Results 51 to 60 of about 486,105 (348)
Zoom in on Antibody Aggregates: A Potential Pitfall in the Search of Rare EV Populations
Biomedicines, 2021 High-resolution flow cytometers (hFCM) are used for the detection of extracellular vesicles (EV) in various biological fluids. Due to the increased sensitivity of hFCM, new artifacts with the potential of interfering with data interpretation are ...
Rikke W. Rasmussen +5 more
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PLoS ONE, 2014 Prolonged elevations of plasma aldosterone levels are associated with renal pathogenesis. We hypothesized that renal distress could be imposed by an augmented aldosterone-induced protein turnover challenging cellular protein degradation systems of the ...
Muhammad Umar Cheema +6 more
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Frontiers in Cell and Developmental Biology, 2022 A major recent advance in cell biology is the mechanistic and kinetic understanding of biogenesis of many membrane-less condensates. As membrane-less condensates and membrane-bound organelles are two major approaches used by the eukaryotic cells to ...
Chuankai Zhou, Chuankai Zhou
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Influence of pH and sequence in peptide aggregation via molecular simulation [PDF]
, 2015 We employ a recently developed coarse-grained model for peptides and proteins where the effect of pH is automatically included. We explore the effect of pH in the aggregation process of the amyloidogenic peptide KTVIIE and two related sequences, using ...
Enciso, Marta +2 more
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Pathogenic polyglutamine tracts are potent inducers of spontaneous Sup35 and Rnq1 amyloidogenesis. [PDF]
PLoS ONE, 2010 The glutamine/asparagine (Q/N)-rich yeast prion protein Sup35 has a low intrinsic propensity to spontaneously self-assemble into ordered, beta-sheet-rich amyloid fibrils.
Heike Goehler +5 more
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Gene Erosion Can Lead to Gain-of-Function Alleles That Contribute to Bacterial Fitness
mBio, 2021 Despite our extensive knowledge of the genetic regulation of heat shock proteins (HSPs), the evolutionary routes that allow bacteria to adaptively tune their HSP levels and corresponding proteostatic robustness have been explored less.
Julien Mortier +10 more
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Exploring the mechanism of formation of native-like and precursor amyloid oligomers for the native acylphosphatase from Sulfolobus solfataricus [PDF]
, 2006 Over 40 human diseases are associated with the formation of well-defined proteinaceous fibrillar aggregates. Since the oligomers precursors to the fibrils are increasingly recognized to be the causative agents of such diseases, it is important to ...
BEMPORAD F +5 more
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Elastic networks of protein particles [PDF]
This paper describes the formation and properties of protein particle suspensions. The protein particles were prepared by a versatile method based on quenching a phase-separating protein–polysaccharide mixture.
Goot, A.J., van der +3 more
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A method to rapidly create protein aggregates in living cells [PDF]
, 2016 The accumulation of protein aggregates is a common pathological hallmark of many neurodegenerative diseases. However, we do not fully understand how aggregates are formed or the complex network of chaperones, proteasomes and other regulatory factors ...
Chen, L-C +7 more
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Protein aggregation. Studies of larger aggregates of C-phycocyanin [PDF]
Biochemical Journal, 1968 Aggregates of phycocyanin sedimenting at 17s, 22s and 27s are demonstrated to constitute more than 40% of crude blue–green-algal extracts, pH6·0 and I0·1, and are retained in highly purified preparations. Sedimentation-velocity studies of the large aggregates as a function of pH are reported. Sucrose-density-gradient experiments performed as a function
J J, Lee, D S, Berns
openaire +2 more sources