Results 11 to 20 of about 1,414,042 (194)

Protein Binding Pocket Dynamics [PDF]

Accounts of Chemical Research, 2016
The dynamics of protein binding pockets are crucial for their interaction specificity. Structural flexibility allows proteins to adapt to their individual molecular binding partners and facilitates the binding process. This implies the necessity to consider protein internal motion in determining and predicting binding properties and in designing new ...
Stank, Antonia; Kokh, Dania B.; Fuller, Jonathan C.; Wade, Rebecca C.   +4 more
openaire   +4 more sources

Protein dynamics

FEBS Letters, 1994
Modern NMR has revitalized the study of protein dynamics. Multidimensional spectra and the heteronuclear spectroscopy allow a substantial gain in resolution. Dynamics can be analyzed at individual sites and data on segmental and sequence‐dependent flexibility are accumulating.
Jardetzky, Oleg, Lefèvre, Jean-François   +1 more
openaire   +2 more sources

Conformational dynamics of a single protein monitored for 24 hours at video rate [PDF]

, 2018
We use plasmon rulers to follow the conformational dynamics of a single protein for up to 24 h at a video rate. The plasmon ruler consists of two gold nanospheres connected by a single protein linker.
Ahijado-Guzmán, Rubén, Celiksoy, Sirin, Götz, Markus, Hugel, Thorsten, Prasad, Janak, Ratzke, Christoph, Ricken, Julia, Sönnichsen, Carsten, Tüting, Laura, Wegner, Seraphine V., Ye, Weixiang   +10 more
core   +3 more sources

Sec translocon has an insertase-like function in addition to polypeptide conduction through the channel [version 1; peer review: 4 approved]

F1000Research, 2019
The Sec translocon provides a polypeptide-conducting channel, which is insulated from the hydrophobic lipidic environment of the membrane, for translocation of hydrophilic passenger polypeptides.
Koreaki Ito, Naomi Shimokawa-Chiba, Shinobu Chiba   +2 more
doaj   +1 more source

Water Dynamics at Protein Interfaces: Ultrafast Optical Kerr Effect Study [PDF]

, 2012
The behavior of water molecules surrounding a protein can have an important bearing on its structure and function. Consequently, a great deal of attention has been focused on changes in the relaxation dynamics of water when it is located at the protein ...
Bizzarri A. R., Bizzarri A. R., Born B., Bucaro J. A., Castner E. W., Chang Y. J., Colaianni S. E. M., de Morais L. C., Eaves J. D., Ebbinghaus S., Eriksson K. O., Feig M., Giraud G., Halle B., Halle B., Hamm P., Heisler I. A., Heisler I. A., Heugen U., Heyden M., Hunt N. T., Hunt N. T., Hunt N. T., Hunt N. T., Ismael A. Heisler, James T. L., Kamila Mazur, Kato A., Kuntz I. D., Laage D., Laage D., Lang E. W., Lee B., Lee B., Lerbret A., Levy Y., Lotshaw W. T., Mahn A., Malardier-Jugroot C., Marchi M., Marti J., Mazur K., Mazur K., Mazzacurati V., McMorrow D., Mizoguchi K., Modig K., Moon Y. U., Murphy W. F., Nakayama T., Nandi N., Nielsen O. F., Ohmine I., Ohmine I., Paolantoni M., Perticaroli S., Potma E. O., Qvist J., Qvist J., Rejoumichel A., Rezus Y. L. A., Rupley J. A., Russo D., Shenogina N., Shirota H., Shirota H., Smith N. A., Stephen R. Meech, Stirnemann G., Torre R., Urabe H., Winkler K., Xu J., Yokoyama K., Zhong Q.   +74 more
core   +1 more source

Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins

Nature Communications, 2021
RaPID (Random non-standard Peptides Integrated Discovery) enables discovery of small macrocyclic peptides binding desired targets. Here, the authors propose lasso-grafting: the RaPID-derived peptides are implanted onto diverse proteins and maintain both ...
Emiko Mihara, Satoshi Watanabe, Nasir K. Bashiruddin, Nozomi Nakamura, Kyoko Matoba, Yumi Sano, Rumit Maini, Yizhen Yin, Katsuya Sakai, Takao Arimori, Kunio Matsumoto, Hiroaki Suga, Junichi Takagi   +12 more
doaj   +1 more source

Are Protein Shape-Encoded Lowest-Frequency Motions a Key Phenotype Selected by Evolution?

Applied Sciences, 2023
At the very deepest molecular level, the mechanisms of life depend on the operation of proteins, the so-called “workhorses” of the cell. Proteins are nanoscale machines that transform energy into useful cellular work, such as ion or nutrient transport ...
Laura Orellana
doaj   +1 more source

Epigenetic mechanisms to propagate histone acetylation by p300/CBP

Nature Communications, 2023
Histone acetylation is important for the activation of gene transcription but little is known about its direct read/write mechanisms. Here, we report cryogenic electron microscopy structures in which a p300/CREB-binding protein (CBP) multidomain monomer ...
Masaki Kikuchi, Satoshi Morita, Masatoshi Wakamori, Shin Sato, Tomomi Uchikubo-Kamo, Takehiro Suzuki, Naoshi Dohmae, Mikako Shirouzu, Takashi Umehara   +8 more
doaj   +1 more source

Two domains of Tim50 coordinate translocation of proteins across the two mitochondrial membranes

Life Science Alliance, 2023
Biochemical and genetic experiments identify distinct roles of the two domains of Tim50 in the intermembrane space during translocation of proteins into the mitochondria via the TOM and TIM23 complexes.
Marcel G Genge, Shalini Roy Chowdhury, Vít Dohnálek, Kaori Yunoki, Takashi Hirashima, Toshiya Endo, Pavel Doležal, Dejana Mokranjac   +7 more
doaj   +1 more source

Prediction of Functional Sites in SCOP Domains using Dynamics Perturbation Analysis [PDF]

, 2008
Dynamics perturbation analysis (DPA) finds regions in a protein structure where proteins are "ticklish", i.e., where interactions cause a large change in protein dynamics.
Dengming Ming, Judith D. Cohn, Michael E. Wall   +2 more
core   +2 more sources