Results 21 to 30 of about 469,365 (378)
Identification of protective T-cell antigens for smallpox vaccines [PDF]
Cytotherapy, 2020 E3L is an immediate-early protein of vaccinia virus (VV) that is detected within 0.5 h of infection, potentially before the many immune evasion genes of vaccinia can exert their protective effects. E3L is highly conserved among orthopoxviruses and hence could provide important protective T-cell epitopes that should be retained in any subunit or ...
Ann M. Leen +6 more
openaire +2 more sources
Pathogens, 2023 Bacillus cereus is ubiquitous in the environment and a well-known causative agent of foodborne disease. Surprisingly, more and more emerging strains of atypical B.
Jia-Ming Tsai +2 more
doaj +1 more source
Vaccine development against tuberculosis before and after Covid-19
Frontiers in Immunology, 2023 Coronavirus disease (Covid-19) has not only shaped awareness of the impact of infectious diseases on global health. It has also provided instructive lessons for better prevention strategies against new and current infectious diseases of major importance.
Stefan H. E. Kaufmann +2 more
doaj +1 more source
Mathematical Modeling Insights into Improving CAR T cell Therapy for Solid Tumors: Antigen Heterogeneity and Bystander Effects [PDF]
npj Systems Biology and Applications, 10(1), 105 (2024), 2023 As an adoptive cellular therapy, Chimeric Antigen Receptor T-cell (CAR T-cell) therapy has shown remarkable success in hematological malignancies, but only limited efficacy against solid tumors. Compared with blood cancers, solid tumors present a unique set of challenges that ultimately neutralize the function of CAR T-cells.
arxiv +1 more source
Simultaneous immunization with Omp25 and L7/L12 provides protection against brucellosis in mice [PDF]
, 2020 Currently ...
Aggarwal, Somya +4 more
core +2 more sources
Antigens of Bordetella pertussis.III. The Protective Antigen
Experimental Biology and Medicine, 1963 SummaryA method of preparing extracts from Bordetella pertussis with high protective and histamine sensitizing activity is described. From these extracts, starch block electrophoresis yielded active purified fractions which not only protected mice against intracerebral challenge with living B. pertussis cells but also sensitized mice to histamine. From
B. M. Hestekin, J. Munoz
openaire +3 more sources
Toxins, 2013 Inhaled Bacillus anthracis spores germinate and the subsequent vegetative growth results in bacteremia and toxin production. Anthrax toxin is tripartite: the lethal factor and edema factor are enzymatic moieties, while the protective antigen (PA) binds ...
Cecil Chen +6 more
doaj +1 more source
Development of a New Cell-Based AP-1 Gene Reporter Potency Assay for Anti-Anthrax Toxin Therapeutics
Toxins, 2023 Anthrax toxin is a critical virulence factor of Bacillus anthracis. The toxin comprises protective antigen (PA) and two enzymatic moieties, edema factor (EF) and lethal factor (LF), forming bipartite lethal toxin (LT) and edema toxin (ET).
Weiming Ouyang +3 more
doaj +1 more source
Recombinant HSA-CMG2 Is a Promising Anthrax Toxin Inhibitor
Toxins, 2016 Anthrax toxin is the major virulence factor produced by Bacillus anthracis. Protective antigen (PA) is the key component of the toxin and has been confirmed as the main target for the development of toxin inhibitors.
Liangliang Li +8 more
doaj +1 more source
Toxins, 2016 Nearly all the cationic molecules tested so far have been shown to reversibly block K+ current through the cation-selective PA63 channels of anthrax toxin in a wide nM–mM range of effective concentrations.
Goli Yamini +2 more
doaj +1 more source