Results 51 to 60 of about 1,414,042 (194)
Viscosity-Dependent Protein Dynamics [PDF]
Biophysical Journal, 2007 Spectrally resolved stimulated vibrational echo spectroscopy is used to investigate the dependence of fast protein dynamics on bulk solution viscosity at room temperature in four heme proteins: hemoglobin, myoglobin, a myoglobin mutant with the distal histidine replaced by a valine (H64V), and a cytochrome c552 mutant with the distal methionine ...
Finkelstein, Ilya J. +2 more
openaire +2 more sources
Towards a Stochastic Paradigm: From Fuzzy Ensembles to Cellular Functions
Molecules, 2018 The deterministic sequence → structure → function relationship is not applicable to describe how proteins dynamically adapt to different cellular conditions. A stochastic model is required to capture functional promiscuity, redundant sequence
Monika Fuxreiter
doaj +1 more source
Cytosolic calcium regulates cytoplasmic accumulation of TDP-43 through Calpain-A and Importin α3
eLife, 2020 Cytoplasmic accumulation of TDP-43 in motor neurons is the most prominent pathological feature in amyotrophic lateral sclerosis (ALS). A feedback cycle between nucleocytoplasmic transport (NCT) defect and TDP-43 aggregation was shown to contribute to ...
Jeong Hyang Park +12 more
doaj +1 more source
Communications Biology, 2021 Kanako Shimizu et al. identify HLA-A24 high-binding epitopes in the SARS-CoV-2 spike region and investigate their cross-reactivity with CD8+ T cell receptors.
Kanako Shimizu +11 more
doaj +1 more source
Blind protein structure prediction using accelerated free-energy simulations. [PDF]
, 2016 We report a key proof of principle of a new acceleration method [Modeling Employing Limited Data (MELD)] for predicting protein structures by molecular dynamics simulation.
Brini, Emiliano +4 more
core +1 more source
Structural basis of Gip1 for cytosolic sequestration of G protein in wide-range chemotaxis
Nature Communications, 2018 Gip1 sequesters heterotrimeric G proteins in the cytosolic pool which regulates G protein-coupled receptor signalling for eukaryotic chemotaxis. Here the authors provide the crystal structure of Gip1's G protein-binding region and show that mutations in ...
Takero Miyagawa +6 more
doaj +1 more source
A topological approach for protein classification
, 2015 Protein function and dynamics are closely related to its sequence and structure. However prediction of protein function and dynamics from its sequence and structure is still a fundamental challenge in molecular biology.
Cang, Zixuan +5 more
core +1 more source
Identifying the protein folding nucleus using molecular dynamics [PDF]
, 2000 Molecular dynamics simulations of folding in an off-lattice protein model reveal a nucleation scenario, in which a few well-defined contacts are formed with high probability in the transition state ensemble of conformations.
Buldyrev, Sergey V. +3 more
core +1 more source
Evidence of a low-temperature dynamical transition in concentrated microgels [PDF]
, 2018 A low-temperature dynamical transition has been reported in several proteins. We provide the first observation of a `protein-like' dynamical transition in nonbiological aqueous environments.
Bertoldo, Monica +7 more
core +3 more sources
Nature Communications, 2021 The basement membrane is located at tissue interfaces, but how it mediates distinct inter-tissue interactions is unclear. Here, the authors systematically define the spatial heterogeneity of skin basement membrane composition and show its functional ...
Ko Tsutsui +7 more
doaj +1 more source