Results 81 to 90 of about 3,285 (194)

Prolyl 4-hydroxlase activity is essential for development and cuticle formation in the human infective parasitic nematode Brugia malayi [PDF]

, 2013
Collagen prolyl 4-hydroxylases (C-P4H) are required for formation of extracellular matrices in higher eukaryotes. These enzymes convert proline residues within the repeat regions of collagen polypeptides to 4-hydroxyproline, a modification essential for ...
Alan D. Winter, Antony P. Page, Bendtsen, Cox, Ellgaard, Evans, Ghedin, Gillian McCormack, Hotez, Jex, Johanna Myllyharju, John, Kamath, Kelly, Kivirikko, Koivunen, Lamberg, Landmann, Lappi, Lok, Maule, Merriweather, Mitreva, Myllyharju, Myllyharju, Myllyharju, Opperman, Ottesen, Page, Petralanda, Pirneskoski, Rajan, Riihimaa, Stiernagle, Takacs, Timmons, Wang, Winter, Winter, Winter, Winter   +40 more
core   +1 more source

Projected Warming of the Southern Ocean Disrupts Embryonic Development and Hatch Timing in Antarctic Fish

Global Change Biology Communications, EarlyView.
Embryos are particularly sensitive to thermal challenge. Antarctic fish embryos raised at projected Southern Ocean temperatures hatch during the winter, have a high incidence of morphological abnormalities, have shorter body lengths, and express genes indicative of cellular stress.
Margaret Streeter, Nathalie R. Le François, Thomas Desvignes, Jacob Grondin, John H. Postlethwait, H. William Detrich III, Jacob M. Daane   +6 more
wiley   +1 more source

ER Dysfunction and Protein Folding Stress in ALS [PDF]

, 2013
Amyotrophic lateral sclerosis (ALS) is the most frequent paralytic disease in adults. Most ALS cases are considered sporadic with no clear genetic component.
Hetz, Claudio, Matus, Soledad, Medinas, Danilo B., Valenzuela, Vicente   +3 more
core   +3 more sources

Biomarkers for the estimation of isoproterenol‐induced myocardial infarction: A review of key parameters

Journal of Intelligent Medicine, EarlyView.
Abstract The isoproterenol‐induced myocardial infarction model is a well‐established experimental approach for studying cardiac injury and testing potential protective treatments. By overstimulating beta‐adrenergic receptors, this model closely reproduces key features of human heart attacks, including oxidative damage, calcium imbalance, inflammatory ...
Bushra Imran, Tarique Mahmood, Farogh Ahsan, Shahzadi Bano, Vaseem Ahamad Ansari, Mohd Adnan   +5 more
wiley   +1 more source

Protein disulfide isomerase MoPdi1 regulates fungal development, virulence, and endoplasmic reticulum homeostasis in Magnaporthe oryzae

Journal of Integrative Agriculture
Rice blast, caused by Magnaporthe oryzae, is a fungal disease that causes devastating damage to rice production worldwide. During infection, pathogens secrete effector proteins that modulate plant immunity.
Yu Wang, Xiaoru Kang, Xinyue Cui, Jinmei Hu, Yuemin Pan, Yizhen Deng, Shulin Zhang   +6 more
doaj   +1 more source

Process Intensification for an Insect Antimicrobial Peptide Elastin-Like Polypeptide Fusion Produced in Redox-Engineered Escherichia coli

Frontiers in Bioengineering and Biotechnology, 2019
Peptides and proteins containing disulfide bonds can be produced in Escherichia coli by targeting the oxidizing periplasm, co-expressing isomerases or chaperons, refolding from inclusion bodies, or by using redox-engineered E. coli strains.
Mathias Joachim, Mathias Joachim, Nicolas Maguire, Johannes Schäfer, Doreen Gerlach, Peter Czermak, Peter Czermak, Peter Czermak   +7 more
doaj   +1 more source

Cell Propagation of Cholera Toxin CTA ADP-Ribosylating Factor by Exosome Mediated Transfer [PDF]

, 2018
In this study, we report how the cholera toxin (CT) A subunit (CTA), the enzyme moiety responsible for signaling alteration in host cells, enters the exosomal pathway, secretes extracellularly, transmits itself to a cell population.
Boussadia, Zaira, Carollo, Maria, Fabbri, Alessia, Falchi, Mario, Fecchi, Katia, Fiani, Maria Luisa, Gallina, Angelo, Palermo, Angela, Parisi, Sofia, Pasquini, Luca, Sargiacomo, Massimo, Zanetti, Cristiana   +11 more
core   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Decoding PDI diversity: Insights into structure, domains, and functionality in sorghum

Computational and Structural Biotechnology Journal
Proteins play indispensable roles in cellular function, acting as both structural components and catalysts for essential biological processes. Their proper folding into three-dimensional structures is critical for functionality. To ensure correct folding,
Carla F. López-Gómez, Marc T. Morris, Karen Massel, Millicent Smith, Peter Crisp, Gerhard Schenk, Ian D. Godwin   +6 more
doaj   +1 more source

Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins

eLife, 2018
Pharmacologic arm-selective unfolded protein response (UPR) signaling pathway activation is emerging as a promising strategy to ameliorate imbalances in endoplasmic reticulum (ER) proteostasis implicated in diverse diseases.
Ryan Paxman, Lars Plate, Erik A Blackwood, Chris Glembotski, Evan T Powers, R Luke Wiseman, Jeffery W Kelly   +6 more
doaj   +1 more source