Results 211 to 220 of about 8,269,032 (242)
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Protein engineering and design
Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1989Rapid advances in site-directed mutagenesis and total gene synthesis combined with new expression systems in prokaryotic and eukaryotic cells have provided the molecular biologist with tools for modification of existing proteins to improve catalytic activity, stability and selectivity, for construction of chimeric molecules and for synthesis of ...
Blundell, T L +16 more
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Current Opinion in Biotechnology, 1995
Much of the research on integral membrane proteins mirrors that on soluble proteins; however, membrane protein engineering also has its own ends and means, many of which take advantage of the peculiar situation of membrane proteins, whose chains are distributed between one lipidic and two aqueous phases. Extramembrane loops have been shortened, cut, or
Matti Saraste, Jean-Luc Popot
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Much of the research on integral membrane proteins mirrors that on soluble proteins; however, membrane protein engineering also has its own ends and means, many of which take advantage of the peculiar situation of membrane proteins, whose chains are distributed between one lipidic and two aqueous phases. Extramembrane loops have been shortened, cut, or
Matti Saraste, Jean-Luc Popot
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Protein engineering of amylases
Biochemical Society Transactions, 1992Introduction Amylases of varying specificity catalyse the degradation of starch and related oligoand poly-saccharides 111. These enzymes occur widely in plants, animals and micro-organisms and many, in particular those of bacterial or fungal origin, are used in the starch industry.
Morten Søgaard, Birte Svensson
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Protein engineering in bioelectrocatalysis
Current Opinion in Biotechnology, 2003Electrochemistry of redox proteins is a broadly applicable technology with important applications in biosensors, biofuel cells and chemical syntheses. Escalating attention in this area is driven by remarkable progress in designing efficient interfaces for transferring electrons between electrode surfaces and redox proteins. Research in interface design
Ulrich Schwaneberg, Tuck Seng Wong
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Self-play reinforcement learning guides protein engineering
Nature Machine Intelligence, 2023Yi Wang +7 more
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Physiology, 2003
Proteins that belong to the ATP-binding cassette superfamily span from bacteria to humans and comprise one of the largest protein families. These proteins are characterized by the presence of two nucleotide-binding domains, and recent studies suggest that association and dissociation of these domains is a common basic molecular mechanism of operation ...
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Proteins that belong to the ATP-binding cassette superfamily span from bacteria to humans and comprise one of the largest protein families. These proteins are characterized by the presence of two nucleotide-binding domains, and recent studies suggest that association and dissociation of these domains is a common basic molecular mechanism of operation ...
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Protein engineering of cellulases
Current Opinion in Biotechnology, 2014This review covers the topic of protein engineering of cellulases, mostly after 2009. Two major trends that are identified in this work are: first, the increased importance of results from computational protein engineering to drive ideas in the field, as experimental ideas and results often are still scarce, and, second, the further development of ...
Jay H. Lee +5 more
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Protein engineering: the potential of remote mutations.
Biochemical Society Transactions, 2019Engineered proteins, especially enzymes, are now commonly used in many industries owing to their catalytic power, specific binding of ligands, and properties as materials and food additives.
M. Wilding +4 more
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Protein engineering of subtilisin
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 2000The serine protease subtilisin is an important industrial enzyme as well as a model for understanding the enormous rate enhancements affected by enzymes. For these reasons along with the timely cloning of the gene, ease of expression and purification and availability of atomic resolution structures, subtilisin became a model system for protein ...
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Engineering proteins for purification
Trends in Biotechnology, 1990Over the past decade, a new protein purification technique has emerged as a result of recombinant DNA technology. DNA, encoding additional polypeptide or protein tags, is fused to the gene of interest. Expression of these gene fusions results in protein fusions which may be purified by techniques using the properties of the additional polypeptide tag ...
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