Results 21 to 30 of about 6,498,873 (334)

Filter Retardation Assay for Detecting and Quantifying Polyglutamine Aggregates Using Caenorhabditis elegans Lysates [PDF]

, 2018
Protein aggregation is a hallmark of several neurodegenerative diseases and is associated with impaired protein homeostasis. This imbalance is caused by the loss of the protein's native conformation, which ultimately results in its aggregation or ...
Mata Cabana, Alejandro, Nollen, Ellen A. A., Seinstra, Renée I., Sin, Olga   +3 more
core   +2 more sources

The Conformational Plasticity of Protein Kinases [PDF]

Cell, 2002
Protein kinases operate in a large number of distinct signaling pathways, where the tight regulation of their catalytic activity is crucial to the development and maintenance of eukaryotic organisms. The catalytic domains of different kinases adopt strikingly similar structures when they are active.
Morgan Huse, John Kuriyan, John Kuriyan
openaire   +3 more sources

Parsimony in Protein Conformational Change [PDF]

Structure, 2015
Protein conformational change is analyzed by finding the minimalist backbone torsion angle rotations that superpose crystal structures within experimental error. Of several approaches for enforcing parsimony during flexible least-squares superposition, an ℓ(1)-norm restraint provided greatest consistency with independent indications of flexibility from
Jack J. Skalicky, Michael Chapman, Brynmor K. Chapman, Rafael Brüschweiler, Omar Davulcu   +4 more
openaire   +3 more sources

The Crystal Structure of Monovalent Streptavidin. [PDF]

, 2016
The strong interaction between streptavidin (SA) and biotin is widely utilized in biotechnological applications. A SA variant, monovalent SA, was developed with a single and high affinity biotin-binding site within the intact tetramer.
Biswas, Sangita, Deng, Wenbin, Yu, Hongjun, Zhang, Min   +3 more
core   +1 more source

Identifying the protein folding nucleus using molecular dynamics [PDF]

, 2000
Molecular dynamics simulations of folding in an off-lattice protein model reveal a nucleation scenario, in which a few well-defined contacts are formed with high probability in the transition state ensemble of conformations.
Buldyrev, Sergey V., Dokholyan, Nikolay V., Shakhnovich, Eugene I., Stanley, Harry E.   +3 more
core   +1 more source

The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach [PDF]

, 2013
The calcitonin gene-related peptide (CGRP) receptor is a complex of a calcitonin receptor-like receptor (CLR), which is a family B G-protein-coupled receptor (GPCR) and receptor activity modifying protein 1.
Alex C. Conner, Barwell J, Bruck Taddese, Christopher A. Reynolds, Conner AC, David R. Poyner, Debbie L. Hay, Harriet A. Watkins, James Barwell, Kevin J. Smith, Michael. J. Woolley, Urano D, Watkins HA, Z. Gamze Karakullukcu   +13 more
core   +2 more sources

Conformational transition of a myelin protein [PDF]

FEBS Letters, 1971
An interesting transition from conformation to p-structure has been reported for phosvitin [ 1, 21. Taborsky [l] found that the transition from random to &structure was induced by low pH (1.8) and was reversed by raising the pH. Perlman and Grizzuti [2] found that at pH 2.0 phosvitin had a /3-structure, while in the pH range 6.0-10.0 the ORD and CD ...
John Anthony, Mario A. Moscarello
openaire   +3 more sources

Protein conformation in pure and hydrated deep eutectic solvents.

Physical Chemistry, Chemical Physics - PCCP, 2017
Deep eutectic solvents (DES) have recently been postulated as possible environments where protein structure may be preserved in the absence of water. Here we present our results towards understanding protein conformation in choline chloride-based DES and
Adrian Sanchez-Fernandez, Adrian Sanchez-Fernandez, K. Edler, T. Arnold, D. Venero, Andrew J Jackson, Andrew J Jackson   +6 more
semanticscholar   +1 more source

Conformational kinetics reveals affinities of protein conformational states [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance Despite 50 years of studies of coupled binding and conformational change reactions in proteins and nucleic acids, there has been no detailed analysis of the affinities of the multiple conformational states involved. The relationship between these affinities and the dynamics of conformational change has also been largely ...
Daniels, Kyle G, Suo, Yang, Oas, Terrence G   +2 more
openaire   +2 more sources

Mobility Measurements Probe Conformational Changes in Membrane Proteins due to Tension

, 2015
The function of membrane-embedded proteins such as ion channels depends crucially on their conformation. We demonstrate how conformational changes in asymmetric membrane proteins may be inferred from measurements of their diffusion.
Morris, Richard G., Turner, Matthew S.
core   +1 more source