Results 51 to 60 of about 3,575,397 (313)
Cysteine-rich protein 2 accelerates actin filament cluster formation. [PDF]
PLoS ONE, 2017 Filamentous actin (F-actin) forms many types of structures and dynamically regulates cell morphology and movement, and plays a mechanosensory role for extracellular stimuli. In this study, we determined that the smooth muscle-related transcription factor,
Takanori Kihara +4 more
doaj +1 more source
Order and disorder in intermediate filament proteins [PDF]
FEBS Letters, 2015 Intermediate filaments (IFs), important components of the cytoskeleton, provide a versatile, tunable network of self‐assembled proteins. IF proteins contain three distinct domains: an α‐helical structured rod domain, flanked by intrinsically disordered head and tail domains.
Kornreich, Micha +4 more
openaire +2 more sources
Deimination, Intermediate Filaments and Associated Proteins [PDF]
International Journal of Molecular Sciences, 2020 Deimination (or citrullination) is a post-translational modification catalyzed by a calcium-dependent enzyme family of five peptidylarginine deiminases (PADs). Deimination is involved in physiological processes (cell differentiation, embryogenesis, innate and adaptive immunity, etc.) and in autoimmune diseases (rheumatoid arthritis, multiple sclerosis ...
Briot, Julie +2 more
openaire +2 more sources
The recruitment of acetylated and unacetylated tropomyosin to distinct actin polymers permits the discrete regulation of specific myosins in fission yeast. [PDF]
, 2010 Tropomyosin (Tm) is a conserved dimeric coiled-coil protein, which forms polymers that curl around actin filaments in order to regulate actomyosin function.
Mulvihill, Daniel P. +9 more
core +1 more source
Biochemical characterization of actin assembly mechanisms with ALS-associated profilin variants
European Journal of Cell Biology, 2022 Eight separate mutations in the actin-binding protein profilin-1 have been identified as a rare cause of amyotrophic lateral sclerosis (ALS). Profilin is essential for many neuronal cell processes through its regulation of lipids, nuclear signals, and ...
Xinbei Liu +4 more
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Stabilization of the cortical cytoskeleton by the lipid raft-associated protein cap23 [PDF]
, 2006 In the present work, we identified the lipid raft-associated protein Cap23 to be involved in several important neuronal functions like the organization of lipid raft platforms, the maturation and stabilization of the actin- and intermediate filament ...
Wacha, Stefan
core +1 more source
The Effects of Hsp90α1 Mutations on Myosin Thick Filament Organization. [PDF]
PLoS ONE, 2015 Heat shock protein 90α plays a key role in myosin folding and thick filament assembly in muscle cells. To assess the structure and function of Hsp90α and its potential regulation by post-translational modification, we developed a combined knockdown and ...
Qiuxia He +3 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Organized unidirectional waves of ATP hydrolysis within a RecA filament.
PLoS Biology, 2005 The RecA protein forms nucleoprotein filaments on DNA, and individual monomers within the filaments hydrolyze ATP. Assembly and disassembly of filaments are both unidirectional, occurring on opposite filament ends, with disassembly requiring ATP ...
Julia M Cox +2 more
doaj +1 more source