Results 61 to 70 of about 25,791,466 (309)

C-reactive protein: associations with haematological variables, cardiovascular risk factors and prevalent cardiovascular disease [PDF]

, 2003
C-reactive protein (CRP) has been proposed as a risk factor for cardiovascular disease; however, this association is confounded by mutual relationships with both classical and haematological cardiovascular risk factors. We, therefore, measured CRP with a
Lowe, G.D.O., Rumley, A., Tunstall-Pedoe, H., Woodward, M.   +3 more
core   +1 more source

Effects of pulse-therapy on natural anticoagulant system of the endothelium in nonspecific aortoarteritis

Терапевтический архив, 2003
Aim. To investigate the influence of pulse-therapy on anticoagulant system of the endothelium in patients with nonspecific aortoarteritis. Material and methods. Eleven patients (9 females and 2 males, mean age 33.4 ± 8.8 years, the disease duration 5.8 ±
M S Guryeva, A A Baranov, S V Bagrakova, E L Nasonov, D G Zharikova   +4 more
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Interrogation of the protein-protein interactions between human BRCA2 BRC repeats and RAD51 reveals atomistic determinants of affinity [PDF]

, 2011
The breast cancer suppressor BRCA2 controls the recombinase RAD51 in the reactions that mediate homologous DNA recombination, an essential cellular process required for the error-free repair of DNA double-stranded breaks.
Rajendra, Eason, Skylaris Chris-Kriton, Cole, Daniel J., Venkitaraman Ashok R., Hardwick, Bryn, Payne, Mike C., Mike C. Payne, McKenzie, Grahame J., Grahame J. McKenzie, Cole Daniel J., Mike C Payne, Hardwick Bryn, McKenzie Grahame J., Bryn Hardwick, Grahame J McKenzie, Ashok R Venkitaraman, Chris-Kriton Skylaris, Daniel J Cole, Ashok R. Venkitaraman, Eeson Rajendra, Roberts-Thomson Meredith, Skylaris, Chris-Kriton, Payne Mike C., Kowalczykowski, Stephen Charles, Venkitaraman, Ashok R., Rajendra Eeson, Roberts-Thomson, Meredith, Daniel J. Cole, Meredith Roberts-Thomson   +28 more
core   +3 more sources

THROMBOPHILIA PROFILE IN YOUNG PATIENTS OF CEREBROVASCULAR ACCIDENT- AN INSTITUTION BASED STUDY

Pakistan Armed Forces Medical Journal, 2018
Objective: To find out frequency of different causes of thrombophilia in young patients of cerebrovascular accidents. Study Design: Cross sectional descriptive study.
Amna Khalid, Saleem Ahmed Khan, Nasir udin, Wasim Alamgir, Rabia Anwar, Rabia Anwar   +5 more
doaj  

Thrombomodulin: A key regulator of intravascular blood coagulation, fibrinolysis, and inflammation, and a treatment for disseminated intravascular coagulation

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
Thrombomodulin (TM) is an important regulator of intravascular blood coagulation, fibrinolysis, and inflammation. TM inhibits the procoagulant and proinflammatory activities of thrombin and promotes the thrombin-induced activation of protein C (PC) bound
Koji SUZUKI
doaj   +1 more source

Characterising the RNA-binding protein atlas of the mammalian brain uncovers RBM5 misregulation in mouse models of Huntington’s disease

Nature Communications, 2023
RNA-binding proteins (RBPs) are key players regulating RNA processing and are associated with disorders ranging from cancer to neurodegeneration. Here, we present a proteomics workflow for large-scale identification of RBPs and their RNA-binding regions ...
Meeli Mullari, Nicolas Fossat, Niels H. Skotte, Andrea Asenjo-Martinez, David T. Humphreys, Jens Bukh, Agnete Kirkeby, Troels K. H. Scheel, Michael L. Nielsen   +8 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Human protein C concentrate in the treatment of purpura fulminans : a retrospective analysis of safety and outcome in 94 pediatric patients [PDF]

, 2010
Introduction: Purpura fulminans (PF) is a devastating complication of uncontrolled systemic inflammation, associated with high incidence of amputations, skin grafts and death.
Doris Fischer, Bruno Eberspacher, Flora Y Wong, Veldman, Alex, Fischer, Doris, Wong, Flora Y., Rudolf Schosser, Kreuz, Wolfhart, Alex Veldman, Mansmann, Ulrich, Eberspaecher, Bruno, Schosser, Rudolf, Michael Sasse, Ulrich Mansmann, Sasse, Michael, Eberspächer, Bruno, Wolfhart Kreuz   +16 more
core   +1 more source

Activity of protein C, protein S and antithrombin 3 in COVID-19 patients treated with different modalities of oxygen supplementation

Türk Biyokimya Dergisi
COVID-19 in it is more severe form is characterized by a hyperinflammatory condition, hypercoagulation state and the appearance of pulmonary microembolism.
Ana Šavuk, Danijela Grizelj, Tomo Svaguša, Melanie-Ivana Čulo, Nikola Zagorec, Sara Šakota, Biserka Orehovec, Tomislav Kelava, Ana Livun, Ivan Marković, Josip Baković, Tatjana Kereš   +11 more
doaj   +1 more source