Results 41 to 50 of about 11,665,453 (372)
Nature Communications, 2019 In Pseudomonas aeruginosa, MexAB–OprM plays a central role in multidrug resistance by ejecting various drug compounds. Here the authors present the structure of wild-type MexAB–OprM in the presence or absence of drugs and propose mechanisms for complex ...
Kenta Tsutsumi +7 more
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Cryo-EM demonstrates the in vitro proliferation of an ex vivo amyloid fibril morphology by seeding
Nature Communications, 2022 Here, the authors present the cryo-EM structure of in vitro amyloid fibrils from recombinant SAA1.1 protein that were formed by seeding with fibrils purified from systemic AA amyloidosis tissue.
Thomas Heerde +12 more
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KEGG as a reference resource for gene and protein annotation
Nucleic Acids Res., 2015 KEGG (http://www.kegg.jp/ or http://www.genome.jp/kegg/) is an integrated database resource for biological interpretation of genome sequences and other high-throughput data.
M. Kanehisa +4 more
semanticscholar +1 more source
Accurate prediction of protein structures and interactions using a 3-track neural network
Science, 2021 Deep learning takes on protein folding In 1972, Anfinsen won a Nobel prize for demonstrating a connection between a protein's amino acid sequence and its three-dimensional structure.
Baek M +31 more
semanticscholar +1 more source
INTRINSIC PROTEIN DISORDER AND PROTEIN-PROTEIN INTERACTIONS [PDF]
Biocomputing 2012, 2011 Intrinsically disordered proteins often bind to more than one partner. In this study, we focused on 11 sets of complexes in which the same disordered segment becomes bound to two or more distinct partners. For this collection of protein complexes, two or more partners of each disordered segment were selected to have less than 25% amino acid identity ...
Bin Xue +7 more
openaire +4 more sources
In silico evidence that protein unfolding is as a precursor of the protein aggregation [PDF]
ChemPhysChem 2020, 21, 377, 2019 We present a computational study on the folding and aggregation of proteins in aqueous environment, as function of its concentration. We show how the increase of the concentration of individual protein species can induce a partial unfolding of the native conformation without the occurrence of aggregates. A further increment of the protein concentration
arxiv +1 more source
Nature Communications, 2016 Viruses interact with their hosts via secreted and membrane-bound proteins to affect host immune responses and virulence. Here the authors contribute to our understanding of this relationship with an extracellular interaction map of human and adenoviral ...
Nadia Martinez-Martin +11 more
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Predicting Antibody Developability Profiles Through Early Stage Discovery Screening
mAbs, 2020 Monoclonal antibodies play an increasingly important role for the development of new drugs across multiple therapy areas. The term ‘developability’ encompasses the feasibility of molecules to successfully progress from discovery to development via ...
Marc Bailly +21 more
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Structure of cyanobacterial photosystem I complexed with ferredoxin at 1.97 Å resolution
Communications Biology, 2022 In order to aid the understanding of the electron transfer process within the cyanobacterial photosystem I, its structure - when complexed with Ferredoxin - is determined at 1.97 Å resolution.
Jiannan Li +10 more
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A novel methodology on distributed representations of proteins using their interacting ligands [PDF]
Bioinformatics 2018, 2018 The effective representation of proteins is a crucial task that directly affects the performance of many bioinformatics problems. Related proteins usually bind to similar ligands. Chemical characteristics of ligands are known to capture the functional and mechanistic properties of proteins suggesting that a ligand based approach can be utilized in ...
arxiv +1 more source