Results 61 to 70 of about 3,285 (194)

Structural, functional and proteomic changes of proteins during rice yellowing

Food Chemistry: X
High temperature storage (40 °C, 60 % relative humidity, 6 months) induces rice yellowing and affects protein properties. Physiochemical analysis revealed increased disulfide bonds, particle size, and surface hydrophobicity in yellowed rice protein ...
Yuqian Liu, Yanan Qv, Jingyu Sun, Xiao Zheng, Victoria Anthony Uyanga, Yawen Wang, Yu Cui, Caiyun Tang, Jinguang Liu, Yilun Chen   +9 more
doaj   +1 more source

Variation in the Subcellular Localization and Protein Folding Activity among Arabidopsis thaliana Homologs of Protein Disulfide Isomerase

Biomolecules, 2013
Protein disulfide isomerases (PDIs) catalyze the formation, breakage, and rearrangement of disulfide bonds to properly fold nascent polypeptides within the endoplasmic reticulum (ER). Classical animal and yeast PDIs possess two catalytic thioredoxin-like
Christen Y. L. Yuen, David A. Christopher, Kristie O. Matsumoto   +2 more
doaj   +1 more source

Interactome analyses identify ties of PrP and its mammalian paralogs to oligomannosidic N-glycans and endoplasmic reticulum-derived chaperones. [PDF]

PLoS Pathogens, 2009
The physiological environment which hosts the conformational conversion of the cellular prion protein (PrP(C)) to disease-associated isoforms has remained enigmatic.
Joel C Watts, Hairu Huo, Yu Bai, Sepehr Ehsani, Amy Hye Won Jeon, Tujin Shi, Nathalie Daude, Agnes Lau, Rebecca Young, Lei Xu, George A Carlson, David Williams, David Westaway, Gerold Schmitt-Ulms   +13 more
doaj   +1 more source

Folding of small disulfide-rich proteins : clarifying the puzzle [PDF]

, 2006
Premi a l'excel·lència investigadora. Àmbit de les Ciències Experimentals. 2008The process by which small proteins fold to their native conformations has been intensively studied over the last few decades.
Apuy, Arolas, Arolas, Arolas, Arolas, Baneyx, Bardwell, Cemazar, Cemazar, Chang, Chang, Chang, Chang, Chang, Chang, Chang, Chang, Chang, Chang, Chang, Chatrenet, Creighton, Creighton, Creighton, Creighton, Creighton, Daggett, Daly, Darby, Dobson, Ellgaard, Francesc X. Aviles, Fuller, Gehrmann, Goldberg, Goldenberg, Heitz, Hogg, Houry, Joan L. Arolas, Jui-Yoa Chang, Klein-Seetharaman, Kortemme, Kuhlman, Laity, Li, Lu, Matagne, Narayan, Narayan, Narayan, Narayan, Onuchic, Permyakov, Ross, Ruoppolo, Ruoppolo, Salamanca, Salvador Ventura, Scheraga, Shimotakahara, Shin, van den Berg, van den Berg, van Mierlo, van Mierlo, Venhudova, Wedemeyer, Weissman, Welker, Welker, Wu, Yang, Zavodszky   +73 more
core   +2 more sources

Protein disulfide isomerases – a way to tackle malaria

Trends in Parasitology, 2023
Protein disulfide isomerases (PDIs) ensure that specific substrate proteins are correctly folded. PDI activity plays an essential role in malaria transmission. Here we provide an overview of the role of PDIs in malaria-causing Plasmodium parasites and outline why PDI inhibition could be a novel way to treat malaria and prevent transmission.
Fiona Angrisano, Amelia Ford, Andrew Michael Blagborough, Hayley Elise Bullen   +3 more
openaire   +2 more sources

Nanozymes Integrated Biochips Toward Smart Detection System

Advanced Science, EarlyView.
This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen, Wang Zheng, Zhihui Zhang, Shenping Yu, Xinxin Hang, Han Wu, Xiao‐Wei Xiang, Wei Mu, Yanli Jiao, Zaizai Dong, Lingqian Chang   +10 more
wiley   +1 more source

Membralin Assembles a MAN1B1–VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation

Advanced Science, EarlyView.
This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Jing Zhang, Xiaoran Lu, Sunan Li, Tao Wang, Iqbal Ahmad, Yong‐Hui Zheng   +5 more
wiley   +1 more source

AGR2-mediated cell-cell communication controls the antiviral immune response by promoting the thiol oxidation of TRAF3

Redox Biology
Protein disulfide isomerases (PDIs) are essential catalysts for the formation and isomerization of disulfide bonds in diverse substrate proteins and exert multiple functions under pathophysiological conditions.
Mengqi Jia, Xiaojing Chen, Wenxue Guo, Dapeng Ma, Peng Wang, Huanmin Niu, Changhong Liu, Xianjuan Lin, QiQi Lu, Jing Wang, Xiaoxue Zheng, Qi Sun, Chengjiang Gao, Huiqing Yuan   +13 more
doaj   +1 more source

Cell-type specific requirements for thiol/disulfide exchange during HIV-1 entry and infection

Retrovirology, 2012
Background The role of disulfide bond remodeling in HIV-1 infection is well described, but the process still remains incompletely characterized. At present, the data have been predominantly obtained using established cell lines and/or CXCR4-tropic ...
Stantchev Tzanko S, Paciga Mark, Lankford Carla R, Schwartzkopff Franziska, Broder Christopher C, Clouse Kathleen A   +5 more
doaj   +1 more source

Protein Disulfide Isomerases Regulate IgE-Mediated Mast Cell Responses and Their Inhibition Confers Protective Effects During Food Allergy

Frontiers in Immunology, 2020
The thiol isomerase, protein disulfide isomerase (PDI), plays important intracellular roles during protein folding, maintaining cellular function and viability.
Dylan Krajewski, Stephanie H. Polukort, Justine Gelzinis, Jeffrey Rovatti, Edwin Kaczenski, Christine Galinski, Megan Pantos, Nickul N. Shah, Nickul N. Shah, Sallie S. Schneider, Sallie S. Schneider, Daniel R. Kennedy, Clinton B. Mathias, Clinton B. Mathias   +13 more
doaj   +1 more source