Results 1 to 10 of about 220,671 (87)

Identification of Key Genes and Pathways in Peripheral Blood Mononuclear Cells of Type 1 Diabetes Mellitus by Integrated Bioinformatics Analysis [PDF]

Diabetes & Metabolism Journal, 2022
Background The onset and progression of type 1 diabetes mellitus (T1DM) is closely related to autoimmunity. Effective monitoring of the immune system and developing targeted therapies are frontier fields in T1DM treatment.
Xing Li, Mingyu Liao, Jiangheng Guan, Ling Zhou, Rufei Shen, Min Long, Jiaqing Shao   +6 more
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Detecting mutually exclusive interactions in protein-protein interaction maps. [PDF]

PLoS ONE, 2012
Comprehensive protein interaction maps can complement genetic and biochemical experiments and allow the formulation of new hypotheses to be tested in the system of interest.
Carmen Sánchez Claros, Anna Tramontano
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Recent Advances in Protein Homology Detection Propelled by Inter-Residue Interaction Map Threading

Frontiers in Molecular Biosciences, 2021
Sequence-based protein homology detection has emerged as one of the most sensitive and accurate approaches to protein structure prediction. Despite the success, homology detection remains very challenging for weakly homologous proteins with divergent ...
Sutanu Bhattacharya, Rahmatullah Roche, Md Hossain Shuvo, Debswapna Bhattacharya, Debswapna Bhattacharya   +4 more
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Network-based protein-protein interaction prediction method maps perturbations of cancer interactome.

PLoS Genetics, 2021
The perturbations of protein-protein interactions (PPIs) were found to be the main cause of cancer. Previous PPI prediction methods which were trained with non-disease general PPI data were not compatible to map the PPI network in cancer.
Jiajun Qiu, Kui Chen, Chunlong Zhong, Sihao Zhu, Xiao Ma   +4 more
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Identifying Potential Biomarkers in Colorectal Cancer and Developing Non-invasive Diagnostic Models Using Bioinformatics Approaches [PDF]

Avicenna Journal of Medical Biochemistry, 2020
Background: Colorectal cancer (CRC) is one of the most frequent causes of gastrointestinal tumors. Due to the invasiveness of the current diagnostic methods, there is an urgent need to develop non-invasive diagnostic approaches for CRC.
Massoud Saidijam, Saeid Afshar, Amir Taherkhani   +2 more
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Cost-Effective Mapping of Genetic Interactions in Mammalian Cells

Frontiers in Genetics, 2021
Comprehensive maps of genetic interactions in mammalian cells are daunting to construct because of the large number of potential interactions, ~ 2 × 108 for protein coding genes. We previously used co-inheritance of distant genes from published radiation
Arshad H. Khan, Desmond J. Smith
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Prediction of Coffee Effects in Rats with Healthy and NAFLD Conditions Based on Protein-Protein Interaction Network Analysis [PDF]

Research Journal of Pharmacognosy, 2019
Background and objectives: Non-alcoholic fatty liver disease (NAFLD) is a common liver condition. On the other hand, coffee consumption has shown promising for gastrointestinal diseases.
Majid Rezaei-Tavirani, Mostafa Rezaei Tavirani, Mona Zamanian Azodi*, Zahra Akbari, Homa Hajimehdipoor   +4 more
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Identification of significant genes and pathways associated with tenascin-C in cancer progression by bioinformatics analysis

Advanced Biomedical Research, 2022
Background: Tenascin-C (TNC) is a large glycoprotein of the extracellular matrix which associated with poor clinical outcomes in several malignancies. TNC over-expression is repeatedly observed in several cancer tissues and promotes several processes in ...
Ilnaz Rahimmanesh, Razieh Fatehi, Hossein Khanahmad   +2 more
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Identification of Pathways and Key Genes in Venous Remodeling After Arteriovenous Fistula by Bioinformatics Analysis

Frontiers in Physiology, 2020
The arteriovenous fistula (AVF) is the first choice for vascular access for hemodialysis of renal failure patients. Venous remodeling after exposure to high fistula flow is important for AVF to mature but the mechanism underlying remodeling is still ...
Kong Jie, Wang Feng, Zhao Boxiang, Gong Maofeng, Zhang Jianbin, Lu Zhaoxuan, Zhou Yangyi, Chen Liang, Su Haobo, Lou Wensheng, Chen Guoping, Gu Jianping, He Xu, Wen Jianyan   +13 more
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Improving Protein–Ligand Interaction Modeling with cryo-EM Data, Templates, and Deep Learning in 2021 Ligand Model Challenge

Biomolecules, 2023
Elucidating protein–ligand interaction is crucial for studying the function of proteins and compounds in an organism and critical for drug discovery and design.
Nabin Giri, Jianlin Cheng
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