Results 21 to 30 of about 1,208,117 (287)

Mapping oncogenic protein interactions for precision medicine [PDF]

International Journal of Cancer, 2022
AbstractNormal protein‐protein interactions (normPPIs) occur with high fidelity to regulate almost every physiological process. In cancer, this highly organised and precisely regulated network is disrupted, hijacked or reprogrammed resulting in oncogenic protein‐protein interactions (oncoPPIs). OncoPPIs, which can result from genomic alterations, are a
Mehdi Sharifi Tabar, Habib Francis, Dannel Yeo, Charles G. Bailey, John E. J. Rasko   +4 more
openaire   +2 more sources

Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Blueprints of in-cell protein interaction landscapes are essential for our understanding of cellular structures and functions, which have been challenging to study at the systems level.
Andrew J Wheat, Clinton Yu, Xiaorong Wang, A. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter R Baker, S. Rychnovsky, Jing Yang, Lan Huang   +9 more
semanticscholar   +1 more source

Integrating genetic and protein-protein interaction networks maps a functional wiring diagram of a cell.

Current Opinion in Microbiology, 2018
Systematic experimental approaches have led to construction of comprehensive genetic and protein-protein interaction networks for the budding yeast, Saccharomyces cerevisiae.
Benjamin VanderSluis, M. Costanzo, Maximilian Billmann, Henry N. Ward, C. Myers, B. Andrews, Charles Boone   +6 more
semanticscholar   +1 more source

NaviCell: a web-based environment for navigation, curation and maintenance of large molecular interaction maps [PDF]

, 2013
Molecular biology knowledge can be systematically represented in a computer-readable form as a comprehensive map of molecular interactions. There exist a number of maps of molecular interactions containing detailed description of various cell mechanisms.
Barillot, Emmanuel, Calzone, Laurence, Cohen, David, Kuperstein, Inna, Pook, Stuart, Viara, Eric, Zinovyev, Andrei   +6 more
core   +5 more sources

Identification of therapeutic target genes with DNA microarray in multiple myeloma cell line treated by IKKβ/NF-κB inhibitor [PDF]

Acta Cirúrgica Brasileira, 2014
PURPOSE: To explore the mechanism of resistance to IKKβ inhibitor in multiple myeloma (MM) cells and uncover novel therapeutic targets for MM.METHODS: We downloaded the microarray data (GSE8476) from GEO (Gene Expression Omnibus) database.
Aixia Dou, Zhilun Wang, Jingjie Zhao, Junli Liu, Chengyun Zheng   +4 more
doaj   +1 more source

Comprehensive exploration of JQ1 and GSK2801 targets in breast cancer using network pharmacology and molecular modeling approaches

Computational and Structural Biotechnology Journal, 2023
JQ1 and GSK2801 are bromo domain inhibitors (BDI) known to exhibit enhanced anti-cancer activity when combined with other agents. However, the underlying molecular mechanisms behind such enhanced activity remain unclear.
Nanda Kumar Yellapu, Dong Pei, Emily Nissen, Jeffrey A. Thompson, Devin C. Koestler   +4 more
doaj   +1 more source

Short Co-occurring Polypeptide Regions Can Predict Global Protein Interaction Maps

Scientific Reports, 2012
A goal of the post-genomics era has been to elucidate a detailed global map of protein-protein interactions (PPIs) within a cell. Here, we show that the presence of co-occurring short polypeptide sequences between interacting protein partners appears to ...
Sylvain Pitre, M. Hooshyar, Andrew Schoenrock, Bahram Samanfar, M. Jessulat, J. Green, F. Dehne, A. Golshani   +7 more
semanticscholar   +1 more source

A Rice Kinase-Protein Interaction Map     [PDF]

Plant Physiology, 2008
AbstractPlants uniquely contain large numbers of protein kinases, and for the vast majority of the 1,429 kinases predicted in the rice (Oryza sativa) genome, little is known of their functions. Genetic approaches often fail to produce observable phenotypes; thus, new strategies are needed to delineate kinase function.
Ding, Xiaodong, Richter, Todd, Chen, Mei, Fujii, Hiroaki, Seo, Young Su, Xie, Mingtang, Zheng, Xianwu, Kanrar, Siddhartha, Stevenson, Rebecca A, Dardick, Christopher, Li, Ying, Jiang, Hao, Zhang, Yan, Yu, Fahong, Bartley, Laura E, Chern, Mawsheng, Bart, Rebecca, Chen, Xiuhua, Zhu, Lihuang, Farmerie, William G, Gribskov, Michael, Zhu, Jian-Kang, Fromm, Michael E, Ronald, Pamela C, Song, Wen-Yuan   +24 more
openaire   +3 more sources

MAP-ping Unconventional Protein-DNA Interactions [PDF]

Cell, 2009
Control of gene expression depends on a myriad of protein-DNA interactions, and the number of proteins involved just got larger. In this issue, Hu et al. (2009) identify hundreds of human proteins that bind to DNA, including many surprises such as the protein kinase ERK2 (MAPK1) that now appears to control gene expression directly.
Dioum, Elhadji M., Wauson, Eric M., Cobb, Melanie H.   +2 more
openaire   +2 more sources

Flexible web-based integration of distributed large-scale human protein interaction maps

Journal of Integrative Bioinformatics, 2007
Protein-protein interactions constitute the backbone of many molecular processes. This has motivated the recent construction of several large-scale human protein-protein interaction maps [1-10].
Chaurasia Gautam, Iqbal Yasir, Hänig Christian, Herzel Hanspeter, Wanker Erich E., Futschik Matthias E.   +5 more
doaj   +1 more source