Results 241 to 250 of about 8,887,267 (401)

Targeted Protein Degradation for Agricultural Applications: Rationale, Challenges, and Outlook. [PDF]

ACS Bio Med Chem Au
Fourches D, Pilotte J, Watts BE, Saltzberg DJ, Cicchillo RM.   +4 more
europepmc   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

FBXO44-mediated RGS2 protein degradation uniquely depends on a novel Cullin 4B/DDB1 E3 ligase complex

, 2018
Benita Sjögren
openalex   +2 more sources

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Targeted protein degradation in Escherichia coli using CLIPPERs. [PDF]

EMBO Rep
Izert-Nowakowska MA, Klimecka MM, Antosiewicz A, Wróblewski K, Kowalski JJ, Bandyra KJ, Góral T, Kmiecik S, Serwa RA, Górna MW.   +9 more
europepmc   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Targeted protein degradation of Wnt/β-catenin signaling pathway: an effective strategy for cancer therapy. [PDF]

J Transl Med
Mao S, Zhang X, Zhao Y, Li X, Wang Z, Zhou P, Wang Z, Zhang X, Hu X, Huang G, Xie W.   +10 more
europepmc   +1 more source

Targeted protein degradation as a powerful research tool in basic biology and drug target discovery

Nature Structural & Molecular Biology, 2020
Tao Wu, Hojong Yoon, Yuan Xiong, S. Dixon-Clarke, R. Nowak, E. Fischer   +5 more
semanticscholar   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

De novo designed protein guiding targeted protein degradation. [PDF]

Nat Commun
Li Z, Qiao G, Wang X, Wang M, Cheng J, Hu G, Li X, Wu J, Liu J, Gao C, Liu L.   +10 more
europepmc   +1 more source