Results 41 to 50 of about 486,105 (348)

Tracking protein aggregate interactions [PDF]

Prion, 2011
Amyloid fibrils share a structural motif consisting of highly ordered β-sheets aligned perpendicular to the fibril axis ( 1, 2) . At each fibril end, β-sheets provide a template for recruiting and converting monomers ( 3) . Various amyloid fibrils often occur in the same individual, yet whether distinct protein aggregates aid or inhibit the assembly of
Nilsson, K. Peter R., Sigurdson, Christina J., Bartz, Jason C.   +2 more
openaire   +2 more sources

Impaired proteostatic mechanisms other than decreased protein synthesis limit old skeletal muscle recovery after disuse atrophy

Journal of Cachexia, Sarcopenia and Muscle, 2023
Background Skeletal muscle mass and strength diminish during periods of disuse but recover upon return to weight bearing in healthy adults but are incomplete in old muscle.
Jordan D. Fuqua, Marcus M. Lawrence, Zachary R. Hettinger, Agnieszka K. Borowik, Parker L. Brecheen, Marcelina M. Szczygiel, Claire B. Abbott, Frederick F. Peelor III, Amy L. Confides, Michael Kinter, Sue C. Bodine, Esther E. Dupont‐Versteegden, Benjamin F. Miller   +12 more
doaj   +1 more source

Molecular insights into substrate recognition and discrimination by the N-terminal domain of Lon AAA+ protease

eLife, 2021
The Lon AAA+ protease (LonA) is a ubiquitous ATP-dependent proteolytic machine, which selectively degrades damaged proteins or native proteins carrying exposed motifs (degrons).
Shiou-Ru Tzeng, Yin-Chu Tseng, Chien-Chu Lin, Chia-Ying Hsu, Shing-Jong Huang, Yi-Ting Kuo, Chung-I Chang   +6 more
doaj   +1 more source

Broad and Complex Roles of NBR1-Mediated Selective Autophagy in Plant Stress Responses

Cells, 2020
Selective autophagy is a highly regulated degradation pathway for the removal of specific damaged or unwanted cellular components and organelles such as protein aggregates.
Yan Zhang, Zhixiang Chen
doaj   +1 more source

Particle Detection and Characterization for Biopharmaceutical Applications: Current Principles of Established and Alternative Techniques

Pharmaceutics, 2020
Detection and characterization of particles in the visible and subvisible size range is critical in many fields of industrial research. Commercial particle analysis systems have proliferated over the last decade.
Julia Gross-Rother, Michaela Blech, Eduard Preis, Udo Bakowsky, Patrick Garidel   +4 more
doaj   +1 more source

Production of prone‐to‐aggregate proteins [PDF]

FEBS Letters, 2013
Expression of recombinant proteins inEscherichia coli(E. coli) remains the most popular and cost‐effective method for producing proteins in basic research and for pharmaceutical applications. Despite accumulating experience and methodologies developed over the years, production of recombinant proteins prone to aggregate inE.
Lebendiker, Mario, Danieli, Tsafi
openaire   +2 more sources

Colloidal stability of tannins: astringency, wine tasting and beyond [PDF]

, 2008
Tannin-tannin and tannin-protein interactions in water-ethanol solvent mixtures are studied in the context of red wine tasting. While tannin self-aggregation is relevant for visual aspect of wine tasting (limpidity and related colloidal phenomena ...
C Poulain, C Tribet, Cabane B Zanchi D Pascal C Vernhet A Poncet-Legrand C Konarev P Svergun D I, D I Svergun, D Zanchi, Haslam E, Hemingway R W, P Konarev, Pedersen J S, Shukla A Narayanan T Zanchi D, Zanchi D, Zanchi D Baron A Guyot S, Zanchi D Guyot S Konarev P Tribet C Baron A Svergun D I   +12 more
core   +1 more source

Buoyancy regulation and aggregate formation in Amoebobacter purpureus from Mahoney lake [PDF]

, 1992
The meromictic Mahoney Lake (British Columbia, Canada) contains an extremely dense layer of purple sulfur bacteria (Amoebobacter purpureus). The buoyant density of Amoebobacter cells grown in pure culture at saturating light intensity was significantly ...
Bar-Ness, Bar-Or, Booker, Bryant, Bührer, Caldwell, Cline, Courtney, Dahlbäck, Dietrich, Doyle, Eichler, Fattom, Hart, Hartree, Herbert, Huheey, Hutchinson, Jenkinson, Jörg Overmann, Kjelleberg, Lehninger, Marshall, Mas, Nikovskaya, Norbert Pfennig, Northcote, Northcote, Northcote, Ofek, Oliver, Oliver, Overmann, Overmann, Overmann, Parker, Pfennig, Reed, Rosenberg, Siefert, Takakuwa, Tilzer, Walsby, Walsby   +43 more
core   +1 more source

Folding and aggregation of designed proteins [PDF]

Proceedings of the National Academy of Sciences, 1998
Protein aggregation is studied by following the simultaneous folding of two designed identical 20-letter amino acid chains within the framework of a lattice model and using Monte Carlo simulations. It is found that protein aggregation is determined by elementary structures (partially folded intermediates) controlled by local contacts among some of the ...
Broglia R. A., Tiana G., Pasquali S., Roman H. E., Vigezzi E.   +4 more
openaire   +3 more sources

O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease. [PDF]

, 2015
Several aggregation-prone proteins associated with neurodegenerative diseases can be modified by O-linked N-acetyl-glucosamine (O-GlcNAc) in vivo. One of these proteins, α-synuclein, is a toxic aggregating protein associated with synucleinopathies ...
Ambroso, Mark R, Arnold, Don B, Langen, Ralf, Lewis, Yuka E, Lin, Yu Hsuan, Marotta, Nicholas P, Pratt, Matthew R, Roth, Maxwell T, Zaro, Balyn W   +8 more
core   +2 more sources