Results 71 to 80 of about 287,910 (304)
Artificial Hsp104-mediated systems for re-localizing protein aggregates
, 2023 Spatial Protein Quality Control (sPQC) sequesters misfolded proteins into specific, organelle-associated inclusions within the cell to control their toxicity.
Angela Johns +16 more
core +1 more source
Emerging Therapies in Neurodegenerative Diseases: Targeting Protein Aggregates
, 2023 Neurodegenerative diseases represent a group of debilitating conditions characterized by the progressive degeneration of neurons, resulting in cognitive and motor impairments.
Kausru Dirwieu
core +3 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Golgi Fragmentation in Neurodegenerative Diseases: Is There a Common Cause?
Cells, 2019 In most mammalian cells, the Golgi complex forms a continuous ribbon. In neurodegenerative diseases, the Golgi ribbon of a specific group of neurons is typically broken into isolated elements, a very early event which happens before clinical and other ...
José Ángel Martínez-Menárguez +3 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Formation of whey protein aggregates by partial hydrolysis and reduced thermal treatment
, 2022 Thermal treatment to form functional, soluble whey protein aggregates often generates undesired off-flavours. The aim of the present study was to generate soluble aggregates of whey protein isolates (WPI) at lower temperature than traditionally used by ...
Lund, Marianne N. +3 more
core +1 more source
PROBING BIOPHYSICAL PROPERTIES OF THERAPEUTIC PROTEIN AGGREGATES WITH INTERFEROMETRIC SCATTERING MICROSCOPY [PDF]
, 2021 A growing biopharmaceutical market increases the importance of therapeutic proteins, of which monoclonal antibodies (mAb) are the largest category. Protein aggregation in biopharmaceutical production has important consequences in mAb immunogenicity ...
Wong, Nathan A
core +1 more source
Aggregate, 2023 Aberrant protein aggregation leads to various human diseases, but little is known about the physical chemical properties of these aggregated proteins in cells. Herein, we developed a boron‐dipyrromethene (BODIPY)‐based HaloTag probe, whose conjugation to
Baoxing Shen +7 more
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source