Results 21 to 30 of about 6,420,371 (402)
Protein Adsorption and Conformational Changes [PDF]
Molecules, 2021 Protein adsorption onto surfaces of diverse materials of both natural and artificial origin is of utmost relevance in many areas of research and technology: medicine, pharmaceutical sciences, analytical sciences, biotechnology, nanotechnology, and cell biology, among others [...]
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Novel ADAMTS13 mutations in a patient with congenital thrombotic thrombocytopenic purpura
Hematology, 2023 Congenital thrombotic thrombocytopenic purpura (TTP) is a rare autosomal recessive genetic disorder caused by mutations in the ADAMTS13 gene. Approximately 200 mutations of the ADAMTS-13 gene have been identified, although only a few have been ...
Zhitao Wang +6 more
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Mechano-transduction: from molecules to tissues. [PDF]
, 2014 External forces play complex roles in cell organization, fate, and homeostasis. Changes in these forces, or how cells respond to them, can result in abnormal embryonic development and diseases in adults.
Dunn, Alexander R +3 more
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Biomolecules, 2019 De novo protein synthesis by the ribosome and its multitude of co-factors must occur in a tightly regulated manner to ensure that the correct proteins are produced accurately at the right time and, in some cases, also in the proper location.
Kelvin K. Hui +3 more
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Population Shuffling of Protein Conformations [PDF]
Angewandte Chemie, 2014 AbstractMotions play a vital role in the functions of many proteins. Discrete conformational transitions to excited states, happening on timescales of hundreds of microseconds, have been extensively characterized. On the other hand, the dynamics of the ground state are widely unexplored.
Claudia Schwiegk +9 more
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Aβ Secretion and Plaque Formation Depend on Autophagy
Cell Reports, 2013 Alzheimer’s disease (AD) is a neurodegenerative disease biochemically characterized by aberrant protein aggregation, including amyloid beta (Aβ) peptide accumulation. Protein aggregates in the cell are cleared by autophagy, a mechanism impaired in AD. To
Per Nilsson +9 more
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Dependence of protein-induced lipid bilayer deformations on protein shape [PDF]
, 2022 Membrane proteins typically deform the surrounding lipid bilayer membrane, which can play an important role in the function, regulation, and organization of membrane proteins. Membrane elasticity theory provides a beautiful description of protein-induced lipid bilayer deformations, in which all physical parameters can be directly determined from ...
arxiv +1 more source
Tracing conformational changes in proteins [PDF]
2009 IEEE International Conference on Bioinformatics and Biomedicine Workshop, 2009 Many proteins undergo extensive conformational changes as part of their functionality. Tracing these changes is important for understanding the way these proteins function. Traditional biophysics-based conformational search methods require a large number of calculations and are hard to apply to large-scale conformational motions.In this work we ...
Mark Moll +6 more
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Structural Changes of RNA in Complex with Proteins in the SRP
Frontiers in Molecular Biosciences, 2018 The structural flexibility of RNA allows it to exist in several shapes and sizes. Thus, RNA is functionally diverse and is known to be involved in processes such as catalysis, ligand binding, and most importantly, protein recognition.
Janine K. Flores, Sandro F. Ataide
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Cryo-EM structure of the E. coli translating ribosome in complex with SRP and its receptor [PDF]
, 2010 We report the 'early' conformation of the Escherichia coli signal recognition particle (SRP) and its receptor FtsY bound to the translating ribosome, as determined by cryo-EM.
Ban, Nenad +4 more
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