Results 271 to 280 of about 3,575,397 (313)

Hamiltonian Dynamics of Protein Filament Formation

Physical Review Letters, 2016
We establish the Hamiltonian structure of the rate equations describing the formation of protein filaments. We then show that this formalism provides a unified view of the behavior of a range of biological self-assembling systems as diverse as actin, prions, and amyloidogenic polypeptides.
Thomas C. T. Michaels, Samuel I. A. Cohen, Michele Vendruscolo, Christopher M. Dobson, Tuomas P. J. Knowles   +4 more
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A new neuronal intermediate filament protein

Trends in Neurosciences, 1989
It would be an understatement to say that the vertebrate nervous system appears complex. The characterization and classification of its components rely, in addition to its gross anatomy, on analyses of the differential expression of cytoskeletal and other cellular structures and products.
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Heterologous protein expression in filamentous fungi

Trends in Biotechnology, 2005
Filamentous fungi are commonly used in the fermentation industry for the large-scale production of proteins--mainly industrial enzymes. Recent advances in fungal genomics and related experimental technologies such as gene arrays and proteomics are rapidly changing the approaches to the development and use of filamentous fungi as hosts for the ...
K M Helena, Nevalainen, Valentino S J, Te'o, Peter L, Bergquist   +2 more
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Production of recombinant proteins by filamentous fungi

Biotechnology Advances, 2012
The initial focus of recombinant protein production by filamentous fungi related to exploiting the extraordinary extracellular enzyme synthesis and secretion machinery of industrial strains, including Aspergillus, Trichoderma, Penicillium and Rhizopus species, was to produce single recombinant protein products.
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Myogenesis and the Intermediate Filament Protein, Nestin

Developmental Biology, 1994
We show that the intermediate filament protein nestin is expressed in myogenic cells and that multiple mechanisms regulate nestin expression at different stages of myogenesis. Cultured embryonic, fetal, and neonatal mouse limb myoblasts initially expressed nestin in the absence of the four muscle regulatory factors (MRFs) of the MyoD family, whereas ...
A M, Kachinsky, J A, Dominov, J B, Miller   +2 more
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Improving the display of proteins on filamentous phage

Research in Microbiology, 2001
In phage display technology, polypeptides are displayed on the surface of filamentous bacteriophage by genetic fusion to a coat protein. However, the fraction of phage particles bearing the fusion protein can be low. Here we found that we could improve the display of a protein (Stoffel fragment of Taq polymerase fused to the p3 protein of the phage) by
J L, Jestin, G, Volioti, G, Winter
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Crystallographic Studies of Intermediate Filament Proteins

2017
Intermediate filaments (IFs), together with microtubules and actin microfilaments, are the three main cytoskeletal components in metazoan cells. IFs are formed by a distinct protein family, which is made up of 70 members in humans. Most IF proteins are tissue- or organelle-specific, which includes lamins, the IF proteins of the nucleus.
Dmytro, Guzenko, Anastasia A, Chernyatina, Sergei V, Strelkov   +2 more
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Implications of intermediate filament protein phosphorylation

Cancer and Metastasis Review, 1996
Intermediate filament (IF) proteins, a large family of tissue specific proteins, undergo several posttranslational modifications, with phosphorylation being the most studied modification. IF protein phosphorylation is highly dynamic and involves the head and/or tail domains of these proteins, which are the domains that impart most of the structural ...
N O, Ku, J, Liao, C F, Chou, M B, Omary
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Intermediate Filament Proteins and Their Associated Diseases

New England Journal of Medicine, 2004
Intermediate filaments provide scaffolding for the cell and protect it against stress. This comprehensive review points out that there are more than 100 intermediate filament genes and that mutant intermediate filament proteins cause more than 30 diseases.
M Bishr, Omary, Pierre A, Coulombe, W H Irwin, McLean   +2 more
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Evolutionary aspects in intermediate filament proteins

Current Opinion in Cell Biology, 2015
Intermediate filament (IF) proteins, together with tubulins and actins, constitute the majority of cytoskeletal proteins in metazoans. Proteins of the IF family fulfil increasingly diverse functions but share common structural features. Phylogenetic analysis within the metazoan lineage traces back their origin to a common lamin-like ancestor.
Annette, Peter, Reimer, Stick
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