Results 121 to 130 of about 2,270,992 (356)

Transcriptional activation of CBFβ by CDK11p110 is necessary to promote osteosarcoma cell proliferation. [PDF]

, 2019
BACKGROUND:Aberrant expression of cyclin-dependent protein kinases (CDK) is a hallmark of cancer. CDK11 plays a crucial role in cancer cell growth and proliferation.
Duan, Zhenfeng, Feng, Yong, Hornicek, Francis, Liao, Yunfei, Shao, Zengwu, Shen, Jacson, Zhang, Jianming   +6 more
core   +1 more source

Neurofibromin knockdown in glioma cell lines is associated with changes in cytokine and chemokine secretion in vitro. [PDF]

, 2018
The neurofibromin-1 tumor suppressor gene (NF1) is altered in approximately 20% of sporadic glioblastoma (GBM) cases. NF1 deficient GBM frequently shows a mesenchymal gene expression signature, suggesting a relationship between NF1 status and the tumor ...
Mukherjee, Joydeep, Pieper, Russell O, Wood, Matthew D   +2 more
core   +3 more sources

A bead-based western for high-throughput cellular signal transduction analyses

Nature Communications, 2016
Dissecting cellular signalling requires the analysis of large numbers of proteins. Here the authors describe DigiWest, a high-throughput protein detection method that combines the concept of western and widely-used bead array systems that allows rapid ...
Fridolin Treindl, Benjamin Ruprecht, Yvonne Beiter, Silke Schultz, Anette Döttinger, Annette Staebler, Thomas O. Joos, Simon Kling, Oliver Poetz, Tanja Fehm, Hans Neubauer, Bernhard Kuster, Markus F. Templin   +12 more
doaj   +1 more source

CXCL1 as an Unfavorable Prognosis Factor Negatively Regulated by DACH1 in Non-small Cell Lung Cancer

Frontiers in Oncology, 2020
Background: Interaction between cancer cells with microenvironment is essential for cancer progression, therapeutic resistance and prognosis. Chemokine CXCL1 shows variable roles in the development of cancers.
Shengnan Yu, Ming Yi, Linping Xu, Shuang Qin, Anping Li, Kongming Wu, Kongming Wu   +6 more
doaj   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Chemoenzymatic Probes for Detecting and Imaging Fucose-α(1-2)-galactose Glycan Biomarkers [PDF]

, 2012
The disaccharide motif fucose-α(1-2)-galactose (Fucα(1-2)Gal) is involved in many important physiological processes, such as learning and memory, inflammation, asthma, and tumorigenesis.
Becker D. J., Blixt O., Blixt O., Chang C.-F., Chang W.-W., Chithra Krishnamurthy, Clark P. M., David F. Smith, Delves P. J., Hanson S. R., Jean-Luc Chaubard, Khidekel N., Kim Y., Laughlin S. T., Lee J. S., Linda C. Hsieh-Wilson, Manimala J. C., Manimala J. C., Miyake M., Murrey H. E., Murrey H. E., Peracaula R., Pohle W., Rexach J. E., Schröder F. H., Tanaka Y., Tiunova A. A., Wen Yi, Yi W., Zhang S., Zheng T.   +30 more
core   +3 more sources

BiFCROS: A Low-Background Fluorescence Repressor Operator System for Labeling of Genomic Loci

G3: Genes, Genomes, Genetics, 2017
Fluorescence-based methods are widely used to analyze elementary cell processes such as DNA replication or chromosomal folding and segregation. Labeling DNA with a fluorescent protein allows the visualization of its temporal and spatial organization. One
Sarah Milbredt, Torsten Waldminghaus
doaj   +1 more source

Exploration and Analysis of DNA Microarray and Protein Array Data

Wiley Series in Probability and Statistics, 2003
Preface.1 A Brief Introduction.1.1 A Note on Exploratory Data Analysis.1.2 Computing Considerations and Software.1.3 A Brief Outline of the Book.2 Genomics Basics.2.1 Genes.2.2 DNA.2.3 Gene Expression.2.4 Hybridization Assays and Other Laboratory ...
D. Amaratunga, Javier Cabrera
semanticscholar   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

YPIBP: A repository for phosphoinositide-binding proteins in yeast

Computational and Structural Biotechnology Journal, 2021
Phosphoinositides (PIs) are a family of eight lipids consisting of phosphatidylinositol (PtdIns) and its seven phosphorylated forms. PIs have important regulatory functions in the cell including lipid signaling, protein transport, and membrane ...
Jagat Rathod, Han-Chen Yen, Biqing Liang, Yan-Yuan Tseng, Chien-Sheng Chen, Wei-Sheng Wu   +5 more
doaj