Results 61 to 70 of about 1,237,822 (372)
Fair Evaluation of Global Network Aligners [PDF]
, 2014 Biological network alignment identifies topologically and functionally conserved regions between networks of different species. It encompasses two algorithmic steps: node cost function (NCF), which measures similarities between nodes in different ...
Crawford, Joseph +2 more
core +2 more sources
Nature Communications, 2016 Mapping protein-protein interaction using crosslinking and mass spectroscopy strategies is hampered by a high rate of false-positive results. Here, the authors develop a genetically encoded photo-affinity probe for accurate identification of protein ...
Yi Yang +8 more
doaj +1 more source
ppiTrim: Constructing non-redundant and up-to-date interactomes [PDF]
, 2011 Robust advances in interactome analysis demand comprehensive, non-redundant and consistently annotated datasets. By non-redundant, we mean that the accounting of evidence for every interaction should be faithful: each independent experimental support is ...
Stojmirović, Aleksandar, Yu, Yi-Kuo
core +3 more sources
A protein interaction map for cell polarity development [PDF]
The Journal of Cell Biology, 2001 Many genes required for cell polarity development in budding yeast have been identified and arranged into a functional hierarchy. Core elements of the hierarchy are widely conserved, underlying cell polarity development in diverse eukaryotes. To enumerate more fully the protein–protein interactions that mediate cell polarity development, and to uncover
Becky Drees +21 more
openaire +3 more sources
Determining protein complex connectivity using a probabilistic deletion network derived from quantitative proteomics. [PDF]
PLoS ONE, 2009 Protein complexes are key molecular machines executing a variety of essential cellular processes. Despite the availability of genome-wide protein-protein interaction studies, determining the connectivity between proteins within a complex remains a major ...
Mihaela E Sardiu +6 more
doaj +1 more source
Structure-aware protein-protein interaction site prediction using deep graph convolutional network
Bioinform., 2021 MOTIVATION Protein-protein interactions (PPI) play crucial roles in many biological processes, and identifying PPI sites is an important step for mechanistic understanding of diseases and design of novel drugs.
Qianmu Yuan +4 more
semanticscholar +1 more source
A first-draft human protein-interaction map [PDF]
Genome Biology, 2004 Abstract Background Protein-interaction maps are powerful tools for suggesting the cellular functions of genes. Although large-scale protein-interaction maps have been generated for several invertebrate species, projects of a similar scale have not yet been described for any mammal.
Ben Lehner, Andrew G. Fraser
openaire +3 more sources
Protein interaction mapping with ribosome-displayed using PLATO ORF libraries [PDF]
, 2014 Identifying physical interactions between proteins and other molecules is a critical aspect of biological analysis. Here we describe PLATO, an in vitro method for mapping such interactions by affinity enrichment of a library of full-length open reading ...
Church, George +11 more
core +1 more source
Mapping protein‐protein interactions with combinatorial peptides [PDF]
Comparative and Functional Genomics, 2001 Now that a number of genomes have been sequenced, attention has turned to understanding the complement of proteins encoded by the genome, which has been termed the ‘proteome’. One important aspect of analysis of the proteome is the identification of which proteins interact with each other; this information is invaluable in surmising the function of ...
openaire +3 more sources
MAP-ping Unconventional Protein-DNA Interactions [PDF]
Cell, 2009 Control of gene expression depends on a myriad of protein-DNA interactions, and the number of proteins involved just got larger. In this issue, Hu et al. (2009) identify hundreds of human proteins that bind to DNA, including many surprises such as the protein kinase ERK2 (MAPK1) that now appears to control gene expression directly.
Eric M. Wauson +2 more
openaire +3 more sources