Results 11 to 20 of about 11,665,453 (372)
UniProt: the universal protein knowledgebase in 2021
Nucleic Acids Res., 2020 The aim of the UniProt Knowledgebase is to provide users with a comprehensive, high-quality and freely accessible set of protein sequences annotated with functional information.
A. Bateman +132 more
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Evolutionary-scale prediction of atomic level protein structure with a language model
bioRxiv, 2022 Artificial intelligence has the potential to open insight into the structure of proteins at the scale of evolution. It has only recently been possible to extend protein structure prediction to two hundred million cataloged proteins.
Zeming Lin +14 more
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A human bispecific antibody neutralizes botulinum neurotoxin serotype A
Scientific Reports, 2023 Botulinum neurotoxin (BoNT) shows high lethality and toxicity, marking it as an important biological threat. The only effective post-exposure therapy is botulinum antitoxin; however, such products have great potential for improvement. To prevent or treat
Jiansheng Lu +10 more
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Physchem, 2023 Amyloid formation is linked with serious human diseases that are currently incurable. Usually, in the study of amyloid aggregation, the description of the protein’s association is in focus.
Victor Marchenkov +7 more
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Structural mechanism of laminin recognition by integrin
Nature Communications, 2021 Recognition of laminin by integrin receptors mediates epithelial cell adhesion to basement membrane. Here, the structures of the α6β1 integrin alone and in complex with three-chain laminin-511 fragment reveal the laminin-integrin interface in molecular ...
Takao Arimori +7 more
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Influence of Amino Acid Substitutions in ApoMb on Different Stages of Unfolding of Amyloids
Molecules, 2023 To date, most research on amyloid aggregation has focused on describing the structure of amyloids and the kinetics of their formation, while the conformational stability of fibrils remains insufficiently explored.
Natalya Katina +6 more
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Communications Biology, 2021 Çoruh, Frank et al. report the structure of monomeric Photosystem I from cyanobacteria Thermosynechoccocus elongatus BP-1. They assign monomerization-induced loss of red chlorophylls to a cluster of chlorophylls adjacent to PsaX.
Orkun Çoruh +9 more
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Proteins, proteins everywhere [PDF]
Science, 2021 The first protein structures were determined by x-ray crystallography in 1957 by John C. Kendrew and Max F. Perutz. As a bioinorganic chemist, I was delighted that the structures were myoglobin and hemoglobin, both heme proteins with big, beautiful iron atoms.
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Application of fourier transform and proteochemometrics principles to protein engineering
BMC Bioinformatics, 2018 Background Connecting the dots between the protein sequence and its function is of fundamental interest for protein engineers. In-silico methods are useful in this quest especially when structural information is not available.
Frédéric Cadet +6 more
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Contextualized Protein-Protein Interactions [PDF]
Patterns, 2021 Protein-protein interaction (PPI) databases are an important bioinformatics resource, yet existing literature-curated databases usually represent cell-type-agnostic interactions, which is at variance with our understanding that protein dynamics are context specific and highly dependent on their environment.
Anthony Federico, Stefano Monti
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