequential pathway in which collagen is fragmented by pericellular collagenases, endocytosed by collagen receptors, and routed to lysosomes for degradation by cathepsins.
Daniel Hargbøl Madsen, Henrik Jessen Jürgensen, Majken Storm Siersbæk, Dorota Ewa Kuczek, Loretta Grey Cloud, Shihui Liu, Niels Behrendt, Lars Grøntved, Roberto Weigert, Thomas Henrik Bugge   +9 more
doaj   +1 more source

Purification and characterization of a protease from Aspergillus sydowii URM5774: Coffee ground residue for protease production by solid state fermentation

Anais da Academia Brasileira de Ciências, 2021
Solid state fermentation is a promising technology largely used in biotechnology process and is a suitable strategy for producing low-cost enzymatic products.
FELYPE T.B. ROCHA, ROMERO M.P. BRANDÃO-COSTA, ANNA GABRIELLY D. NEVES, KETHYLEN B.B. CARDOSO, THIAGO P. NASCIMENTO, WENDELL W.C. ALBUQUERQUE, ANA LÚCIA F. PORTO   +6 more
doaj   +1 more source

The role of proteases in pathologies of the synovial joint [PDF]

, 2008
Synovial (diarthrodial) joints are employed within the body to provide skeletal mobility and have a characteristic structure adapted to provide a smooth almost frictionless surface for articulation.
Buttle, D, Jones, GC, Riley, GP
core   +1 more source

Sustainable Upcycling of Fisheries and Aquaculture Wastes Using Fish-Derived Cold-Adapted Proteases

Frontiers in Nutrition, 2022
The fisheries and aquaculture industries are some of the major economic sectors in the world. However, these industries generate significant amounts of wastes that need to be properly managed to avoid serious health and environmental issues.
Zied Khiari
doaj   +1 more source

Roles and regulation of membrane-associated serine proteases [PDF]

, 2007
Pericellular proteolytic activity affects many aspects of cellular behaviour, via mechanisms involving processing of the extracellular matrix, growth factors and receptors.
Bass, Rosemary, Ellis, V, Gray, Kelly, Owen, K, Qiu, Deyi   +4 more
core   +1 more source

Targeting host cell proteases as a potential treatment strategy to limit the spread of SARS‐CoV‐2 in the respiratory tract

Pharmacology Research & Perspectives, 2021
As the death toll of Coronavirus disease 19 (COVID‐19) continues to rise worldwide, it is imperative to explore novel molecular mechanisms for targeting SARS‐CoV‐2.
Ismail A. El‐Shimy, Mahmoud M. A. Mohamed, Syed Shahzad Hasan, Muhammad A. Hadi   +3 more
doaj   +1 more source