Results 71 to 80 of about 3,575,397 (313)
Two-photon excited LIF determination of H-atom concentrations near a heated filament in a low pressure H2 environment [PDF]
, 1990 Meier U, Kohse-Höinghaus K, Schäfer L, Klages C-P. Two-photon excited LIF determination of H-atom concentrations near a heated filament in a low pressure H2 environment. Applied Optics.
Kohse-Höinghaus, Katharina +3 more
core
Pyramidalization of the Glycosidic Nitrogen Provides the Way for Efficient Cleavage of the N‑Glycosidic Bond of 8‑OxoG with the hOGG1 DNA Repair Protein [PDF]
, 2012 A mechanistic pathway for cleavage of the N-glycosidic bond of 8-oxo-2′-deoxyguanosine (oxoG) catalyzed with the human 8-oxoguanine glycosylase 1 DNA repair protein (hOGG1) is proposed in this theoretical study. The reaction scheme suggests direct proton
Sychrovský, V. +5 more
core +1 more source
Scientific Reports, 2018 The minus-end-directed microtubule motor cytoplasmic dynein requires the dynactin complex for in vivo functions. The backbone of the vertebrate dynactin complex is the Arp1 (actin-related protein 1) mini-filament whose barbed end binds to the ...
Jun Zhang, Rongde Qiu, Xin Xiang
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The interaction between the HPV E1^E4 protein and the cell cytoskeleton. [PDF]
, 2007 Papillomaviruses are small DNA viruses, which cause benign and malignant lesions in the differentiated epithelium of mammals and birds. A small subset of human papillomaviruses (HPV's), have been identified as the etiological agent of cervical cancer ...
Laskey, P.
core
Structural basis for stabilisation of the RAD51 nucleoprotein filament by BRCA2
Nature Communications, 2023 The BRCA2 tumour suppressor protein preserves genomic integrity via interactions with the DNA-strand exchange RAD51 protein in homology-directed repair.
Robert Appleby +3 more
doaj +1 more source
Frontiers in Microbiology, 2021 FlgN, FliS, and FliT are flagellar export chaperones specific for FlgK/FlgL, FliC, and FliD, respectively, which are essential component proteins for filament formation.
Tohru Minamino +6 more
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
CAPG (capping protein (actin filament), gelsolin-like) [PDF]
, 2010 Review on CAPG (capping protein (actin filament), gelsolin-like), with data on DNA, on the protein encoded, and where the gene is ...
Singh, PK, R Tamuli, Tamuli, R, PK Singh
core +1 more source
Frontiers in Soft MatterGelsolin is a calcium (Ca2+) dependent, pH sensitive actin-binding protein that regulates actin filament dynamics to remodel the actin cytoskeleton. It is known that gelsolin binding induces conformational changes of actin filaments, leading to filament ...
Taylor V. Douglas +10 more
doaj +1 more source