Results 31 to 40 of about 486,105 (348)
Membranes, 2023 The aim of this paper was to determine the emulsification properties of protein aggregates obtained from heat pretreated yellow field pea protein concentrate (PPC).
Nancy D. Asen, Rotimi E. Aluko
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The aggregation of cytochrome C may be linked to its flexibility during refolding [PDF]
, 2016 Large-scale expression of biopharmaceutical proteins in cellular hosts results in production of large insoluble mass aggregates. In order to generate functional product, these aggregates require further processing through refolding with denaturant, a ...
A Basu +19 more
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Mutational probing of protein aggregates to design aggregation‐resistant proteins [PDF]
FEBS Open Bio, 2016 Characterization of amorphous protein aggregates may offer insights into the process of aggregation. Eleven single amino acid mutants of lipase (LipA of Bacillus subtilis) were subjected to temperature‐induced aggregation, and the resultant aggregates were characterized for recovery of activity in the presence of guanidinium chloride (GdmCl).
Mohamad Zahid Kamal +4 more
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Highly Sensitive Naphthalene-Based Twisted Intramolecular Charge Transfer Molecules for the Detection of In Vitro and In Cellulo Protein Aggregates. [PDF]
ACS Med Chem LettDebnath J, Sekar Y, Bera A.
europepmc +3 more sources
Protein aggregates in Huntington's disease [PDF]
Experimental Neurology, 2012 Huntington's disease (HD) is an incurable neurodegenerative disease characterized by abnormal motor movements, personality changes, and early death. HD is caused by a mutation in the IT-15 gene that expands abnormally the number of CAG nucleotide repeats.
Arrasate, Montserrat, Finkbeiner, Steven
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Spatial control of irreversible protein aggregation [PDF]
, 2018 Liquid cellular compartments spatially segregate from the cytoplasm and can regulate aberrant protein aggregation, a process linked to several medical conditions, including Alzheimer's and Parkinson's diseases.
Mahadevan, L. +2 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background Mutations in αB‐crystallin result in proteotoxic cardiomyopathy with desmin mislocalization to protein aggregates. Intermittent fasting (IF) is a novel approach to activate transcription factor EB (TFEB), a master regulator of the autophagy ...
Xiucui Ma +12 more
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Frontiers in Physiology, 2021 The mitochondria of the proximal tubule are essential for providing energy in this nephron segment, whose ATP generation is almost exclusively oxygen dependent.
Anna-Lena Forst +3 more
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Imaging Protein Misfolding in the Brain Using β-Sheet Ligands
Frontiers in Neuroscience, 2018 Neurodegenerative diseases characterized by pathological protein accumulation in cells are termed “proteinopathies.” Although various protein aggregates share cross-β-sheet structures, actual conformations vary among each type of protein deposit.
Ryuichi Harada +4 more
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Cells, 2023 Amyotrophic lateral sclerosis (ALS) is a multi-systemic, incurable, amyloid disease affecting the motor neurons, resulting in the death of patients. The disease is either sporadic or familial with SOD1, C9orf72, FUS, and TDP-43 constituting the majority ...
Saiswaroop Rajaratnam +16 more
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