Molecular Systems Biology, 2015 Mitogen‐activated protein kinases (MAPK) are broadly used regulators of cellular signaling. However, how these enzymes can be involved in such a broad spectrum of physiological functions is not understood.
András Zeke +8 more
doaj +1 more source
Predicting protein phenotypes based on protein-protein interaction network. [PDF]
PLoS ONE, 2011 BackgroundIdentifying associated phenotypes of proteins is a challenge of the modern genetics since the multifactorial trait often results from contributions of many proteins.
Lele Hu +3 more
doaj +1 more source
MAPPI-DAT : data management and analysis for protein-protein interaction data from the high-throughput MAPPIT cell microarray platform [PDF]
, 2017 Protein-protein interaction (PPI) studies have dramatically expanded our knowledge about cellular behaviour and development in different conditions. A multitude of high-throughput PPI techniques have been developed to achieve proteome-scale coverage for ...
De Puysseleyr, Veronic +8 more
core +1 more source
Comparative Analysis of the Saccharomyces cerevisiae and Caenorhabditis elegans Protein Interaction Network [PDF]
, 2005 Protein interaction networks aim to summarize the complex interplay of proteins in an organism. Early studies suggested that the position of a protein in the network determines its evolutionary rate but there has been considerable disagreement as to what
Abbott, James +5 more
core +5 more sources
DCSE:Double-Channel-Siamese-Ensemble model for protein protein interaction prediction
BMC Genomics, 2022 Background Protein-protein interaction (PPI) is very important for many biochemical processes. Therefore, accurate prediction of PPI can help us better understand the role of proteins in biochemical processes.
Wenqi Chen +5 more
doaj +1 more source
Relation Extraction of Protein Complexes from Dynamic Protein-Protein Interaction Network [PDF]
Journal of Biomedical Physics and Engineering, 2021 Background: Dynamic protein-protein interaction networks (DPPIN) can confirm the conditional and temporal features of proteins and protein complexes. In addition, the relation of protein complexes in dynamic networks can provide useful information in ...
Moslem Mohammadi Jenghara +2 more
doaj +1 more source
Uncovering protein interaction in abstracts and text using a novel linear model and word proximity networks [PDF]
, 2008 We participated in three of the protein-protein interaction subtasks of the Second BioCreative Challenge: classification of abstracts relevant for protein-protein interaction (IAS), discovery of protein pairs (IPS) and text passages characterizing ...
Abi-Haidar, Alaa +7 more
core +4 more sources
A scored human protein–protein interaction network to catalyze genomic interpretation
Nature Methods, 2017 Genome-scale human protein–protein interaction networks are critical to understanding cell biology and interpreting genomic data, but challenging to produce experimentally.
Olga Rigina +1 more
semanticscholar +2 more sources
Alpha influenza virus infiltration prediction using virus-human protein-protein interaction network
Mathematical Biosciences and Engineering, 2020 More than ten million deaths make influenza virus one of the deadliest of history. About half a million sever illnesses are annually reported consequent of influenza. Influenza is a parasite which needs the host cellular machinery to replicate its genome.
Babak Khorsand +3 more
doaj +1 more source
Memory in repetitive protein–protein interaction series
APL Bioengineering, 2023 Interactions between proteins coordinate biological processes in an organism and may impact its responses to changing environments and diseases through feedback systems. Feedback systems function by using changes in the past to influence behaviors in the
Aaron M. Rosado +8 more
doaj +1 more source