Results 81 to 90 of about 2,270,992 (356)

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

Molecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens, Anouk Mentink, Frank A. W. Coumans, Eshwari Dathathri, Khrystany T. Isebia, Jaco Kraan, Ronald de Wit, John W. M. Martens, Leon W. M. M. Terstappen   +8 more
wiley   +1 more source

Identification of Melatonin-Regulated Genes in the Ovine Pituitary Pars Tuberalis, a Target Site for Seasonal Hormone Control [PDF]

, 2008
The pars tuberalis (PT) of the pituitary gland expresses a high density of melatonin (MEL) receptors and is believed to regulate seasonal physiology by decoding changes in nocturnal melatonin secretion.
Alison Downing, Ando, Andrew S. I. Loudon, Ashburner, Bae, Barrett, Bartness, Bechtold, Benoit Malpaux, Bockers, Bockers, Bockmann, Brahimi-Horn, Camon, Carr, Chemineau, Chen, Curlewis, Daphne Mouzaki, Dardente, Dave W. Burt, David Waddington, Draghici, Dupre, Fukuhara, Gerald A. Lincoln, Ghorbel, Graham, Grossmann, Hanon, Hazlerigg, Hazlerigg, Hazlerigg, Hogenesch, Hu, Hu, Johnston, Johnston, Johnston, Julian R. E. Davis, Kel, Kijas, Klosen, Ko, Lamolet, Lee, Lincoln, Lincoln, Lincoln, Lincoln, Malpaux, Merks, Messager, Michan, Morgan, Morgan, Mutoh, Nakao, Naya, Naya, Nilaweera, Oki, Poulin, Reick, Revollo, Richard Talbot, Roepke, Rutter, Samal, Sandrine M. Dupré, Schroeder, Segawa, Stehle, Stirland, Storey, Su, Tobler, Tournier, Wagner, Westfall, Williams, Wittkowski, Yang, Yokoyama   +83 more
core   +2 more sources

Single-Cell Spatial MIST for Versatile, Scalable Detection of Protein Markers

Biosensors, 2023
High-multiplex detection of protein biomarkers across tissue regions has been an attractive spatial biology approach due to significant advantages over traditional immunohistochemistry (IHC) methods. Different from most methods, spatial multiplex in situ
Arafat Meah, Vadanasundari Vedarethinam, Robert Bronstein, Nehaben Gujarati, Tanya Jain, Sandeep K. Mallipattu, Yueming Li, Jun Wang   +7 more
doaj   +1 more source

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source

The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. [PDF]

, 2014
Unlike the other MAP3Ks, MEKK1 (encoded by Map3k1) contains a PHD motif. To understand the role of this motif, we have created a knockin mutant of mouse Map3k1 (Map3k1(m) (PHD)) with an inactive PHD motif.
Anwar, Saba, Charlaftis, Nikolaos, Gallagher, Ewen, Karin, Michael, Suddason, Tesha, Wu, Xuefeng   +5 more
core   +2 more sources

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

Affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria [PDF]

, 2014
Systemic inflammation and sequestration of parasitized erythrocytes are central processes in the pathophysiology of severe Plasmodium falciparum childhood malaria. However, it is still not understood why some children are more at risks to develop malaria
Afolabi, Nathaniel K., Ajetunmobi, Wasiu A., Akinbami, Felix O., Akinkunmi, Francis, Bachmann, Julie, Brown, Biobele J., Burte, Florence, Conte, Ianina, Fernandez-Reyes, Delmiro, Kampf, Caroline, Nilsson, Peter, Omokhodion, Samuel, Orimadegun, Adebola E., Pawitan, Yudi, Pramana, Setia, Schwenk, Jochen M., Shokunbi, Wuraola A., Sodeinde, Olugbemiro, Uhlen, Mathias, Wahlgren, Mats   +19 more
core   +3 more sources

Identification of proteins associated with clinical and pathological features of proliferative diabetic retinopathy in vitreous and fibrovascular membranes. [PDF]

PLoS ONE, 2017
To identify the protein profiles in vitreous associated with retinal fibrosis, angiogenesis, and neurite formation in epiretinal fibrovascular membranes (FVMs) in patients with proliferative diabetic retinopathy (PDR).Vitreous samples of 5 non-diabetic ...
Ingeborg Klaassen, Ewout W de Vries, Ilse M C Vogels, Antoine H C van Kampen, Machteld I Bosscha, David H W Steel, Cornelis J F Van Noorden, Sarit Y Lesnik-Oberstein, Reinier O Schlingemann   +8 more
doaj   +1 more source

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

KIAA0101 (OEACT-1), an expressionally down-regulated and growth-inhibitory gene in human hepatocellular carcinoma

BMC Cancer, 2006
Background Our previous cDNA array results indicated KIAA0101 as one of the differentially expressed genes in human hepatocellular carcinoma (HCC) as compared with non-cancerous liver.
Li Jinjun, Guo Minglei, Wan Dafang, Gu Jianren   +3 more
doaj   +1 more source