A Novel Sequence-Based Antigenic Distance Measure for H1N1, with Application to Vaccine Effectiveness and the Selection of Vaccine Strains [PDF]
, 2011 H1N1 influenza causes substantial seasonal illness and was the subtype of the 2009 influenza pandemic. Precise measures of antigenic distance between the vaccine and circulating virus strains help researchers design influenza vaccines with high vaccine ...
Brown +16 more
core +3 more sources
Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins
Nature Communications, 2021 RaPID (Random non-standard Peptides Integrated Discovery) enables discovery of small macrocyclic peptides binding desired targets. Here, the authors propose lasso-grafting: the RaPID-derived peptides are implanted onto diverse proteins and maintain both ...
Emiko Mihara +12 more
doaj +1 more source
Near-Wall Aggregation of Amyloidogenic Aβ 1-40 Peptide: Direct Observation by the FRET
Molecules, 2021 The formation of amyloid fibrils is one of the variants of the self-organization of polypeptide chains. For the amyloid aggregation, the solution must be oversaturated with proteins.
Natalia Katina +4 more
doaj +1 more source
Modulators of Protein–Protein Interactions [PDF]
Chemical Reviews, 2014 No ...
Lech-Gustav Milroy +4 more
openaire +4 more sources
Green protein from locally grown crops (OK-Net EcoFeed Practice Abstract) [PDF]
, 2020 • Choose an appropriate type of green crop, such as clover-grass or alfalfa, with an expected high protein and amino acid content. Consider soil types and weather patterns to grow a crop with a good and high quality yield. • Harvest the field at regular
Ambye-Jensen, Morten +2 more
core
Protein-Protein Affinity Determination by Quantitative FRET Quenching. [PDF]
, 2019 The molecular dissociation constant, Kd, is a well-established parameter to quantitate the affinity of protein-protein or other molecular interactions.
Chen, Younan +7 more
core +2 more sources
Side-chain conformational changes upon protein-protein association [PDF]
, 2010 Conformational changes upon protein-protein association are the key element of the binding mechanism. The study presents a systematic large-scale analysis of such conformational changes in the side chains.
Kirys, Tatsiana +3 more
core +2 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Mitochondrial protein import [PDF]
, 1994 The transport of nuclear-encoded proteins from the cytosol into mitochondria is mediated by targeting (signal) sequences present on precursor forms.
Neupert, Walter, Schwarz, Elisabeth
core +1 more source
Entropy in protein folding and in protein—protein interactions
Current Opinion in Structural Biology, 1997 The reduction of conformational entropy is a major barrier that has to be overcome in protein folding and binding. Changes in solvent entropy are also a major factor. Recent advances include clarification of the fundamental issues concerning the separation of entropy into components, the treatment of association entropy in binding, and the role of size
Kim A. Sharp, G.Patrick Brady
openaire +2 more sources