Results 231 to 240 of about 559,282 (295)

The PI3K pathway is a downstream effector of NRF2 activation in the esophagus. [PDF]

Transl Oncol
Subramaniyan B, Li Y, Xiong Z, Paiboonrungruang C, Bui-Linh C, Spitz F, Chen X.   +6 more
europepmc   +1 more source

Design, Fabrication and Functional Analysis of a New Protein Array Based on ssDNA-based Assembly

, 2006
Parayil Kumaran Ajikumar, Jin Kiat Ng, Yew Chung Tang, Jim Yang Lee, Gregory Stephanopoulos, Heng‐Phon Too   +5 more
openalex   +1 more source

Machine Learning‐Informed Nano Co‐Assembly Inhibits Fibroblast Activation Protein and Improves Drug Delivery in Fibrotic Tissue

Advanced Materials, EarlyView.
We present SP‐13786 (SP), a fibroblast activation protein (FAP) inhibitor, as a universal excipient for co‐assembling stable drug nanoparticles (SCAN). Assembly mechanism deciphered by molecular dynamics and explainable machine learning, SCAN attenuate fibrosis‐induced stromal barriers, enhances lesional drug accumulation, and improves therapeutic ...
Zehua Liu, Qiang Long, Yihao Liu, Xiuqiao Sun, Baoding Zhang, Binxin Liao, Weibin Wu, Wangxi Hai, Pei Zhang, Wenhua Lian, Yuewen Zhu, Zheng Wang, Caisheng Wu, Xianming Deng, Hélder A. Santos, Xiaofeng Ye   +15 more
wiley   +1 more source

Identifying Pathoadaptation in Pseudomonas aeruginosa Using Glycopolymer Sensor Arrays. [PDF]

ACS Sens
Johnson C, Leslie KG, Franco Ortega S, Moir JWB, Girkin JM, Johansen HK, Friman VP, Mahon CS.   +7 more
europepmc   +1 more source

Poking Pluripotency: Nanoinjection Into Human iPSCs

Advanced Materials, EarlyView.
Nanoinjection into hiPSCs: silicon nanotubes effectively transfect human induced pluripotent stem cells (hiPSCs) with mRNA, enabled by a delayed extracellular matrix application and enhanced surface functionalization. Nanoinjection is demonstrated with several reporter mRNA, including co‐transfection of mCherry and GFP.
Jann Harberts, Vuong Thi Thanh Xuan Ho, Yuqi Yang, Yuan Jiang, Roey Elnathan, Nicolas H. Voelcker   +5 more
wiley   +1 more source

Parkinson's disease-associated alterations in DNA methylation and hydroxymethylation in human brain. [PDF]

NPJ Parkinsons Dis
Choza JI, Virani M, Kuhn NC, Adams M, Kochmanski J, Bernstein AI.   +5 more
europepmc   +1 more source

Piezoelectric Stimulation of Neural Cells: Exploring the Synergistic Potential of Hybrid Scaffolds for Enhanced Regeneration

Advanced Materials Interfaces, EarlyView.
Hybrid piezoelectric scaffolds offer a promising route for Central Nervous System regeneration by combining structural and electrical cues to support neural stem cell growth. This review highlights their potential to overcome current challenges in neural tissue engineering by exploring porous hybrid materials, their biological interactions, and ...
Heather F. Titterton, Chris R. Bowen, Hamideh Khanbareh   +2 more
wiley   +1 more source

Human O-GlcNAcase catalytic-stalk dimer anchors flexible histone binding domains. [PDF]

Commun Chem
Nyenhuis SB, Steenackers A, Mukherjee MM, Hinshaw JE, Hanover JA.   +4 more
europepmc   +1 more source

Study of a Novel Bi‐Layered Thermoplastic Polyurethane Patch for Congenital Diaphragmatic Hernia

Advanced Materials Interfaces, EarlyView.
Large congenital diaphragmatic hernia remains a challenge due to the poor compatibility of current prostheses. To tackle this problem, a bilayer thermoplastic polyurethane patch with tunable mechanical properties is engineered, whose fibrous side supports rapid fibroblast and myoblast colonization, while the smooth film limits adhesions.
Guillaume Leks, Julie Favre, Manon Zislin, Rodolphe Migneret, Jordana Hirtzel, Vincent Ball, Cendrine Seguin, Anne Hebraud, Emeline Lobry, Guy Schlatter, Nadia Bahlouli, Hamdi Jmal, Benoît Frisch, Sylvie Fournel, Isabelle Talon   +14 more
wiley   +1 more source