Results 51 to 60 of about 6,367,317 (393)

The novel MAPT mutation K298E:mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons [PDF]

, 2013
Frontotemporal lobar degeneration (FTLD) consists of a group of neurodegenerative diseases characterized by behavioural and executive impairment, language disorders and motor dysfunction.
Calo, Laura, Goedert, Michel, Holton, Janice L., Iovino, Mariangela, Lashley, Tammaryn, Lund University., Lund University., Lund University., Muqit, Miratul M. K., Parmar, Malin,, Pfisterer, Ulrich,, Revesz, Tamas, Spillantini, Maria Grazia, Swingler, Robert J., Treacy, Rebecca   +14 more
core   +4 more sources

Deep Proteomics of Mouse Skeletal Muscle Enables Quantitation of Protein Isoforms, Metabolic Pathways, and Transcription Factors*

Molecular & Cellular Proteomics, 2015
Skeletal muscle constitutes 40% of individual body mass and plays vital roles in locomotion and whole-body metabolism. Proteomics of skeletal muscle is challenging because of highly abundant contractile proteins that interfere with detection of ...
A. Deshmukh, M. Murgia, Nagarjuna Nagaraj, J. T. Treebak, J. Cox, M. Mann   +5 more
semanticscholar   +1 more source

Protein Binding to mRNA 3′ Isoforms

Current Protocols in Molecular Biology, 2019
AbstractHere we describe CLIP‐READS, a technique that combines elements of crosslinking and immunoprecipitation (CLIP) and 3′ region extraction and deep sequencing (READS), to provide a genome‐wide map of mRNA 3′ isoform binding by a given messenger ribonucleoprotein (mRNP). In CLIP‐READS, cells are grown to logarithmic phase and are irradiated with UV
Joseph V, Geisberg, Zarmik, Moqtaderi
openaire   +3 more sources

Identification and classification of innexin gene transcripts in the central nervous system of the terrestrial slug Limax valentianus.

PLoS ONE, 2021
Intercellular gap junction channels and single-membrane channels have been reported to regulate electrical synapse and the brain function. Innexin is known as a gap junction-related protein in invertebrates and is involved in the formation of ...
Hisayo Sadamoto, Hironobu Takahashi, Suguru Kobayashi, Hirooki Kondoh, Hiroshi Tokumaru   +4 more
doaj   +1 more source

The Difference in Structural States between Canonical Proteins and Their Isoforms Established by Proteome-Wide Bioinformatics Analysis

Biomolecules, 2022
Alternative splicing is an important means of generating the protein diversity necessary for cellular functions. Hence, there is a growing interest in assessing the structural and functional impact of alternative protein isoforms. Typically, experimental
Zarifa Osmanli, Theo Falgarone, Turkan Samadova, Gudrun Aldrian, Jeremy Leclercq, Ilham Shahmuradov, Andrey V. Kajava   +6 more
doaj   +1 more source

Phosphorylation of MCPH1 isoforms during mitosis followed by isoform‐specific degradation by APC/C‐CDH1 [PDF]

, 2019
Microcephalin‐1 (MCPH1) exists as 2 isoforms that regulate cyclin‐dependent kinase‐1 activation and chromosome condensation during mitosis, with MCPH1 mutations causing primary microcephaly.
Blain, Peter G., Dunn, Michael, Jowsey, Paul, Meyer, Stephanie K., Porter, Andrew, Vidier, Daniel S.   +5 more
core   +2 more sources

Novel transcripts reveal a complex structure of the human TRKA gene and imply the presence of multiple protein isoforms

BMC Neuroscience, 2015
Tropomyosin-related kinase A (TRKA) is a nerve growth factor (NGF) receptor that belongs to the tyrosine kinase receptor family. It is critical for the correct development of many types of neurons including pain-mediating sensory neurons and also ...
Kristi Luberg, Rahel Park, Elina Aleksejeva, T. Timmusk   +3 more
semanticscholar   +1 more source

The Genetic Regulation of Alternative Splicing in Populus deltoides

Frontiers in Plant Science, 2020
Alternative splicing (AS) is a mechanism of regulation of the proteome via enabling the production of multiple mRNAs from a single gene. To date, the dynamics of AS and its effects on the protein sequences of individuals in a large and genetically ...
Jerald D. Noble, Kelly M. Balmant, Christopher Dervinis, Gustavo de los Campos, Gustavo de los Campos, Márcio F. R. Resende, Márcio F. R. Resende, Matias Kirst, Matias Kirst, Matias Kirst, William Brad Barbazuk, William Brad Barbazuk, William Brad Barbazuk, William Brad Barbazuk   +13 more
doaj   +1 more source

Adenovirus type 5 E4 Orf3 protein targets promyelocytic leukaemia (PML) protein nuclear domains for disruption via a sequence in PML isoform II that is predicted as a protein interaction site by bioinformatic analysis [PDF]

, 2009
Human adenovirus type 5 infection causes the disruption of structures in the cell nucleus termed promyelocytic leukaemia (PML) protein nuclear domains or ND10, which contain the PML protein as a critical component. This disruption is achieved through the
Araujo, Beech, Bernardi, Bernardi, Borden, Bourhis, Callaghan, Carvalho, Condemine, Condemine, Dalessio, Doucas, E. Emmott, Evans, Everett, Everett, Everett, Fagioli, Fagioli, Hoppe, Ishov, Janderova-Rossmeislova, Jensen, K. N. Leppard, Kalderon, Kelly, Liu, M. S. Cortese, Mohan, Nevels, Peng, Romero, Salomoni, Scaglioni, Shen, Sternsdorf, Stracker, T. Rich   +37 more
core   +1 more source

Isoforms of contractile proteins

Progress in Biophysics and Molecular Biology, 1987
Although the mechanism of muscle contraction is essentially the same and the properties ofindividuai contractile proteins such as molecular mass and the overall structure are similar in different types of muscles, more subtle differences were found when muscles of different sources were investigated by using specific and sensitive biochemical ...
openaire   +2 more sources