Results 211 to 220 of about 1,856,978 (353)

The proteasome and the degradation of oxidized proteins: Part I—structure of proteasomes

, 2013
Tobias Jung, Tilman Grune
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Synthetic protein degradation circuits using programmable cleavage and ligation by Sortase A. [PDF]

Nat Commun
Yang HK, Muthukumar PK, Chen W.
europepmc   +1 more source

Additional file 2 of TRIM7 suppresses transmissible gastroenteritis virus replication by targeting the degradation of N protein and activating RIG-I-mediated type I IFN antiviral response

Qin, Weiyun, Xie, Yunxiao, Liang, Haijiang, Wu, Zuolin, Yang, Songbai, Zhou, Xiaolong, Zhao, Ayong   +6 more
openalex   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Recent Advances in the Development of Pro-PROTAC for Selective Protein Degradation. [PDF]

Pharmaceutics
Hakem F, Abdelwaly A, Alshaman R, Alattar A, Alanazi FE, Zaitone SA, Helal MA.   +6 more
europepmc   +1 more source

The balance of protein expression and degradation: an ESCRTs point of view

, 2013
Markus Babst, Greg Odorizzi
openalex   +1 more source

Mechanical impact induces cartilage degradation via mitogen activated protein kinases [PDF]

, 2010
Lei Ding, Emily Heying, Neville Nicholson, Nick Stroud, Gene A. Homandberg, Joseph A. Buckwalter, Danping Guo, James A. Martin   +7 more
openalex   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Correction: Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation. [PDF]

RSC Chem Biol
Bond MJ, Crews CM.
europepmc   +1 more source