Results 91 to 100 of about 25,768,908 (251)

Interaction modulation through arrays of clustered methyl-arginine protein modifications

Life Science Alliance, 2018
Extensively modifiable arrays of clustered arginines in a large set of human proteins function as regulatory protein interaction platforms. Quantitative immunoprecipitation assays defined two distinct cumulative binding mechanisms operating across an ...
Jonathan Woodsmith, Victoria Casado-Medrano, Nouhad Benlasfer, Rebecca L Eccles, Saskia Hutten, Christian L Heine, Verena Thormann, Claudia Abou-Ajram, Oliver Rocks, Dorothee Dormann, Ulrich Stelzl   +10 more
doaj   +1 more source

Efficiency of Disease and Disease Activity Diagnosis Models of Systemic Lupus Erythematosus Based on Protein Array Analysis. [PDF]

J Immunol Res, 2022
Zhao Y, Qi Y, Liu X, Cui Y, Zhao Z.
europepmc   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

From research to clinical application multi-parameter testing: Marker panels for the early detection of complex diseases [PDF]

Journal of Medical Biochemistry, 2009
Multi Parameter Analysis can open novel diagnostic opportunities for the early diagnosis and screening of multimodal diseases like cancer. Single proteins have so far failed to describe such complex diseases.
Wild Norbert, Karl Johann, Risse Bernhard   +2 more
doaj  

Novel computational analysis of protein binding array data identifies direct targets of Nkx2.2 in the pancreas

BMC Bioinformatics, 2011
Background The creation of a complete genome-wide map of transcription factor binding sites is essential for understanding gene regulatory networks in vivo.
Kaestner Klaus H, Mastracci Teresa L, Anderson Keith R, Hill Jonathon T, Sussel Lori   +4 more
doaj   +1 more source

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source

An investigation of a frequency diverse array [PDF]

, 2009
This thesis presents a novel concept for focusing an antenna beam pattern as a function of range, time, and angle. In conventional phased arrays, beam steering is achieved by applying a linear phase progression across the aperture.
Antonik, P.
core  

A Label-Free Fluorescent Array Sensor Utilizing Liposome Encapsulating Calcein for Discriminating Target Proteins by Principal Component Analysis

Sensors, 2017
A new fluorescent arrayed biosensor has been developed to discriminate species and concentrations of target proteins by using plural different phospholipid liposome species encapsulating fluorescent molecules, utilizing differences in permeation of the ...
Ryota Imamura, Naoki Murata, Toshinori Shimanouchi, Kaoru Yamashita, Masayuki Fukuzawa, Minoru Noda   +5 more
doaj   +1 more source

Evaluation of Dried Plasma Spot‐Based Quantification of Glial Fibrillary Acidic Protein as a Disease‐Associated Biomarker in Neuromyelitis Optica Spectrum Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the diagnostic accuracy of glial fibrillary acidic protein (GFAP) measured in dried plasma spots versus conventional plasma‐ and serum‐GFAP testing for assessment of disease severity in aquaporin‐4 immunoglobulin G–positive neuromyelitis optica spectrum disorder (AQP4‐IgG+ NMOSD).
Felix Wohlrab, Evelyn Alvarez, Roua Hamdi, Bingqing Zhang, Hayeun Ji, Niyati Jhaveri, Patrick Schindler, Pedro Sanchez, Pia S. Sperber, Tanja Schmitz‐Hübsch, Frederike C. Oertel, Nisa Vorasoot, Najib Kissani, Falko Böhringer, Jens Kuhle, Anne‐Katrin Pröbstel, Xiao‐Jun Ma, Péter Körtvelyessy, Patrick Waters, Friedemann Paul   +19 more
wiley   +1 more source

Structural analysis of Salmonella enterica effector protein SopD [PDF]

, 2004
Salmonella outer protein D (SopD) is a type III secreted virulence effector protein from Salmonella enterica. Full-length SopD and SopD lacking 16 amino acids at the N-terminus (SopDDeltaN) have been expressed as fusions with GST in Escherichia coli ...
Williams, C, Gill, A C, Galyov, E E, van den Elsen, J M H, Upadhyay, A, Bagby, S, Wood, M W, Philippe, D L   +7 more
core   +1 more source