Results 51 to 60 of about 29,093 (266)

Atrial fibrillation and its arrhythmogenesis associated with insulin resistance

Cardiovascular Diabetology, 2019
Background Insulin resistance (IR) is considered as a risk factor for atrial fibrillation (AF) even before diabetes develops. The pathophysiology and underlying mechanism are largely unclear.
Yi-Hsin Chan, Gwo-Jyh Chang, Ying-Ju Lai, Wei-Jan Chen, Shang-Hung Chang, Li-Man Hung, Chi-Tai Kuo, Yung-Hsin Yeh   +7 more
doaj   +1 more source

Inhibition of KCa3.1 Channels Suppresses Atrial Fibrillation via the Attenuation of Macrophage Pro-inflammatory Polarization in a Canine Model With Prolonged Rapid Atrial Pacing

Frontiers in Cardiovascular Medicine, 2021
Aims: To investigate the role of KCa3. 1 inhibition in macrophage pro-inflammatory polarization and vulnerability to atrial fibrillation (AF) in a canine model with prolonged rapid atrial pacing.Materials and Methods: Twenty beagle dogs (weighing 8–10 kg)
Shanqing He, Shanqing He, Shanqing He, Youcheng Wang, Youcheng Wang, Youcheng Wang, Yajun Yao, Yajun Yao, Yajun Yao, Zhen Cao, Zhen Cao, Zhen Cao, Junkui Yin, Junkui Yin, Junkui Yin, Liuliu Zi, Liuliu Zi, Liuliu Zi, Huiyu Chen, Huiyu Chen, Huiyu Chen, Yuntao Fu, Yuntao Fu, Yuntao Fu, Xi Wang, Xi Wang, Xi Wang, Qingyan Zhao, Qingyan Zhao, Qingyan Zhao   +29 more
doaj   +1 more source

Time‐Resolved SAXS Reveals Distinct Millisecond Metal‐Induced Conformational Dynamics of Monomeric α‐Synuclein

Advanced Science, EarlyView.
Time‐resolved SAXS reveals how physiologically relevant metal ions shape the earliest conformational responses of monomeric α‐synuclein. Fe3+ induces rapid compaction, Cu2+ generates heterogeneous and partially folded ensembles, while Mn2+ and Zn2+ cause only modest changes.
Rebecca Sternke‐Hoffmann, Miriam Dos Santos Pinto, Xue Wang, Jinghui Luo   +3 more
wiley   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

S100B chaperone multimers suppress the formation of oligomers during Aβ42 aggregation

Frontiers in Neuroscience, 2023
Extracellular aggregation of the amyloid-β 1–42 (Aβ42) peptide is a major hallmark of Alzheimer’s disease (AD), with recent data suggesting that Aβ intermediate oligomers (AβO) are more cytotoxic than mature amyloid fibrils.
António J. Figueira, António J. Figueira, Joana Saavedra, Joana Saavedra, Joana Saavedra, Isabel Cardoso, Isabel Cardoso, Isabel Cardoso, Cláudio M. Gomes, Cláudio M. Gomes   +9 more
doaj   +1 more source

Inhibition of Familial Cerebral Amyloid Angiopathy Mutant Amyloid β-Protein Fibril Assembly by Myelin Basic Protein [PDF]

Journal of Biological Chemistry, 2007
Deposition of fibrillar amyloid beta-protein (Abeta) in the brain is a prominent pathological feature of Alzheimer disease and related disorders, including familial forms of cerebral amyloid angiopathy (CAA). Mutant forms of Abeta, including Dutch- and Iowa-type Abeta, which are responsible for familial CAA, deposit primarily as fibrillar amyloid along
Michael D, Hoos, Mahiuddin, Ahmed, Steven O, Smith, William E, Van Nostrand   +3 more
openaire   +2 more sources

3D Bioprinted Fat‐Myocardium Model Unravels the Role of Adipocyte Hypertrophy in Atrial Dysfunction

Advanced Science, EarlyView.
A human‐derived 3D bioprinted fat–myocardium model is developed to investigate how adipocyte hypertrophy drives atrial dysfunction in obesity. Palmitate‐induced adipocyte hypertrophy promotes adipose dysfunction that impairs atrial cardiomyocyte metabolism and electrophysiology through both paracrine and direct interactions. This platform recapitulates
Lara Ece Celebi, Pinar Zorlutuna
wiley   +1 more source

Plant Extracts and Phytochemicals Targeting α-Synuclein Aggregation in Parkinson's Disease Models

Frontiers in Pharmacology, 2019
α-Synuclein (α-syn) is a presynaptic protein that regulates the release of neurotransmitters from synaptic vesicles in the brain. α-Syn aggregates, including Lewy bodies, are features of both sporadic and familial forms of Parkinson's disease (PD). These
Hayate Javed, Mohamed Fizur Nagoor Meeran, Sheikh Azimullah, Abdu Adem, Bassem Sadek, Shreesh Kumar Ojha   +5 more
doaj   +1 more source

Ubiquitin C-terminal hydrolase 1 inhibits the ubiquitination of CaMK Ⅱ and promots the occurrence of atrial fibrillation in rats

陆军军医大学学报, 2022
Objective To analyze the role and molecular mechanisms underlying of ubiquitin C-terminal hydrolase 1 (UCHL1) in promoting atrial fibrillation (AF). Methods Forty 8-week-old male SD rats (240~260 g) were randomly divided into four groups, with 10 rats in
LI Liying, FANG Li, QI Heng, ZOU Bin, YUAN Cong, GUO Yuxuan   +5 more
doaj   +1 more source

Inhibition of the formation of amyloid β‐protein fibrils using biocompatible nanogels as artificial chaperones [PDF]

FEBS Letters, 2006
The formation of fibrils by amyloid β‐protein (Aβ) is considered as a key step in the pathology of Alzheimer's disease (AD). Inhibiting the aggregation of Aβ is a promising approach for AD therapy. In this study, we used biocompatible nanogels composed of a polysaccharide pullulan backbone with hydrophobic cholesterol moieties (cholesterol‐bearing ...
Ikeda, Keisuke, Okada, Takuma, Sawada, Shin-ichi, Akiyoshi, Kazunari, Matsuzaki, Katsumi   +4 more
openaire   +2 more sources