Results 11 to 20 of about 486,105 (348)

[PRION⁺] States Are Associated with Specific Histone H3 Post-Translational Modification Changes

Pathogens, 2022
Prions are proteins able to take on alternative conformations and propagate them in a self-templating process. In Saccharomyces cerevisiae, prions enable heritable responses to environmental conditions through bet-hedging mechanisms.
Samantha N. Cobos, Chaim Janani, Gabriel Cruz, Navin Rana, Elizaveta Son, Rania Frederic, Jailene Paredes Casado, Maliha Khan, Seth A. Bennett, Mariana P. Torrente   +9 more
doaj   +1 more source

Changes in Protein Non-Covalent Bonds and Aggregate Size during Dough Formation

Foods, 2020
This research investigated changes in the amounts and sizes of monomeric proteins and protein aggregates during dough mixing, with a focus on the contribution of non-covalent bonds in the aggregation of gluten proteins.
Sonoo Iwaki, Shiro Aono, Katsuyuki Hayakawa, Bin Xiao Fu, Chikako Otobe   +4 more
doaj   +1 more source

Peroxisomal Proteostasis Involves a Lon Family Protein That Functions as Protease and Chaperone [PDF]

, 2012
Proteins are subject to continuous quality control for optimal proteostasis. The knowledge of peroxisome quality control systems is still in its infancy. Here we show that peroxisomes contain a member of the Lon family of proteases (Pln).
Aksam, Antonenkov, Arnold, Bartoszewska, Bender, Bota, Buchner, Dobson, Ellis, Fraaije, Franke, Goldberg, Guinier, Hanson, Hartl, Hillenga, Islinger, Iyer, Jaenicke, Jahn, Kiel, Kiel, Kikuchi, Kozin, Lee, Lingard, Liu, Meijer, Nettleship, Nijland, Okumoto, Omi, Opaliński, Paraszkiewicz, Petoukhov, Petoukhov, Petoukhov, Powers, Quiocho, Reeder, Rep, Roessle, Roudiak, Sambrook, Sauer, Stahlberg, Steinberg, Svergun, Tyedmers, van Dijken, van Roermund, Venkatesh, Volkov, von Janowsky, Wagner, Walton, Wanders, Waterham, West   +58 more
core   +7 more sources

Amyloids and protein aggregation

Chemical Science, 2023
Sara Linse and Tuomas Knowles introduce the Chemical Science themed collection on the topic of amyloids and protein aggregation.
Sara Linse, Tuomas Knowles
openaire   +2 more sources

Two-Step Size-Exclusion Nanofiltration of Prothrombin Complex Concentrate Using Nanocellulose-Based Filter Paper

Biomedicines, 2020
Coagulation Factor IX-rich protrhombin complex concentrate (FIX-PCC) is a therapeutic biologic product that consists of a mixture of several human plasma-derived proteins, useful for treating hemophilia B. Due to its complex composition, FIX-PCC is very
Levon Manukyan, Athanasios Mantas, Mikhail Razumikhin, Andrey Katalevsky, Eugen Golubev, Albert Mihranyan   +5 more
doaj   +1 more source

Impact of Cardiovascular Diseases on Ischemic Stroke Outcomes

Journal of Integrative Neuroscience, 2022
Stroke induces complex pathological cascades in the affected brain area, leading to brain injury and functional disability. To fight against cerebral ischemia/reperfusion-induced neuronal death, numerous neuroprotective strategies and reagents have been ...
Christa C. Huber, Xuejun Wang, Hongmin Wang   +2 more
doaj   +1 more source

Inhibition of Protein Aggregation and Endoplasmic Reticulum Stress as a Targeted Therapy for α-Synucleinopathy

Pharmaceutics, 2023
α-synuclein (α-syn) is an intrinsically disordered protein abundant in the central nervous system. Physiologically, the protein regulates vesicle trafficking and neurotransmitter release in the presynaptic terminals. Pathologies related to misfolding and
Natalia Siwecka, Kamil Saramowicz, Grzegorz Galita, Wioletta Rozpędek-Kamińska, Ireneusz Majsterek   +4 more
doaj   +1 more source

Protein aggregation in bacteria [PDF]

FEMS Microbiology Reviews, 2019
ABSTRACTProtein aggregation occurs as a consequence of perturbations in protein homeostasis that can be triggered by environmental and cellular stresses. The accumulation of protein aggregates has been associated with aging and other pathologies in eukaryotes, and in bacteria with changes in growth rate, stress resistance and virulence.
Frederic D Schramm, Kristen Schroeder, Kristina Jonas   +2 more
openaire   +3 more sources

Cell-to-cell transmission of p53 aggregates: a novel player in oncology?

Molecular & Cellular Oncology, 2021
The mutants of the tumor suppressor protein p53 form protein aggregates. It has been proposed that these aggregates propagate like prions, albeit the detailed mechanism of the propagation is unclear.
Naoyuki Iwahashi, Midori Ikezaki, Hiroyuki Saito, Kenji Uchimura, Kazuchika Nishitsuji   +4 more
doaj   +1 more source

Interaction between Astaxanthin and Whey Protein Based on Fluorescence and Ultraviolet Spectroscopy

Shipin gongye ke-ji, 2022
The molecule self-assembly technology was used to prepare astaxanthin/whey protein nanocomplex, and the interaction mechanism between astaxanthin (AST) and whey protein was studied.
Yingyuan ZHAO, Shengmeng ZHANG, Yifan LI, Jin LIANG, Huihui JIA, Ziwei LI, Junxia LIU, Ruifang LI   +7 more
doaj   +1 more source