Results 11 to 20 of about 737,165 (295)

When aggregation-induced emission meets protein aggregates [PDF]

National Science Review, 2021
There is an unmet demand for research tools to monitor the multistep protein aggregation process in live cells, a process that has been associated with a growing number of human diseases. Recently, AIEgens have been developed to directly monitor the entire protein aggregation process in test tubes and live cells.
Sicheng Tang, Songtao Ye, Xin Zhang
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Protein aggregate myopathies [PDF]

Neurology India, 2005
Protein aggregate myopathies (PAM) are an emerging group of muscle diseases characterized by structural abnormalities. Protein aggregate myopathies are marked by the aggregation of intrinsic proteins within muscle fibers and fall into four major groups or conditions: (1) desmin-related myopathies (DRM) that include desminopathies, a-B ...
M C, Sharma, H H, Goebel
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Tracking protein aggregate interactions [PDF]

Prion, 2011
Amyloid fibrils share a structural motif consisting of highly ordered β-sheets aligned perpendicular to the fibril axis ( 1, 2) . At each fibril end, β-sheets provide a template for recruiting and converting monomers ( 3) . Various amyloid fibrils often occur in the same individual, yet whether distinct protein aggregates aid or inhibit the assembly of
Nilsson, K. Peter R., Sigurdson, Christina J., Bartz, Jason C.   +2 more
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Protein aggregation and bioprocessing [PDF]

The AAPS Journal, 2006
Protein aggregation is a common issue encountered during manufacture of biotherapeutics. It is possible to influence the amount of aggregate produced during the cell culture and purification process by carefully controlling the environment (eg, media components) and implementing appropriate strategies to minimize the extent of aggregation.
Mary E M, Cromwell, Eric, Hilario, Fred, Jacobson   +2 more
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Uncovering the Mechanism of Aggregation of Human Transthyretin. [PDF]

, 2015
The tetrameric thyroxine transport protein transthyretin (TTR) forms amyloid fibrils upon dissociation and monomer unfolding. The aggregation of transthyretin has been reported as the cause of the life-threatening transthyretin amyloidosis.
Cascio, Duilio, Eisenberg, David S, Jiang, Lin, Johnson, Lisa M, Liang, Wilson Y, Riek, Roland, Ruchala, Piotr, Saelices, Lorena, Sawaya, Michael R, Whitelegge, Julian   +9 more
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Aggregation of polyQ proteins is increased upon yeast aging and affected by Sir2 and Hsf1: novel quantitative biochemical and microscopic assays. [PDF]

PLoS ONE, 2012
Aging-related neurodegenerative disorders, such as Parkinson's, Alzheimer's and Huntington's diseases, are characterized by accumulation of protein aggregates in distinct neuronal cells that eventually die. In Huntington's disease, the protein huntingtin
Aviv Cohen, Liron Ross, Iftach Nachman, Shoshana Bar-Nun   +3 more
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Sequence-specific protein aggregation generates defined protein knockdowns in plants [PDF]

, 2016
Protein aggregation is determined by short (5-15 amino acids) aggregation-prone regions (APRs) of the polypeptide sequence that self-associate in a specific manner to form beta-structured inclusions.
Aesaert, Stijn, Betti, Camilla, Coutuer, Silvie, De Rycke, Riet, De Smet, Frederik, Gallardo, Rodrigo, Inzé, Dirk, Mishev, Kiril, Rombaut, Debbie, Rousseau, Frederic, Russinova, Eugenia, Schymkowitz, Joost, Van Breusegem, Frank, Van Lijsebettens, Maria, Vanhoutte, Isabelle, Vuylsteke, Marnik, Xu, Jie   +16 more
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Non-Arrhenius Protein Aggregation [PDF]

The AAPS Journal, 2013
Protein aggregation presents one of the key challenges in the development of protein biotherapeutics. It affects not only product quality but also potentially impacts safety, as protein aggregates have been shown to be linked with cytotoxicity and patient immunogenicity.
Wei, Wang, Christopher J, Roberts
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Aggregation is a Context-Dependent Constraint on Protein Evolution

Frontiers in Molecular Biosciences, 2021
Solubility is a requirement for many cellular processes. Loss of solubility and aggregation can lead to the partial or complete abrogation of protein function. Thus, understanding the relationship between protein evolution and aggregation is an important
Michele Monti, Michele Monti, Alexandros Armaos, Alexandros Armaos, Marco Fantini, Annalisa Pastore, Gian Gaetano Tartaglia, Gian Gaetano Tartaglia, Gian Gaetano Tartaglia, Gian Gaetano Tartaglia   +9 more
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Filter Retardation Assay for Detecting and Quantifying Polyglutamine Aggregates Using Caenorhabditis elegans Lysates [PDF]

, 2018
Protein aggregation is a hallmark of several neurodegenerative diseases and is associated with impaired protein homeostasis. This imbalance is caused by the loss of the protein's native conformation, which ultimately results in its aggregation or ...
Mata Cabana, Alejandro, Nollen, Ellen A. A., Seinstra, Renée I., Sin, Olga   +3 more
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