Nodes with high centrality in protein interaction networks are responsible for driving signaling pathways in diabetic nephropathy [PDF]
PeerJ, 2015 In spite of huge efforts, chronic diseases remain an unresolved problem in medicine. Systems biology could assist to develop more efficient therapies through providing quantitative holistic sights to these complex disorders.
Maryam Abedi, Yousof Gheisari
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Structure and dynamics of the E. coli chemotaxis core signaling complex by cryo-electron tomography and molecular simulations [PDF]
, 2020 To enable the processing of chemical gradients, chemotactic bacteria possess large arrays of transmembrane chemoreceptors, the histidine kinase CheA, and the adaptor protein CheW, organized as coupled core-signaling units (CSU). Despite decades of study,
Cassidy, Keith +8 more
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From ORFeomes to protein interaction maps in viruses.
Genome Research, 2004 Although cloned viral ORFeomes are particularly well suited for genome-wide interaction mapping due to the limited size of viral genomes, only a few such studies have been published.
P. Uetz +3 more
semanticscholar +1 more source
Mapping protein–protein interactions by mass spectrometry
Mass Spectrometry ReviewsAbstractProtein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu +4 more
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Unraveling molecular similarities between colorectal polyps and colorectal cancer: a systems biology approach [PDF]
Intestinal ResearchBackground/Aims Colorectal cancer (CRC) and colorectal polyps are intimately linked, with polyps acting as precursors to CRC. Understanding the molecular mechanisms governing their development is crucial for advancing diagnosis and treatment. Employing a
Mehran Radak, Hossein Fallahi
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Multiple QTL-effects of wheat Gpc-B1 locus on grain protein and micronutrient concentrations [PDF]
, 2007 Micronutrient malnutrition afflicts over three billion peopleworldwide and the numbers are continuously increasing. Developing genetically micronutrientenriched cereals, which are the predominant source of human dietary, is essential to alleviate ...
Asher CJ +22 more
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Folding Lennard-Jones proteins by a contact potential
, 1999 We studied the possibility to approximate a Lennard Jones interaction by a pairwise contact potential. First we used a Lennard-Jones potential to design off-lattice, protein-like heteropolymer sequences, whose lowest energy (native) conformations were ...
Clementi, Cecilia +3 more
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Dynamic Influence Networks for Rule-based Models [PDF]
, 2017 We introduce the Dynamic Influence Network (DIN), a novel visual analytics technique for representing and analyzing rule-based models of protein-protein interaction networks.
Boutillier, Pierre +6 more
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Comparative mapping of host–pathogen protein–protein interactions [PDF]
Current Opinion in Microbiology, 2015 Pathogens usurp a variety of host pathways via protein-protein interactions to ensure efficient pathogen replication. Despite the existence of an impressive toolkit of systematic and unbiased approaches, we still lack a comprehensive list of these PPIs and an understanding of their functional implications.
Shah, Priya S +3 more
openaire +4 more sources
Plant Direct, 2022 The endoplasmic reticulum (ER) houses sensors that respond to environmental stress and underly plants' adaptative responses. These sensors transduce signals that lead to changes in nuclear gene expression.
Venura Herath +5 more
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