Results 251 to 260 of about 3,575,397 (313)

Targeted Degradation of STING by a Neutrophil Membrane‐Coated Nanoplatform Suppresses Microglial Pyroptosis After Subarachnoid Hemorrhage

Advanced Science, EarlyView.
MG1@NM‐Px serves as a microglia‐targeted STING‐degrading nanoplatform for subarachnoid hemorrhage. Following systemic administration, it crosses the blood–brain barrier and accumulates in activated microglia. STP1‐mediated STING ubiquitination and degradation suppress MAPK/inflammasome signaling, GSDME‐mediated pyroptosis, and IL‐1β release, revealing ...
Ruotian Zhang, Kaikun Yuan, Haoyu Zou, Hanfeng Qin, Jiale Liu, Jianda Sun, Feifan Zhang, Yuankui Wang, Tong Wang, Jiaxing Dai, Chunxu Li, Yichi Chen, Yingfeng Tu, Huaizhang Shi   +13 more
wiley   +1 more source

Structural and dynamic basis of NOD2 tandem CARD association and NOD1/2-RIP2 signaling complexes. [PDF]

PLoS Comput Biol
Maharana J, Bej A, Biswal D, Panda D, Sharma A.   +4 more
europepmc   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

Nucleostemin promotes RAD51 filament assembly on double-stranded DNA to protect stalled replication forks. [PDF]

Nucleic Acids Res
Chang CC, Tsai SS, Chou CL, Chang YH, Hung CT, Tsai RYL, Li HW, Liaw H, Chi P.   +8 more
europepmc   +1 more source

Zasp52's differentially expressed intrinsically disordered region confers thin filament stability at the Z-disc. [PDF]

Elife
Ho N, Schöck F.
europepmc   +1 more source

Vimentin's Journey from "Background Scaffold" to Multi-Scale Regulator of Neuronal Growth and Function: Historical, Conceptual and Epistemic Perspectives. [PDF]

Int J Mol Sci
Gebreselase BA, Minin AA.
europepmc   +1 more source

From Pixels to Patterns: A Multidimensional Framework to Decode Cytoskeletal Organization. [PDF]

Comput Struct Biotechnol J
Vieira DF, Figueiredo J, Sanches J.
europepmc   +1 more source

Structures of EHD2 filaments on curved membranes provide a model for caveolar neck stabilization. [PDF]

Nat Commun
Vázquez-Sarandeses E, Mikirtumov V, Noel JK, Kudryashev M, Daumke O.   +4 more
europepmc   +1 more source

Structural basis for a filamentous morpheein model of human cystathionine beta-synthase. [PDF]

Nat Commun
Mohammed I, Mijatovic E, Philipp TM, Janickova L, Ascencao K, Asturias FJ, Martinez-Cruz LA, Szabo C, Stahlberg H, Majtan T.   +9 more
europepmc   +1 more source

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Structural transition in a filamentous protein

Journal of Molecular Biology, 1976
The filamentous bacterial virus Pf1 exhibits two distinct fiber diffraction patterns. The transition between these patterns can best be explained by a fractional change in the number of units per turn in the coat protein helix. The stereochemistry of the transition has been examined for a detailed molecular model, and found to be energetically feasible.
E J, Wachtel, F J, Marvin, D A, Marvin
openaire   +2 more sources