Results 91 to 100 of about 3,689,678 (299)

Automated Quantification of Amyloid Fibrils Morphological Features by Image Processing Techniques

, 2019
International audienceImage analysis of protein fibrils is a key step for a quantitative understanding of the mechanisms responsible for aggregation and deposition of amyloids.
Prigent, Stephanie, Doumic, Marie, Marie Doumic, Torrent, Joan, Drasdo, Dirk, Dirk Drasdo, Joan Torrent, Yin, Yi, Yi Yin, Stephanie Prigent, Human Rezaei, Rezaei, Human   +11 more
core   +1 more source

Formation and properties of amyloid fibrils of prion protein [PDF]

Biophysical Reviews, 2017
Amyloid fibrils formed from prion protein (PrP) are associated with prion diseases. In this review we discuss a number of extrinsic and intrinsic experimental factors related to the formation of PrP amyloid fibrils in vitro. We first examined the effects of ultrasonic power on the induction of amyloid fibrillation from PrP.
Kei-ichi Yamaguchi, Kazuo Kuwata
openaire   +2 more sources

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Effects of NaCl and CaCl2 on the Growth Process and Morphology of Soy Protein Isolate Fibrils

Shipin gongye ke-ji
To explore effects of common metal chlorides (NaCl and CaCl2) in food system on the growth process and morphology of soy protein isolate (SPI) fibrils.
Bingbing YUAN, Hekai ZHAO, Shizhang YAN, Yang LI   +3 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Acid-denatured small heat shock protein HdeA from Escherichia coli forms reversible fibrils with an atypical secondary structure [PDF]

The periplasmic small heat shock protein HdeA from Escherichia coli is inactive under normal growth conditions (at pH 7) and activated only when E. coli cells are subjected to a sudden decrease in pH, converting HdeA into an acid-denatured active state ...
80335504, 本郷, 邦広, 河田, 康志, 26874, 26873, Kawata, Yasushi, 溝端, 知宏, 50263489, Miyawaki, Shiori, カワタ, ヤスシ, 100000572, 1457, 100000496, 100000563, 2225, Mizobata, Tomohiro, Uemura, Yumi, 779, 40177697, Hongo, Kunihiro, ミゾバタ, トモヒロ, ホンゴウ, クニヒロ   +21 more
core   +1 more source

Ultrasonic-Assisted Acid Heat Treatment for the Preparation and Structural Characteristics of Pea Protein Fibers

Liang you shipin ke-ji
In this study, pea protein isolate (PPI) was used as the raw material to prepare pea protein isolate fibrils (PPIF) through ultrasound-assisted acid-thermal treatment. The effects of ultrasound and acid-thermal treatment on the physicochemical properties
REN Yu-kai, MOU Song-song, LI Zhi, BAI Ke-fei, LIU Xin-yi, WANG Yu-sheng, CHEN Hai-hua   +6 more
doaj   +1 more source

Inhibition of synucleinopathic seeding by rationally designed inhibitors

eLife, 2020
Seeding, in the context of amyloid disease, is the sequential transfer of pathogenic protein aggregates from cell-to-cell within affected tissues. The structure of pathogenic seeds provides the molecular basis and enables rapid conversion of soluble ...
Smriti Sangwan, Shruti Sahay, Kevin A Murray, Sophie Morgan, Elizabeth L Guenther, Lin Jiang, Christopher K Williams, Harry V Vinters, Michel Goedert, David S Eisenberg   +9 more
doaj   +1 more source