Results 11 to 20 of about 469,365 (378)

Genetic Construction of Bacillus subtilis Recombinant Strain, Producing Protective Antigen of Anthrax Microbe

Вестник войск РХБ защиты, 2023
Anthrax is a serious infectious disease with high mortality. The epidemiological security depends on the vaccination of susceptible animals and population at risk.
N. V. Onuchina, A. V. Kuznetsovsky, A. A. Vorobyov, A. V. Filippov   +3 more
doaj   +1 more source

Antigenic identity of immunodominant proteins of Bacillus anthracis genovariants

Журнал микробиологии, эпидемиологии и иммунобиологии, 2023
Introduction. The main biological raw materials for the production of immunobiological preparations for identification of Bacillus anthracis are its specific antigens, the protective antigen and the EA1 protein. Purpose.
Margarita P. Izhberdeeva, Anastasiya A. Sautkina, Irina A. Barkova, Dmitry V. Viktorov   +3 more
doaj   +1 more source

Binding Sites of Anti-Lcr V Monoclonal Antibodies Are More Critical than the Avidities and Affinities for Passive Protection against Yersinia pestis Infection in a Bubonic Plague Model

Antibodies, 2020
Plague is a zoonotic disease that is caused by Yersinia pestis. Monoclonal antibodies (mAbs) that bind to the V-antigen, a virulence factor that is produced by Y. pestis, can passively protect mice from plague. An analysis of protective mAbs that bind to
Kei Amemiya, Jennifer L. Dankmeyer, Sarah L. Keasey, Sylvia R. Trevino, Michael M. Wormald, Stephanie A. Halasohoris, Wilson J. Ribot, David P. Fetterer, Christopher K. Cote, Patricia L. Worsham, Jeffrey J. Adamovicz, Robert G. Ulrich   +11 more
doaj   +1 more source

Current understanding of Bacillus anthracis toxin molecules organization and approaches for blocking their cytotoxic action

Инфекция и иммунитет, 2020
Here, we review the data on mechanisms inhibiting cytotoxic effect of anthrax toxin on the immune system cells. Various disease forms, immunopathogenesis and contemporary methods for anthrax treatment are discussed.
V. V. Firstova, I. G. Shemyakin, I. A. Dyatlov   +2 more
doaj   +1 more source

New protective antigen of group A streptococci [PDF]

Journal of Clinical Investigation, 1999
It is widely believed that the surface M protein of group A streptococci is the predominant surface protein of these organisms containing opsonic epitopes. In the present study, we identified a new surface protein, distinct from M protein, that evokes protective antibodies.
J B, Dale, E Y, Chiang, S, Liu, H S, Courtney, D L, Hasty   +4 more
openaire   +3 more sources

DNA Vaccines Encoding Antigen Targeted to MHC Class II Induce Influenza-Specific CD8+ T Cell Responses, Enabling Faster Resolution of Influenza Disease [PDF]

, 2016
Current influenza vaccines are effective but imperfect, failing to cover against emerging strains of virus and requiring seasonal administration to protect against new strains. A key step to improving influenza vaccines is to improve our understanding of
Bogen, B, Brunsvik Frediksen, A, Grodeland, G, Kinnear, E, Lambert, L, Lindberg, MM, Mcdonald, JU, Stubsrud, E, Tregoning, JS   +8 more
core   +7 more sources

Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity [PDF]

, 2012
Decline of cell-mediated immunity is often attributed to decaying T-cell numbers and their distribution in peripheral organs. This study examined the hypothesis that qualitative as well as quantitative changes contribute to the declining efficacy of CD8+
Alexander-Miller, Almeida, Appay, Berger, Betts, Bosselut, Cerundolo, Gallimore, Gorman, Hansen, Hollander, Homann, Jelley-Gibbs, Jenkins, Jones, Jones, Judge, Karrer, Kattan, Kedzierska, Kim, Kohlmeier, Lefranc, Liang, Moffat, Neveu, Norbury, Powell, Price, Quigley, Rangel-Moreno, Richards, Roberts, Schluns, Tan, Tough, Trautmann, Valkenburg, Valkenburg, Woodland, Wooldridge, Zammit   +41 more
core   +1 more source

Why is a protective antigen protective?

Human Vaccines, 2009
One of the major challenges in vaccine development is the identification of microbial components that give rise to a protective immune response. Over the last decade, genome and proteome-based methods have proven successful in discovering new vaccine candidates for many pathogens through the selection of secreted or surface-exposed protein antigens and
L.J. Gourlay, G. Colombo, M. Soriani, G. Grandi, X. Daura, M. Bolognesi   +5 more
openaire   +8 more sources

Anthrax Toxin Detection: From In Vivo Studies to Diagnostic Applications

Microorganisms, 2020
Anthrax toxins are produced by Bacillus anthracis throughout infection and shape the physiopathogenesis of the disease. They are produced in low quantities but are highly efficient.
Jean-Nicolas Tournier, Clémence Rougeaux   +1 more
doaj   +1 more source

Evaluation of Cellular Immunity with ASFV Infection by Swine Leukocyte Antigen (SLA)—Peptide Tetramers

Viruses, 2021
African swine fever virus (ASFV) causes acute hemorrhagic fever in domestic pigs and wild boars, resulting in incalculable economic losses to the pig industry. As the mechanism of viral infection is not clear, protective antigens have not been discovered
Wenqiang Sun, He Zhang, Wenhui Fan, Lihong He, Teng Chen, Xintao Zhou, Yu Qi, Lei Sun, Rongliang Hu, Tingrong Luo, Wenjun Liu, Jing Li   +11 more
doaj   +1 more source