Results 11 to 20 of about 7,628,689 (242)

Spatial control of irreversible protein aggregation [PDF]

eLife, 2019
Liquid cellular compartments form in the cyto- or nucleoplasm and can regulate aberrant protein aggregation. Yet, the mechanisms by which these compartments affect protein aggregation remain unknown. Here, we combine kinetic theory of protein aggregation
Christoph Weber, Thomas Michaels, L Mahadevan   +2 more
doaj   +6 more sources

Protein aggregation in neurodegenerative diseases [PDF]

Chinese Medical Journal
. Neurodegenerative diseases constitute a group of chronic disorders characterized by the progressive loss of neurons. Major neurodegenerative conditions include Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, frontotemporal lobar ...
Jiannan Wang, Lijun Dai, Zhentao Zhang, Ting Gao   +3 more
doaj   +2 more sources

Age-Dependent Protein Aggregation Initiates Amyloid-β Aggregation [PDF]

Frontiers in Aging Neuroscience, 2017
Aging is the most important risk factor for neurodegenerative diseases associated with pathological protein aggregation such as Alzheimer’s disease.
Nicole Groh, Nicole Groh, Anika Bühler, Chaolie Huang, Ka Wan Li, Pim van Nierop, August B. Smit, Marcus Fändrich, Frank Baumann, Della C. David   +9 more
doaj   +4 more sources

Protein aggregation in bacteria [PDF]

FEMS Microbiology Reviews, 2019
ABSTRACTProtein aggregation occurs as a consequence of perturbations in protein homeostasis that can be triggered by environmental and cellular stresses. The accumulation of protein aggregates has been associated with aging and other pathologies in eukaryotes, and in bacteria with changes in growth rate, stress resistance and virulence.
Frederic D Schramm, Kristen Schroeder, Kristina Jonas   +2 more
openaire   +4 more sources

Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases. [PDF]

Neurology, 2019
The gold standard for a definitive diagnosis of Parkinson disease (PD) is the pathologic finding of aggregated α-synuclein into Lewy bodies and for Alzheimer disease (AD) aggregated amyloid into plaques and hyperphosphorylated tau into tangles.
Brundin, P, Cambi, F, Espay, AJ, Fasano, A, Fernandez, HH, Gan-Or, Z, Greenamyre, JT, Josephs, KA, Kauffman, MA, Lang, AE, Leverenz, JB, Litvan, I, Marsili, L, Mata, IF, Merola, A, Morgante, F, Perry, G, Sardi, SP, Savica, R, Schwarzschild, MA, Sherer, T, Simon, DK, Standaert, DG, Tanner, CM, Vizcarra, JA, Yamasaki, TR, Zabetian, CP   +26 more
core   +4 more sources

Plant-Based Inhibitors of Protein Aggregation [PDF]

Biomolecules
The assembly of amyloidogenic proteins and peptides into toxic oligomeric and fibrillar aggregates is closely connected to the onset and progression of more than 50 protein diseases, such as Alzheimer’s disease, Parkinson’s disease, prion disease, and ...
Olha Zhytniakivska, Tanmay Chaturvedi, Mette Hedegaard Thomsen   +2 more
doaj   +2 more sources

Targeting Protein Aggregation in ALS [PDF]

Biomolecules
Proteinopathies involve the abnormal accumulation of specific proteins. Maintaining the balance of the proteome is a finely regulated process managed by a complex network of cellular machinery responsible for protein synthesis, folding, and degradation ...
Michele Perni, Benedetta Mannini
doaj   +2 more sources

Moderate Protein Processing: Elucidation of Thermal Aggregation and Gel Quality and Regulatory Strategies for Excessive Aggregation [PDF]

Shipin Kexue, 2023
Heat treatment can induce muscle protein denaturation and aggregation and eventually the sol-gel tradition of proteins. The aggregation rate, degree, morphology and pattern can affect the quality of protein gels.
HAN Zongyuan, SHAO Junhua, PAN Yanmo, CHENG Kaixing, SUN Qinxiu, WEI Shuai, XIA Qiuyu, WANG Zefu, LIU Shucheng
doaj   +1 more source

When aggregation-induced emission meets protein aggregates [PDF]

National Science Review, 2021
There is an unmet demand for research tools to monitor the multistep protein aggregation process in live cells, a process that has been associated with a growing number of human diseases. Recently, AIEgens have been developed to directly monitor the entire protein aggregation process in test tubes and live cells.
Sicheng Tang, Songtao Ye, Xin Zhang
openaire   +2 more sources

Protein aggregate myopathies [PDF]

Neurology India, 2005
Protein aggregate myopathies (PAM) are an emerging group of muscle diseases characterized by structural abnormalities. Protein aggregate myopathies are marked by the aggregation of intrinsic proteins within muscle fibers and fall into four major groups or conditions: (1) desmin-related myopathies (DRM) that include desminopathies, a-B ...
M C, Sharma, H H, Goebel
openaire   +4 more sources