Results 91 to 100 of about 257,652 (357)
Cooperativity and Frustration in Protein-Mediated Parallel Actin Bundles
, 2009 We examine the mechanism of bundling of cytoskeletal actin filaments by two representative bundling proteins, fascin and espin. Small-angle X-ray studies show that increased binding from linkers drives a systematic \textit{overtwist} of actin filaments ...
B. Alberts +6 more
core +1 more source
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source
Rad51 polymerization reveals a new chromatin remodeling mechanism. [PDF]
PLoS ONE, 2008 Rad51 protein is a well known protagonist of homologous recombination in eukaryotic cells. Rad51 polymerization on single-stranded DNA and its role in presynaptic filament formation have been extensively documented.
Pauline Dupaigne +7 more
doaj +1 more source
Transforming growth factor-beta targets Formin-like 2 for Angiopoietin-like 4 secretion during the epithelial mesenchymal transition [PDF]
, 2019 Epithelial to Mesenchymal transition (EMT) is a highly dynamic process that plays a crucial role in tumor progression and metastasis. While remodelling of the actin cytoskeleton is a hallmark of EMT, the responsible actin regulating factors are less well
Moussi, Christel Jessica
core +1 more source
The Syp1/FCHo2 protein induces septin filament bundling through its intrinsically disordered domain [PDF]
, 2022 Sandy Ibanes +9 more
openalex +1 more source
Quantifying Protein Diffusion and Capture on Filaments [PDF]
Biophysical Journal, 2015 13 pages, 7 ...
Reithmann, Emanuel +2 more
openaire +3 more sources
Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen +18 more
wiley +1 more source
Catastrophic disassembly of actin filaments via Mical-mediated oxidation. [PDF]
, 2017 Actin filament assembly and disassembly are vital for cell functions. MICAL Redox enzymes are important post-translational effectors of actin that stereo-specifically oxidize actin's M44 and M47 residues to induce cellular F-actin disassembly.
Ge, Peng +6 more
core +3 more sources
Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan +22 more
wiley +1 more source
Predicting Protein Producibility in Filamentous Fungi [PDF]
, 2017 AbstractIn this paper we study the problem of predicting the producibility of recombinant proteins in filamentous fungi, especially T. reesei, using machine learning methods. We train supervised and semi-supervised support vector machines with protein sequences, represented by their amino acid composition as well as protein family and domain ...
Dykstra, Karmen L +2 more
openaire +1 more source