Results 1 to 10 of about 162,600 (208)

New insight into protein glycosylation in the development of Alzheimer’s disease [PDF]

Cell Death Discovery, 2023
Alzheimer’s disease (AD) is a chronic neurodegenerative disease that seriously endangers the physical and mental health of patients, however, there are still no effective drugs or methods to cure this disease up to now.
Jingwei Zhao, Minglin Lang
doaj   +2 more sources

Integrative glycomic analysis reveals the crucial role of protein glycosylation in fungal pathogenesis. [PDF]

PLoS Pathogens
Protein glycosylation, a co- and post-translational modification that enhances the functional diversity of the proteome, contributes to various molecular and cellular functions by transferring different polysaccharides onto proteins.
Heeji Moon, Eun Jung Thak, Yejin Choi, Sieun Kim, Jiyeun Park, Nahyun Lee, Soobin Shin, Hosung Jeon, Jessica Winarto, Soyoung Choi, Ji Young Shin, Jung-Eun Kim, Dae-Geun Song, Hun Kim, Gyung Ja Choi, Hyun Ah Kang, Hokyoung Son   +16 more
doaj   +2 more sources

The Impact of Methanol Concentration on Recombinant Protein Glycosylation in Pichia pastoris SuperMan5 [PDF]

Microbial Biotechnology
The methylotrophic yeast Pichia pastoris (also known as Komagataella phaffii) is a prominent platform for recombinant protein production, offering benefits such as thermo‐ and osmotolerance, high‐density growth, and efficient protein secretion.
Andre Ohara, Zhang Pengyue, Xinqi Cao, Roberto Donini, Stuart M. Haslam, Karen M. Polizzi   +5 more
doaj   +2 more sources

Defining the impact of flavivirus envelope protein glycosylation site mutations on sensitivity to broadly neutralizing antibodies [PDF]

mBio
Antibodies targeting an envelope dimer epitope (EDE) cross-neutralize Zika virus (ZIKV) and dengue virus (DENV) and have thus inspired an epitope-focused vaccine design. There are two EDE antibody subclasses (EDE1, EDE2) distinguished by their dependence
Maya Contreras, Jackson B. Stuart, Lisa M. Levoir, Laura Belmont, Leslie Goo   +4 more
doaj   +2 more sources

Effects of β-Glucan Glycosylation on Functional Properties and Antioxidant Activity of Naked Oat Protein

Shipin gongye ke-ji, 2022
Naked oat protein and β-glucan were used to conduct glycosylation reaction. The functional indexes of naked oat protein before and after glycosylation were determined.
Zhiwei YANG, Lin JIANG
doaj   +1 more source

Glycosylation of viral proteins: Implication in virus–host interaction and virulence

Virulence, 2022
Glycans are among the most important cell molecular components. However, given their structural diversity, their functions have not been fully explored. Glycosylation is a vital post-translational modification for various proteins.
Tingting Feng, Jinyu Zhang, Zhiqian Chen, Wen Pan, Zhengrong Chen, Yongdong Yan, Jianfeng Dai   +6 more
doaj   +1 more source

Sculpting the Bacterial O-Glycoproteome: Functional Analyses of Orthologous Oligosaccharyltransferases with Diverse Targeting Specificities

mBio, 2022
Protein glycosylation systems are widely recognized in bacteria, including members of the genus Neisseria. In most bacterial species, the molecular mechanisms and evolutionary contexts underpinning target protein selection and the glycan repertoire ...
Chris Hadjineophytou, Jan Haug Anonsen, Tina Svingerud, Tatum D. Mortimer, Yonatan H. Grad, Nichollas E. Scott, Michael Koomey   +6 more
doaj   +1 more source

N-glycoproteomic profiling revealing novel coronavirus therapeutic targets potentially involved in Cepharanthine's intervention

Medicine in Novel Technology and Devices, 2022
The Coronavirus disease 2019 (COVID-19) has posed a serious threat to global health and the world economy. Antiviral therapies targeting coronavirus are urgently required. The Cepharanthine (CEP) is a traditional Chinese herbal extract.
Wenlin An, Fengjuan Tian, Jing Li, Junge Chen, Yigang Tong   +4 more
doaj   +1 more source

ERO1 alpha deficiency impairs angiogenesis by increasing N-glycosylation of a proangiogenic VEGFA

Redox Biology, 2022
N-glycosylation and disulfide bond formation are two essential steps in protein folding that occur in the endoplasmic reticulum (ER) and reciprocally influence each other.
Ersilia Varone, Alexander Chernorudskiy, Alessandro Cherubini, Angela Cattaneo, Angela Bachi, Stefano Fumagalli, Gizem Erol, Marco Gobbi, Michael J. Lenardo, Nica Borgese, Ester Zito   +10 more
doaj   +1 more source

Transglutaminase-Catalyzed Glycosylation Improved Physicochemical and Functional Properties of Lentinus edodes Protein Fraction

Foods, 2023
Lentinula edodes has high nutritional value and abundant protein. In order to develop and utilize edible mushroom protein, this study was designed to investigate the effects of TGase-catalyzed glycosylation and cross-linking on the physicochemical and ...
Shan-shan Wu, Wei Han, Yan-fen Cheng, Shao-jun Yun, Ming-chang Chang, Fei-er Cheng, Jin-ling Cao, Cui-ping Feng   +7 more
doaj   +1 more source