Results 51 to 60 of about 25,791,466 (309)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Zinc Modulates the Interaction of Protein C and Activated Protein C with Endothelial Cell Protein C Receptor [PDF]

Journal of Biological Chemistry, 2010
Zinc is an essential trace element for human nutrition and is critical to the structure, stability, and function of many proteins. Zinc ions were shown to enhance activation of the intrinsic pathway of coagulation but down-regulate the extrinsic pathway of coagulation. The protein C pathway plays a key role in blood coagulation and inflammation.
Prosenjit, Sen, Sanghamitra, Sahoo, Usha R, Pendurthi, L Vijaya Mohan, Rao   +3 more
openaire   +2 more sources

A script to highlight hydrophobicity and charge on protein surfaces [PDF]

, 2015
The composition of protein surfaces determines both affinity and specificity of protein-protein interactions. Matching of hydrophobic contacts and charged groups on both sites of the interface are crucial to ensure specificity.
Tania eMorán Luengo, Stefan G. D. Rüdiger, Dominique Hagemans, Cellular Protein Chemistry, Ianthe A. E. M. van Belzen, Ianthe A.E.M. van Belzen, van Belzen, Ianthe A E M, Sub Cellular Protein Chemistry, Morán Luengo, Tania, Rüdiger, Stefan G D, Tania Morán Luengo, Dominique eHagemans, Hagemans, Dominique   +12 more
core   +2 more sources

The 89,000-Mr murine cytomegalovirus immediate-early protein stimulates c-fos expression and cellular DNA synthesis [PDF]

, 1988
The immediate-early (IE) genes of murine cytomegalovirus (MCMV) are expressed in the absence of prior viral protein synthesis and regulate the transcription of MCMV early genes. The effect of MCMV IE genes on growth induction was studied.
Philipson, L., Pepperkok, Rainer, Koszinowski, Ulrich H., Schickedanz, Jörg, Schickedanz, J., Klein, R., Klein, Rüdiger, Philipson, Lennart, Ansorge, Wilhelm, Koszinowski, U., Ansorge, W., Pepperkok, R.   +11 more
core   +2 more sources

Coagulation Parameters in Post-Covid-19 Condition in Relation to Various Titers of Anti-SARS-CoV-2 IgG in Blood Plasma

International Journal of General Medicine, 2023
Kateryna Strubchevska,1 Antonina Rachkovska,2 Daryna Krenytska,2 Vitalii Karbovskyy,3 Marko Kozyk,1 Benjamin Secor,4 Nataliia Raksha,2 Tetiana Vovk,2 Olexii Savchuk,2 Tetyana Falalyeyeva,2 Rostyslav Kaminsky,5 Liudmyla Ostapchenko2 1Department of ...
Strubchevska K, Rachkovska A, Krenytska D, Karbovskyy V, Kozyk M, Secor B, Raksha N, Vovk T, Savchuk O, Falalyeyeva T, Kaminsky R, Ostapchenko L   +11 more
doaj  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Cbl-associated protein is tyrosine phosphorylated by c-Abl and c-Src kinases [PDF]

, 2009
Background: The c-Cbl-associated protein (CAP), also known as ponsin, localizes to focal adhesions and stress fibers and is involved in signaling events.
Tomasovic, Ana, Ana Tomasovic, Tikkanen Ritva, Fernow Inga, Inga Fernow, Siehoff-Icking, Ann, Fernow, Inga Susanne, Tikkanen, Ritva, Ann Siehoff-Icking, Tomasovic Ana, Siehoff-Icking Ann, Ritva Tikkanen   +11 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Proteomic and 3D structure analyses highlight the C/D box snoRNP assembly mechanism and its control [PDF]

, 2014
In vitro, assembly of box C/D small nucleolar ribonucleoproteins (snoRNPs) involves the sequential recruitment of core proteins to snoRNAs. In vivo, however, assembly factors are required (NUFIP, BCD1, and the HSP90–R2TP complex), and it is unknown ...
Franck Vandermoere, Ahmad, Yasmeen, Bertrand, Edouard, Bérengère Pradet-Balade, Leonhardt, Heinrich, Charron, Christophe, Hallais, Marie, Christophe Charron, Marie Hallais, Vandermoere, Franck, Jonathan Bizarro, Pradet-Balade, Berengere, Christiane Branlant, Yasmeen Ahmad, Chagot, Marie-Eve, Céline Verheggen, Lamond, Angus; id_orcid, Heinrich Leonhardt, Branlant, Christiane, Edouard Bertrand, Lamond, Angus, Charpentier, Bruno, Angus Lamond, Xavier Manival, Manival, Xavier, Marie-Eve Chagot, Westman, Belinda, Boulon, Severine, Belinda Westman, Séverine Boulon, Verheggen, Celine, Bruno Charpentier, Bizarro, Jonathan   +32 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source