Results 1 to 10 of about 135,989 (116)

Regulation of TRIB1 abundance in hepatocyte models in response to proteasome inhibition [PDF]

Scientific Reports, 2023
Tribbles related homolog 1 (TRIB1) contributes to lipid and glucose homeostasis by facilitating the degradation of cognate cargos by the proteasome. In view of the key metabolic role of TRIB1 and the impact of proteasome inhibition on hepatic function ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
doaj   +2 more sources

The aspartyl protease DDI2 drives adaptation to proteasome inhibition in multiple myeloma [PDF]

Cell Death and Disease, 2022
Proteasome inhibitors, such as bortezomib, are first-line therapy against multiple myeloma (MM). Unfortunately, patients frequently become refractory to this treatment.
Mélanie Op, Sérgio T. Ribeiro, Claire Chavarria, Aude De Gassart, Léa Zaffalon, Fabio Martinon   +5 more
doaj   +2 more sources

Combined inhibition of p97 and the proteasome causes lethal disruption of the secretory apparatus in multiple myeloma cells.

PLoS ONE, 2013
Inhibition of the proteasome is a widely used strategy for treating multiple myeloma that takes advantage of the heavy secretory load that multiple myeloma cells (MMCs) have to deal with.
Holger W Auner, Anne Marie Moody, Theresa H Ward, Marianne Kraus, Enrico Milan, Philippa May, Aristeidis Chaidos, Christoph Driessen, Simone Cenci, Francesco Dazzi, Amin Rahemtulla, Jane F Apperley, Anastasios Karadimitris, Niall Dillon   +13 more
doaj   +2 more sources

Modulation of CREB3L2-ATF4 heterodimerization via proteasome inhibition and HRI activation in Alzheimer’s disease pathology [PDF]

Cell Death and Disease
Alzheimer’s disease (AD) pathology includes transcriptional changes in the neurons, which are in part caused by the heterodimerization of two stress response transcription factors, CREB3L2 and ATF4.
Krystal Herline-Killian, Michaela M. Pauers, Jessica E. Lipponen, Michael A. Zrzavy, Cláudio Gouveia Roque, Ethan P. McCurdy, Kyung Min Chung, Ulrich Hengst   +7 more
doaj   +2 more sources

Synaptic proteasome is inhibited in Alzheimer’s disease models and associates with memory impairment in mice

Communications Biology, 2023
The proteasome plays key roles in synaptic plasticity and memory by regulating protein turnover, quality control, and elimination of oxidized/misfolded proteins. Here, we investigate proteasome function and localization at synapses in Alzheimer’s disease
Felipe C. Ribeiro, Danielle Cozachenco, Luana Heimfarth, Juliana T. S. Fortuna, Guilherme B. de Freitas, Jorge M. de Sousa, Soniza V. Alves-Leon, Renata E. P. Leite, Claudia K. Suemoto, Lea T. Grinberg, Fernanda G. De Felice, Mychael V. Lourenco, Sergio T. Ferreira   +12 more
doaj   +1 more source

Autophagic sequestration of SQSTM1 disrupts the aggresome formation of ubiquitinated proteins during proteasome inhibition

Cell Death and Disease, 2022
Aggresome formation is a protective cellular response to counteract proteasome dysfunction by sequestering misfolded proteins and reducing proteotoxic stress.
Chenliang Zhang, Chen Huang, Hongwei Xia, Huanji Xu, Qiulin Tang, Feng Bi   +5 more
doaj   +1 more source

Proteasome inhibition represses unfolded protein response and Nox4, sensitizing vascular cells to endoplasmic reticulum stress-induced death. [PDF]

PLoS ONE, 2011
BACKGROUND: Endoplasmic reticulum (ER) stress has pathophysiological relevance in vascular diseases and merges with proteasome function. Proteasome inhibition induces cell stress and may have therapeutic implications.
Angélica M Amanso, Victor Debbas, Francisco R M Laurindo   +2 more
doaj   +1 more source

Inhibition of SQSTM1 S403 phosphorylation facilitates the aggresome formation of ubiquitinated proteins during proteasome dysfunction

Cellular & Molecular Biology Letters, 2023
Background Ubiquitin–proteasome-system-mediated clearance of misfolded proteins is essential for cells to maintain proteostasis and reduce the proteotoxicity caused by these aberrant proteins.
Chenliang Zhang, YiChun Duan, Chen Huang, Liping Li   +3 more
doaj   +1 more source

Different effect of proteasome inhibition on vesicular stomatitis virus and poliovirus replication. [PDF]

PLoS ONE, 2008
Proteasome activity is an important part of viral replication. In this study, we examined the effect of proteasome inhibitors on the replication of vesicular stomatitis virus (VSV) and poliovirus.
Nickolay Neznanov, Eugenia M Dragunsky, Konstantin M Chumakov, Lubov Neznanova, Ronald C Wek, Andrei V Gudkov, Amiya K Banerjee   +6 more
doaj   +1 more source

Niclosamide prevents the formation of large ubiquitin-containing aggregates caused by proteasome inhibition. [PDF]

PLoS ONE, 2010
Protein aggregation is a hallmark of many neurodegenerative diseases and has been linked to the failure to degrade misfolded and damaged proteins. In the cell, aberrant proteins are degraded by the ubiquitin proteasome system that mainly targets short ...
Esther Gies, Inga Wilde, Jason M Winget, Maria Brack, Barak Rotblat, Carolina Arias Novoa, Aruna D Balgi, Poul H Sorensen, Michel Roberge, Thibault Mayor   +9 more
doaj   +1 more source