Results 131 to 140 of about 3,689,678 (299)

Cytochrome Display on Amyloid Fibrils

, 2016
Protein amyloid fibrils can be functionalized by coating the core protofilament with high concentrations of proteins and enzymes. This can be done elegantly by appending a functional domain to an amyloidogenic protein monomer, then assembling the ...
John Christodoulou (450398), Cait E. MacPhee (419987), Paul D. Barker (1355991), Reto Bader (2399167), Andrew J. Baldwin (1358124), Christopher M. Dobson (181572)   +5 more
core   +1 more source

Structural polymorphism of α-synuclein fibrils alters the pathway of Hsc70-mediated disaggregation

The EMBO Journal
Pathological aggregation of α-synuclein into amyloid fibrils is a hallmark of synucleinopathies, including Parkinson’s disease. Despite this commonality, synucleinopathies display divergent disease phenotypes that have been attributed to disease-specific
Svenja Jäger, Jessica Tittelmeier, Thi Lieu Dang, Tracy Bellande, Virginie Redeker, Alexander K Buell, Janosch Hennig, Ronald Melki, Carmen Nussbaum-Krammer, Bernd Bukau, Anne S Wentink   +10 more
doaj   +1 more source

Selective observation of semi-rigid non-core residues in dynamically complex mutant huntingtin protein fibrils. [PDF]

J Struct Biol X, 2022
Matlahov I, Boatz JC, van der Wel PCA.
europepmc   +1 more source

Guanosine‐Quadruplex Hydrogels as Dynamic, Mechanically Tunable and Ion Conductive 3D Scaffolds for Cell Culture Applications

Advanced Functional Materials, EarlyView.
Versatile guanosine‐quadruplex (GQ) hydrogels are developed as dynamic biomatrices for cell culture. These scaffolds are fabricated under mild aqueous conditions, present improved stability, tunable mechanical properties within physiological ranges; fibrillar, porous microstructure, ion conductivity, and cytocompatibility.
Neha Thakur, Minye Jin, Pavel Milkin, Deepa Negi, Carla Cofiño Fabres, Hubert Gojzewski, Leonid Ionov, Alla Synytska, Andries van der Meer, Robert Passier, Julieta I. Paez   +10 more
wiley   +1 more source

Utilizing the Metastability of Spidroins as a Strategy for Improving Mechanical Properties of Biomimetic Spider Silk Fibers

Advanced Functional Materials, EarlyView.
Phase transitions are central for the assembly of recombinant silk proteins into fibers. Soluble protein can transition into condensed states such as condensates and gels. These states are metastable and evolve in a time‐dependent way. Metastability depends on the protein sequence, and this relationship can be used to enhance the mechanical properties ...
Fred‐Eric Sammalisto, Topias Lankinen, Celine Tallroth, Rafael A. Lara, Matilda Backholm, Markus B. Linder   +5 more
wiley   +1 more source

Using a stable protein scaffold to display peptides that bind to alpha-synuclein fibrils. [PDF]

Amyloid fibrils are ordered aggregates that are a pathological hallmark of many neurodegenerative disorders including Alzheimer's disease and Parkinson's disease.

core   +7 more sources

Structural basis for amyloid fibril assembly by the master cell-signaling regulator receptor-interacting protein kinase 1

Nature Communications
Amyloid fibrils can form biologically relevant functional assemblies. The RIP homotypic interaction motifs (RHIMs) in receptor-interacting protein kinases 1 and 3 (RIPK1 and RIPK3) orchestrate the formation of amyloid-like fibrils essential for ...
Paula Polonio, Jorge Pedro López-Alonso, Hanxing Jiang, Sara Andrés-Campos, Fátima C. Escobedo-González, Gustavo A. Titaux-Delgado, Iban Ubarretxena-Belandia, Miguel Mompeán   +7 more
doaj   +1 more source

Dynamic Observation of Lacy Pattern Formation in a Bone Tissue Model Using Liquid Phase Scanning Transmission Electron Microscopy

Advanced Functional Materials, EarlyView.
Here, we establish a low‐dose liquid‐phase electron microscopy workflow for real‐time observation of biological processes in hydrated conditions. Beam damage is reduced by imaging only 20% of the pixels and reconstructing the complete image using an inpainting algorithm.
Luco Rutten, Avital Wagner, Rona Roverts, Luco Buise, Ben Joosten, Anat Akiva, Elena Macías‐Sánchez, Nico Sommerdijk   +7 more
wiley   +1 more source

Effect of Fibril Entanglement on Pickering Emulsions Stabilized by Whey Protein Fibrils for Nobiletin Delivery. [PDF]

Foods, 2022
Jiang F, Chen C, Wang X, Huang W, Jin W, Huang Q.   +5 more
europepmc   +1 more source

Remote Activation of Wnt Signaling and Cell Proliferation by E‐Cadherin Magnetomechanical Stimulation

Advanced Functional Materials, EarlyView.
A pioneering magnetogenetic toolkit enables non‐invasive, precise spatiotemporal modulation of intracellular Wnt/β‐catenin signaling. Functionalized magnetic nanoparticles (MNPs@E/EC15) target cellular E‐cadherins to generate localized magnetomechanical forces under low‐intensity magnetic fields.
Christian Castro‐Hinojosa, Pablo Martínez‐Vicente, Lucía G. Recaredo, Susel Del Sol‐Fernández, Pilar Gomollón‐Zueco, Yilian Fernández‐Afonso, Raluca M. Fratila, María Moros   +7 more
wiley   +1 more source