Results 61 to 70 of about 6,367,317 (393)
Protein interaction network of alternatively spliced NudCD1 isoforms
Scientific Reports, 2017 NudCD1, also known as CML66 or OVA66, is a protein initially identified as overexpressed in patients with chronic myelogenous leukemia. The mRNA of NudCD1 is expressed in heart and testis of normal tissues, and is overexpressed in several cancers ...
Patrick Asselin-Mullen +5 more
doaj +1 more source
Nature Communications, 2014 Prions are lethal infectious agents thought to consist of multi-chain forms (PrPSc) of misfolded cellular prion protein (PrPC). Prion propagation proceeds in two distinct mechanistic phases: an exponential phase 1, which rapidly reaches a fixed level of ...
Malin K. Sandberg +11 more
semanticscholar +1 more source
Genome-wide prediction of disease variant effects with a deep protein language model
Nature Genetics, 2023 Predicting the effects of coding variants is a major challenge. While recent deep-learning models have improved variant effect prediction accuracy, they cannot analyze all coding variants due to dependency on close homologs or software limitations.
N. Brandes +4 more
semanticscholar +1 more source
Diagnostic utility of prostate health index density prior to MRI-ultrasound fusion targeted biopsy
Exploration of Targeted Anti-tumor TherapyAim: Prostate biopsy can be prone to complications and thus should be avoided when unnecessary. Although the combination of magnetic resonance imaging (MRI), the prostate health index (PHI), and PHI density (PHID) has been shown to improve detection of ...
Benjamin H. Press +9 more
doaj +1 more source
BMC Neurology, 2018 Background Post-translational modifications (PTMs) generate a tremendous protein diversity from the ~ 20,000 protein-coding genes of the human genome. In chronic pain conditions, exposure to pathological processes in the central nervous system could lead
Emmanuel Bäckryd +3 more
doaj +1 more source
Calsequestrins in skeletal and cardiac muscle from adult Danio rerio [PDF]
, 2015 Calsequestrin (Casq) is a high capacity, low affinity Ca2+-binding protein, critical for Ca2+-buffering in cardiac and skeletal muscle sarcoplasmic reticulum. All vertebrates have multiple genes encoding for different Casq isoforms.
Argenton, Francesco +6 more
core +1 more source
The Opposite Functions of CD30 Ligand Isoforms
Current Issues in Molecular BiologyTNFSF8/CD30 ligand is a TNF superfamily member expressed on several major immune cell types, including activated monocytes, B, and T cells. The signaling of CD30 ligand through its cognate CD30 receptor has been shown to have effects on cell ...
Ignat Printsev +2 more
doaj +1 more source
Splice-Junction-Based Mapping of Alternative Isoforms in the Human Proteome
Cell Reports, 2019 Summary: The protein-level translational status and function of many alternative splicing events remain poorly understood. We use an RNA sequencing (RNA-seq)-guided proteomics method to identify protein alternative splicing isoforms in the human proteome
Edward Lau +6 more
doaj +1 more source
RNA: A publication of the RNA Society, 2014 Fragile X mental retardation protein (FMRP) is known to exist as several isoforms generated by alternative splicing. This paper shows that two specific isoforms bind the coding region of FMRP mRNA, which contains two G-quadruplexes with higher affinity ...
A. Blice-Baum, M. Mihailescu
semanticscholar +1 more source
Dermatology Reports, 2010 14-3-3 is a highly conserved protein involved in a number of cellular processes including cell signalling, cell cycle regulation and gene transcription. Seven isoforms of the protein have been identified; β, γ, ε, ζ, η, σ and τ. The expression profile of
Line Raaby +4 more
doaj +1 more source