Results 11 to 20 of about 1,208,117 (287)
Comparison of Human Protein-Protein Interaction Maps [PDF]
Bioinformatics, 2007 AbstractMotivation: Large-scale mappings of protein–protein interactions have started to give us new views of the complex molecular mechanisms inside a cell. After initial projects to systematically map protein interactions in model organisms such as yeast, worm and fly, researchers have begun to focus on the mapping of the human interactome. To tackle
M. Futschik +3 more
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Building protein interaction maps for Down's syndrome. [PDF]
Briefings in Functional Genomics and Proteomics, 2004 Now that the complete sequences for human chromosome 21 and the orthologous mouse genomic regions are known, reasonably complete, conserved, protein-coding gene catalogues are also available. The central issue now facing Down's syndrome researchers is the correlation of increased expression of specific, normal, chromosome 21 genes with the development ...
K. Gardiner, M. Davisson, L. Crnic
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Protein-protein interaction and gene co-expression maps of ARFs and Aux/IAAs in Arabidopsis
Frontiers in Plant Science, 2014 The phytohormone auxin regulates nearly all aspects of plant growth and development. Based on the current model in Arabidopsis thaliana, Auxin/indole-3-acetic acid (Aux/IAA) proteins repress auxin-inducible genes by inhibiting auxin response ...
Sarbottam ePiya +4 more
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Functional maps of protein complexes from quantitative genetic interaction data.
PLoS Computational Biology, 2008 Recently, a number of advanced screening technologies have allowed for the comprehensive quantification of aggravating and alleviating genetic interactions among gene pairs.
Sourav Bandyopadhyay +3 more
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PLoS Computational Biology, 2007 Yeast two-hybrid screens are an important method for mapping pairwise physical interactions between proteins. The fraction of interactions detected in independent screens can be very small, and an outstanding challenge is to determine the reason for the ...
Hailiang Huang +2 more
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Building disease-specific drug-protein connectivity maps from molecular interaction networks and PubMed abstracts. [PDF]
PLoS Computational Biology, 2009 The recently proposed concept of molecular connectivity maps enables researchers to integrate experimental measurements of genes, proteins, metabolites, and drug compounds under similar biological conditions.
Jiao Li, Xiaoyan Zhu, Jake Yue Chen
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A first-draft human protein-interaction map [PDF]
Genome Biology, 2004 BackgroundProtein-interaction maps are powerful tools for suggesting the cellular functions of genes. Although large-scale protein-interaction maps have been generated for several invertebrate species, projects of a similar scale have not yet been ...
Ben Lehner, A. Fraser
semanticscholar +3 more sources
Mapping protein–DNA interactions with DiMeLo-seq [PDF]
Nature Protocols, 2022 AbstractWe recently developedDirectedMethylation withLong-readsequencing (DiMeLo-seq) to map protein-DNA interactions genome wide. DiMeLo-seq is capable of mapping multiple interaction sites on single DNA molecules, profiling protein binding in the context of endogenous DNA methylation, identifying haplotype specific protein-DNA interactions, and ...
Annie Maslan +8 more
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Protein-protein interaction map for yeast TFIID [PDF]
Nucleic Acids Research, 2003 A major rate-limiting step in transcription initiation by RNA polymerase II is recognition and binding of the TATA element by the transcription factor TFIID. TFIID is composed of TATA binding protein (TBP) and approximately a dozen TBP-associated factors (TAFs).
Gayatri, Yatherajam +3 more
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Pan-cancer mapping of differential protein-protein interactions [PDF]
Scientific Reports, 2020 AbstractDeciphering the variations in the protein interactome is required to reach a systems-level understanding of tumorigenesis. To accomplish this task, we have considered the clinical and transcriptome data on >6000 samples from The Cancer Genome Atlas for 12 different cancers.
Gulfidan, Gizem +4 more
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