Results 11 to 20 of about 543,220 (340)
Fundamentals of protein interaction network mapping
Molecular Systems Biology, 2015 Studying protein interaction networks of all proteins in an organism (“interactomes”) remains one of the major challenges in modern biomedicine. Such information is crucial to understanding cellular pathways and developing effective therapies for the ...
Jamie Snider +5 more
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Mapping protein-DNA interactions with DiMeLo-seq [PDF]
Nature Protocols, 2022 AbstractWe recently developedDirectedMethylation withLong-readsequencing (DiMeLo-seq) to map protein-DNA interactions genome wide. DiMeLo-seq is capable of mapping multiple interaction sites on single DNA molecules, profiling protein binding in the context of endogenous DNA methylation, identifying haplotype specific protein-DNA interactions, and ...
Annie Maslan +8 more
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Detecting Mutually Exclusive Interactions in Protein-Protein Interaction Maps
PLoS ONE, 2012 Comprehensive protein interaction maps can complement genetic and biochemical experiments and allow the formulation of new hypotheses to be tested in the system of interest. The computational analysis of the maps may help to focus on interesting cases and thereby to appropriately prioritize the validation experiments.
Carmen Sanchez Claros, TRAMONTANO, ANNA
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Protein-protein interaction map for yeast TFIID [PDF]
Nucleic Acids Research, 2003 A major rate-limiting step in transcription initiation by RNA polymerase II is recognition and binding of the TATA element by the transcription factor TFIID. TFIID is composed of TATA binding protein (TBP) and approximately a dozen TBP-associated factors (TAFs).
Gayatri, Yatherajam +3 more
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Comparison of human protein–protein interaction maps [PDF]
Bioinformatics, 2007 AbstractMotivation: Large-scale mappings of protein–protein interactions have started to give us new views of the complex molecular mechanisms inside a cell. After initial projects to systematically map protein interactions in model organisms such as yeast, worm and fly, researchers have begun to focus on the mapping of the human interactome. To tackle
Matthias E, Futschik +2 more
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Pan-cancer mapping of differential protein-protein interactions [PDF]
Scientific Reports, 2020 AbstractDeciphering the variations in the protein interactome is required to reach a systems-level understanding of tumorigenesis. To accomplish this task, we have considered the clinical and transcriptome data on >6000 samples from The Cancer Genome Atlas for 12 different cancers.
Gulfidan, Gizem +4 more
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Mapping oncogenic protein interactions for precision medicine [PDF]
International Journal of Cancer, 2022 AbstractNormal protein‐protein interactions (normPPIs) occur with high fidelity to regulate almost every physiological process. In cancer, this highly organised and precisely regulated network is disrupted, hijacked or reprogrammed resulting in oncogenic protein‐protein interactions (oncoPPIs). OncoPPIs, which can result from genomic alterations, are a
Mehdi Sharifi Tabar +4 more
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PathExpand: Extending biological pathways using molecular interaction networks [PDF]
, 2011 We present a methodology for extending pre-defined protein sets representing cellular pathways and processes by mapping them onto a protein-protein interaction network, and extending them to include densely interconnected interaction partners.
Alfonso Valencia +3 more
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Identification of Breast Cancer Biomarkers by Constructing Protein-Protein Interaction and miRNAs-mRNAs Networks [PDF]
Middle East Journal of CancerBackground: In cancer-related diseases, early detection and control of disease progression are very important for successful treatment. Breast cancer is a significant problem due to its high mortality rate in the female population worldwide. By the early
Azizeh Asadzadeh +3 more
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Mapping Soluble Guanylyl Cyclase and Protein Disulfide Isomerase Regions of Interaction. [PDF]
PLoS ONE, 2015 Soluble guanylyl cyclase (sGC) is a heterodimeric nitric oxide (NO) receptor that produces cyclic GMP. This signaling mechanism is a key component in the cardiovascular system.
Erin J Heckler +5 more
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