Results 11 to 20 of about 1,237,822 (372)

Fundamentals of protein interaction network mapping

Molecular Systems Biology, 2015
Studying protein interaction networks of all proteins in an organism (“interactomes”) remains one of the major challenges in modern biomedicine. Such information is crucial to understanding cellular pathways and developing effective therapies for the ...
Jamie Snider, Max Kotlyar, Punit Saraon, Zhong Yao, Igor Jurisica, Igor Stagljar   +5 more
doaj   +6 more sources

Systematic protein–protein interaction mapping for clinically relevant human GPCRs [PDF]

Molecular Systems Biology, 2017
G‐protein‐coupled receptors (GPCRs) are the largest family of integral membrane receptors with key roles in regulating signaling pathways targeted by therapeutics, but are difficult to study using existing proteomics technologies due to their complex ...
Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar   +27 more
doaj   +3 more sources

RNA-protein interaction mapping via MS2- or Cas13-based APEX targeting. [PDF]

Proc Natl Acad Sci U S A, 2020
Significance The biogenesis, processing, function, and degradation of cellular RNAs depend critically on their protein interaction partners. Systematic analysis of the protein interactome of specific RNAs of interest inside living cells can therefore ...
Han S, Zhao BS, Myers SA, Carr SA, He C, Ting AY.   +5 more
europepmc   +3 more sources

High-resolution protein-protein interaction mapping using all-versus-all sequencing (AVA-Seq). [PDF]

J Biol Chem, 2019
Two-hybrid systems can be used for investigating protein–protein interactions and may provide important information about gene products with unknown function.
Andrews SS, Schaefer-Ramadan S, Al-Thani NM, Ahmed I, Mohamoud YA, Malek JA.   +5 more
europepmc   +2 more sources

Nasopharyngeal Carcinoma Protein Interaction Mapping Analysis via Proteomic Approaches [PDF]

Asian Pac J Cancer Prev, 2018
Nasopharyngeal carcinoma (NPC), although not very common in many parts of the world, is a major concern in some countries, including Iran. Molecular studies are very helpful to provide essential information regarding underlying carcinogenetic mechanisms.
Zamanian Azodi M, Rezaei Tavirani M, Rezaei Tavirani M, Vafaee R, Rostami-Nejad M.   +4 more
europepmc   +2 more sources

Protein Interaction Mapping related to Becker Muscular Dystrophy. [PDF]

Iran J Child Neurol, 2019
Objective Becker Muscular Dystrophy (BMD) is a neuromuscular disorder which is incurable. In this research protein interaction network of most associated proteins with BMD to provide better clarification of disorder underlying mechanism was investigated.
Peyvandi AA, Okhovatian F, Rezaei Tavirani M, Zamanian Azodi M, Rezaei Tavirani M.   +4 more
europepmc   +2 more sources

From nonspecific DNA-protein encounter complexes to the prediction of DNA-protein interactions. [PDF]

PLoS Computational Biology, 2009
DNA-protein interactions are involved in many essential biological activities. Because there is no simple mapping code between DNA base pairs and protein amino acids, the prediction of DNA-protein interactions is a challenging problem. Here, we present a
Mu Gao, Jeffrey Skolnick
doaj   +11 more sources

Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states

eLife, 2016
To improve chemical cross-linking of proteins coupled with mass spectrometry (CXMS), we developed a lysine-targeted enrichable cross-linker containing a biotin tag for affinity purification, a chemical cleavage site to separate cross-linked peptides away
Dan Tan, Qiang Li, Mei-Jun Zhang, Chao Liu, Chengying Ma, Pan Zhang, Yue-He Ding, Sheng-Bo Fan, Li Tao, Bing Yang, Xiangke Li, Shoucai Ma, Junjie Liu, Boya Feng, Xiaohui Liu, Hong-Wei Wang, Si-Min He, Ning Gao, Keqiong Ye, Meng-Qiu Dong, Xiaoguang Lei   +20 more
doaj   +2 more sources

Bio::Homology::InterologWalk - A Perl module to build putative protein-protein interaction networks through interolog mapping

BMC Bioinformatics, 2011
Background Protein-protein interaction (PPI) data are widely used to generate network models that aim to describe the relationships between proteins in biological systems. The fidelity and completeness of such networks is primarily limited by the paucity
Armstrong J Douglas, Simpson T Ian, Gallone Giuseppe, Jarman Andrew P   +3 more
doaj   +2 more sources

Duchenne Muscular Dystrophy (DMD) Protein-Protein Interaction Mapping. [PDF]

Iran J Child Neurol, 2017
Objective Duchenne muscular dystrophy (DMD) is one of the mortal diseases, subjected to study in terms of molecular investigation. In this study, the protein interaction map of this muscle-wasting condition was generated to gain a better knowledge of ...
Rezaei Tavirani M, OkHOVATIAN F, Zamanian Azodi M, Rezaei Tavirani M.   +3 more
europepmc   +2 more sources