Results 11 to 20 of about 287,910 (304)

Protein Aggregates and Aggrephagy in Myopathies. [PDF]

Int J Mol Sci, 2023
A number of muscular disorders are hallmarked by the aggregation of misfolded proteins within muscle fibers. A specialized form of macroautophagy, termed aggrephagy, is designated to remove and degrade protein aggregates.
Gibertini S, Ruggieri A, Cheli M, Maggi L.   +3 more
europepmc   +2 more sources

Clearance of protein aggregates during cell division. [PDF]

Elife
Protein aggregates are spatially organized and regulated in cells to prevent the deleterious effects of proteostatic stress. Misfolding of proteins in the endoplasmic reticulum (ER) results in aggregate formation, but how the aggregates are processed ...
Du S, Wang Y, Chen B, Xie S, Chan KY, Hay DC, Chew TG.   +6 more
europepmc   +3 more sources

The deubiquitinase USP5 prevents accumulation of protein aggregates in cardiomyocytes. [PDF]

Sci Adv
Protein homeostasis is crucial for maintaining cardiomyocyte (CM) function. Disruption of proteostasis results in accumulation of protein aggregates causing cardiac pathologies such as hypertrophy, dilated cardiomyopathy (DCM), and heart failure.
Eibach Y, Kreher S, Poetsch MS, Kho AL, Gaertner U, Clemen CS, Schröder R, Guo K, Milting H, Meder B, Potente M, Richter M, Schneider A, Meiners S, Gautel M, Braun T.   +15 more
europepmc   +3 more sources

Two-Step Size-Exclusion Nanofiltration of Prothrombin Complex Concentrate Using Nanocellulose-Based Filter Paper

Biomedicines, 2020
Coagulation Factor IX-rich protrhombin complex concentrate (FIX-PCC) is a therapeutic biologic product that consists of a mixture of several human plasma-derived proteins, useful for treating hemophilia B. Due to its complex composition, FIX-PCC is very
Levon Manukyan, Athanasios Mantas, Mikhail Razumikhin, Andrey Katalevsky, Eugen Golubev, Albert Mihranyan   +5 more
doaj   +1 more source

Impact of Cardiovascular Diseases on Ischemic Stroke Outcomes

Journal of Integrative Neuroscience, 2022
Stroke induces complex pathological cascades in the affected brain area, leading to brain injury and functional disability. To fight against cerebral ischemia/reperfusion-induced neuronal death, numerous neuroprotective strategies and reagents have been ...
Christa C. Huber, Xuejun Wang, Hongmin Wang   +2 more
doaj   +1 more source

Inhibition of Protein Aggregation and Endoplasmic Reticulum Stress as a Targeted Therapy for α-Synucleinopathy

Pharmaceutics, 2023
α-synuclein (α-syn) is an intrinsically disordered protein abundant in the central nervous system. Physiologically, the protein regulates vesicle trafficking and neurotransmitter release in the presynaptic terminals. Pathologies related to misfolding and
Natalia Siwecka, Kamil Saramowicz, Grzegorz Galita, Wioletta Rozpędek-Kamińska, Ireneusz Majsterek   +4 more
doaj   +1 more source

Protein aggregation in bacteria [PDF]

FEMS Microbiology Reviews, 2019
ABSTRACTProtein aggregation occurs as a consequence of perturbations in protein homeostasis that can be triggered by environmental and cellular stresses. The accumulation of protein aggregates has been associated with aging and other pathologies in eukaryotes, and in bacteria with changes in growth rate, stress resistance and virulence.
Frederic D Schramm, Kristen Schroeder, Kristina Jonas   +2 more
openaire   +3 more sources

Cell-to-cell transmission of p53 aggregates: a novel player in oncology?

Molecular & Cellular Oncology, 2021
The mutants of the tumor suppressor protein p53 form protein aggregates. It has been proposed that these aggregates propagate like prions, albeit the detailed mechanism of the propagation is unclear.
Naoyuki Iwahashi, Midori Ikezaki, Hiroyuki Saito, Kenji Uchimura, Kazuchika Nishitsuji   +4 more
doaj   +1 more source

Focus on the Protein Fraction of Sports Nutrition Supplements

Molecules, 2022
Increasing awareness of balanced diet benefits is boosting the demand for high-protein food and beverages. Sports supplements are often preferred over traditional protein sources to meet the appropriate dietary intake since they are widely available on ...
Luisa Pellegrino, Johannes A. Hogenboom, Veronica Rosi, Marta Sindaco, Stefano Gerna, Paolo D’Incecco   +5 more
doaj   +1 more source

When aggregation-induced emission meets protein aggregates [PDF]

National Science Review, 2021
There is an unmet demand for research tools to monitor the multistep protein aggregation process in live cells, a process that has been associated with a growing number of human diseases. Recently, AIEgens have been developed to directly monitor the entire protein aggregation process in test tubes and live cells.
Sicheng Tang, Songtao Ye, Xin Zhang
openaire   +2 more sources