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A simple but efficient electrochemical method to assay protein arginine deiminase 4
Sensors and Actuators B: Chemical, 2016Abstract Nowadays, protein arginine deiminase 4 (PAD4) has become a potential therapeutic target for human diseases, especially in rheumatoid arthritis (RA) patients. In this paper, we have reported a simple but efficient electrochemical method to assay protein arginine deiminase 4 (PAD4) activities and screen its inhibitors.
Xixian Chen +4 more
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Theoretical study of the mechanism of protein arginine deiminase 4 (PAD4) inhibition by F-amidine
Journal of Molecular Graphics and Modelling, 2015Protein arginine deiminase 4 (PAD4) catalyzes the hydrolysis of a peptidylarginine residue to form a citrulline residue and ammonia during posttranslational modification. This process plays a pivotal role in rheumatoid arthritis (RA) and gene regulation. F-amidine belongs to a series of haloacetamidine compounds that are the most potent PAD4 inhibitors
Dongmei, Li, Cui, Liu, Jianping, Lin
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Journal of Medicinal Chemistry, 2017
Peptidyl arginine deiminases have been shown to be hyperactive in neurodegenerative diseases including multiple sclerosis. An α-amino acid-based core structure, derived from a hydantoin core, with unique heterocycles on the side chains were synthesized as potential noncovalent inhibitors of PAD enzymes.
Elizabeth J. Curiel Tejeda +5 more
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Peptidyl arginine deiminases have been shown to be hyperactive in neurodegenerative diseases including multiple sclerosis. An α-amino acid-based core structure, derived from a hydantoin core, with unique heterocycles on the side chains were synthesized as potential noncovalent inhibitors of PAD enzymes.
Elizabeth J. Curiel Tejeda +5 more
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Peptidyl arginine deiminases: detection and functional analysis of protein citrullination
Current Opinion in Structural Biology, 2019Ronak Tilvawala, Paul R Thompson
exaly
Small-molecule Modulators of Protein Arginine Deiminases (PAD)
2016Aaron Muth +3 more
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[Peptidylarginine deiminase, protein-arginine deiminase and protein-L-arginine iminohydrolase].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1987H, Takahara, K, Sugawara
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