Results 41 to 50 of about 1,414,042 (194)
Nature CommunicationsProtein conformational changes are the cornerstone of biological function. While conformers captured experimentally represent metastable states, the pathways connecting them have been elusive for experiments and simulations alike.
Domenico Scaramozzino +2 more
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Vein fate determined by flow-based but time-delayed integration of network architecture
eLife, 2023 Veins in vascular networks, such as in blood vasculature or leaf networks, continuously reorganize, grow or shrink, to minimize energy dissipation. Flow shear stress on vein walls has been set forth as the local driver for a vein’s continuous adaptation.
Sophie Marbach +4 more
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Protein folding tames chaos [PDF]
, 2013 Protein folding produces characteristic and functional three-dimensional structures from unfolded polypeptides or disordered coils. The emergence of extraordinary complexity in the protein folding process poses astonishing challenges to theoretical ...
Wei, Guo-Wei, Xia, Kelin
core
Probing protein-protein interactions by dynamic force correlated spectroscopy (FCS)
, 2005 We develop a formalism for single molecule dynamic force spectroscopy to map the energy landscape of protein-protein complex ($P_1$$P_2$). The joint distribution $P(\tau_1,\tau_2)$ of unbinding lifetimes $\tau_1$ and $\tau_2$ measurable in a compression ...
A. Ashkin +4 more
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Pyrone-based inhibitors of metalloproteinase types 2 and 3 may work as conformation-selective inhibitors. [PDF]
, 2011 Matrix metalloproteinases are zinc-containing enzymes capable of degrading all components of the extracellular matrix. Owing to their role in human disease, matrix metalloproteinase have been the subject of extensive study.
de Oliveira, César AF +2 more
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Resolving Protein Structure Dynamically [PDF]
Structure, 2005 In this issue of Structure, Rajagopal et al. (2005) report further innovations in the X-ray diffraction analysis of the dynamical changes in protein conformation; they use these methods to resolve the light-activated changes in the conformation of Photoactive Yellow Protein. This approach allows a straightforward reinforcement of X-ray diffraction data
Yeremenko, S., Hellingwerf, K.J.
openaire +3 more sources
Biology Open, 2020 In the anterior foregut (AFG) of mouse embryos, the transcription factor SOX2 is expressed in the epithelia of the esophagus and proximal branches of respiratory organs comprising the trachea and bronchi, whereas NKX2.1 is expressed only in the epithelia
Machiko Teramoto +7 more
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Stochastic single-molecule dynamics of synaptic membrane protein domains
, 2016 Motivated by single-molecule experiments on synaptic membrane protein domains, we use a stochastic lattice model to study protein reaction and diffusion processes in crowded membranes.
Haselwandter, Christoph A. +2 more
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Molecular Dynamics Studies on the Buffalo Prion Protein [PDF]
, 2015 It was reported that buffalo is a low susceptibility species resisting to prion diseases, which are invariably fatal and highly infectious neurodegenerative diseases that affect a wide variety of species.
Chatterjee, Subhojyoti +2 more
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Quantitative Protein Dynamics from Dominant Folding Pathways
, 2007 We develop a theoretical approach to the protein folding problem based on out-of-equilibrium stochastic dynamics. Within this framework, the computational difficulties related to the existence of large time scale gaps in the protein folding problem are ...
F. Pederiva +6 more
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