Results 51 to 60 of about 648,804 (352)

Isoforms of contractile proteins

Progress in Biophysics and Molecular Biology, 1987
Although the mechanism of muscle contraction is essentially the same and the properties ofindividuai contractile proteins such as molecular mass and the overall structure are similar in different types of muscles, more subtle differences were found when muscles of different sources were investigated by using specific and sensitive biochemical ...
openaire   +2 more sources

Protein interaction network of alternatively spliced NudCD1 isoforms

Scientific Reports, 2017
NudCD1, also known as CML66 or OVA66, is a protein initially identified as overexpressed in patients with chronic myelogenous leukemia. The mRNA of NudCD1 is expressed in heart and testis of normal tissues, and is overexpressed in several cancers ...
Patrick Asselin-Mullen, Anaïs Chauvin, Marie-Line Dubois, Romain Drissi, Dominique Lévesque, François-Michel Boisvert   +5 more
doaj   +1 more source

An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels [PDF]

, 2015
Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials.
Beltran-Alvarez, Pedro, Onwuli, Donatus O.   +1 more
core   +1 more source

Protein Binding to mRNA 3′ Isoforms

Current Protocols in Molecular Biology, 2019
AbstractHere we describe CLIP‐READS, a technique that combines elements of crosslinking and immunoprecipitation (CLIP) and 3′ region extraction and deep sequencing (READS), to provide a genome‐wide map of mRNA 3′ isoform binding by a given messenger ribonucleoprotein (mRNP). In CLIP‐READS, cells are grown to logarithmic phase and are irradiated with UV
Joseph V, Geisberg, Zarmik, Moqtaderi
openaire   +3 more sources

Diagnostic utility of prostate health index density prior to MRI-ultrasound fusion targeted biopsy

Exploration of Targeted Anti-tumor Therapy
Aim: Prostate biopsy can be prone to complications and thus should be avoided when unnecessary. Although the combination of magnetic resonance imaging (MRI), the prostate health index (PHI), and PHI density (PHID) has been shown to improve detection of ...
Benjamin H. Press, Soum D. Lokeshwar, Lindsey Webb, Ghazal Khajir, Shayan Smani, Olamide Olawoyin, Mursal Gardezi, Syed N. Rahman, Michael S. Leapman, Preston C. Sprenkle   +9 more
doaj   +1 more source

Splice-Junction-Based Mapping of Alternative Isoforms in the Human Proteome

Cell Reports, 2019
Summary: The protein-level translational status and function of many alternative splicing events remain poorly understood. We use an RNA sequencing (RNA-seq)-guided proteomics method to identify protein alternative splicing isoforms in the human proteome
Edward Lau, Yu Han, Damon R. Williams, Cody T. Thomas, Rajani Shrestha, Joseph C. Wu, Maggie P.Y. Lam   +6 more
doaj   +1 more source

Functional Study of Carboxylesterase 1 Protein Isoforms. [PDF]

Proteomics, 2019
Abstract Carboxylesterase 1 (CES1) is a primary human hepatic hydrolase involved in hydrolytic biotransformation of numerous medications. Considerable interindividual variability in CES1 expression and activity has been consistently reported. Four isoforms of the CES1 protein are produced by alternative splicing (AS).
Wang X, Shi J, Zhu HJ.
europepmc   +4 more sources

Regulation of the Unfolded Protein Response by eIF2Bδ Isoforms [PDF]

Journal of Biological Chemistry, 2010
Cells respond to a variety of stresses, including unfolded proteins in the endoplasmic reticulum (ER), by phosphorylating a subunit of translation initiation factor eIF2, eIF2α. eIF2α phosphorylation inactivates the eIF2B complex. The inactivation of eIF2B not only suppresses the initiation of protein translation but paradoxically up-regulates the ...
Leenus, Martin, Scot R, Kimball, Lawrence B, Gardner   +2 more
openaire   +2 more sources

The Opposite Functions of CD30 Ligand Isoforms

Current Issues in Molecular Biology
TNFSF8/CD30 ligand is a TNF superfamily member expressed on several major immune cell types, including activated monocytes, B, and T cells. The signaling of CD30 ligand through its cognate CD30 receptor has been shown to have effects on cell ...
Ignat Printsev, Elyas Alalli, Janine Bilsborough   +2 more
doaj   +1 more source

Do fragments and glycosylated isoforms of alpha-1-antitrypsin in CSF mirror spinal pathophysiological mechanisms in chronic peripheral neuropathic pain? An exploratory, discovery phase study

BMC Neurology, 2018
Background Post-translational modifications (PTMs) generate a tremendous protein diversity from the ~ 20,000 protein-coding genes of the human genome. In chronic pain conditions, exposure to pathological processes in the central nervous system could lead
Emmanuel Bäckryd, Sofia Edström, Björn Gerdle, Bijar Ghafouri   +3 more
doaj   +1 more source