Results 41 to 50 of about 798,140 (253)
Decoding RNA–protein interactions using high-throughput methods
RNA BiologyRNA-binding proteins (RBPs) constitute a diverse class of proteins essential for every stage of the gene expression process. Many RBPs are also linked to human diseases and pathologies.
Marianne Régis +2 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Endogenous ZAP is associated with altered Zika virus infection phenotype
Virology JournalThe zinc finger antiviral protein 1 (ZAP) has broad antiviral activity. ZAP is an interferon (IFN)-stimulated gene, which itself may enhance type I IFN antiviral response.
Nguyen Phuong Khanh Le +4 more
doaj +1 more source
Microbiology SpectrumKaposi’s sarcoma-associated herpesvirus (KSHV) DNA polymerase processivity factor, ORF59, is a lytic protein essential for viral DNA synthesis as part of the core replication complex.
Shannon Harger Payen +4 more
doaj +1 more source
Bio-Protocol, 2017 RNA-Protein interactions play important roles in various eukaryotic biological processes. Molecular imaging of subcellular localization of RNA/protein complexes in plants is critical for understanding these interactions.
Jun Sung Seo, Nam-Hai Chua
doaj +1 more source
Going beyond Integration: The Emerging Role of HIV-1 Integrase in Virion Morphogenesis
Viruses, 2020 The HIV-1 integrase enzyme (IN) plays a critical role in the viral life cycle by integrating the reverse-transcribed viral DNA into the host chromosome. This function of IN has been well studied, and the knowledge gained has informed the design of small ...
Jennifer L. Elliott, Sebla B. Kutluay
doaj +1 more source
Dynamic protein-RNA interactions in mediating splicing catalysis. [PDF]
Nucleic Acids Res, 2019 The spliceosome is assembled via sequential interactions of pre-mRNA with five small nuclear RNAs and many proteins. Recent determination of cryo-EM structures for several spliceosomal complexes has provided deep insights into interactions between spliceosomal components and structural changes of the spliceosome between steps, but information on how ...
Chung CS +5 more
europepmc +3 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Dissection and prediction of RNA-binding sites on proteins
Biomolecular Concepts, 2010 RNA-binding proteins are involved in many important regulatory processes in cells and their study is essential for a complete understanding of living organisms. They show a large variability from both structural and functional points of view.
Pérez-Cano Laura, Fernández-Recio Juan
doaj +1 more source
Molecular and Biochemical Techniques for Deciphering p53-MDM2 Regulatory Mechanisms
Biomolecules, 2020 The p53 and Mouse double minute 2 (MDM2) proteins are hubs in extensive networks of interactions with multiple partners and functions. Intrinsically disordered regions help to adopt function-specific structural conformations in response to ligand binding
Konstantinos Karakostis +4 more
doaj +1 more source